Transthyretin Cardiac Amyloid: 'Dr RR Baliga's "Got Knowledge Doc" Podcasts
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Release Date: 02/07/2024
🧠❤️ Predict. Prevent. Protect: AI’s Lifesaving Role in HCM
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 AI vs Sudden Cardiac Death in HCM 🫀🤖 Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. 📊 MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) 🧠 Integrated data: LGE-CMR 🧲, EHR 📋, and echo/CMR reports 💻 ⚖️ Demonstrated fairness across age and sex subgroups 🔍 Transparent predictions via Shapley values and attention heatmaps A leap toward...
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💡 Personalized, Precise, Powerful: The Rise of Cancer Vaccines 🧪
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
“Vax to the Future: Cancer Immunity Revolution 🧬💉” Cancer vaccines are no longer a promise — they’re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. 📈 Real data from trials in melanoma, ccRCC, and pancreatic cancer ⚔️ PD-1 inhibitors meet targeted T cells 🌍 A safer, scalable future for cancer care 🎧 Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI — “Vaccines in Cancer Treatment...
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🍬 Endothelium Under Attack: The Sweetener-Inflammation Link
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Findings on Aspartame & Heart Health! 🍬🫀 A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. 🧪 Key insights from mice and monkeys: – Aspartame spikes insulin via vagus nerve stimulation – Elevated insulin boosts CX3CL1 expression in endothelial cells – CX3CL1 recruits inflammatory monocytes ➡️ plaque growth & instability 🧬 Blocking CX3CR1 in monocytes stopped plaque progression entirely....
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Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354–430 CE)
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Saint Augustine of Hippo (354–430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.
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Beats, Bytes, Brilliance 🫀💾🌟: The Rise of AI in Echocardiography
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 Just out in JAMA! 💡 PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation — from LVEF to valvular disease — with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. 🌍 Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. 🫀🤖 A major leap toward AI-assisted cardiovascular diagnostics. 🔗 #AIinMedicine #Cardiology #EchoRevolution #PanEcho #DigitalHealth #JAMA #MachineLearning #CardioAI...
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🔌 Power Heist in the Tumor: Neurons Fuel Cancer Spread
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New insights from cancer neuroscience! 🧠🧬 A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes — supercharging their metabolism, stemness, and metastatic potential 🌪️💥 Using a clever tool called MitoTRACER, researchers traced this “mitochondrial hijack” across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases — especially in the brain 🧳🧠 🧪 Targeting this nerve–tumor energy axis may open new doors to stop...
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🧠💡 Memory Matters: A Cardiologist’s Guide to Cognitive Care
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠💓 Cognitive decline and cardiovascular disease often go hand in hand — but they don’t have to spiral together. In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-based care — it’s time to connect the mind and the heart. 📊 Evidence-based strategies 🩺 Practical tools for clinicians 💡 Insights from JACC’s state-of-the-art review 👉 Let’s build heart-smart,...
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Adjuvants & Alzheimer’s: A Shot at Prevention 💥🧬🧠
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠💉 Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementia—possibly by stimulating immune pathways like IFN-γ and TLR4, not just by preventing infection. 📊 In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-month dementia risk than flu-vaccinated peers. 🔬 The common thread? The AS01 adjuvant. 🛡️ Could this be a new frontier in neuroprotection? Let’s discuss. #Vaccines #Dementia #RSV #AS01 #Neuroimmunology...
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💉 Pump, 📉 Pressure, ⚡ Power: Inside the STEMI Shock Solution
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
New Insights from the DanGer Shock Trial! 🫀💡 Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressures—all while using less pharmacologic support. 📉💊 🧪 Native CO improved steadily over 48 hours, hinting at myocardial recovery. 📊 PAC data gives us a front-row seat to the physiology behind the survival curves. 🔬 The editorial dives deeper: timing, technique, and future questions....
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🌐 ACHIEVE-1 Decoded: Efficacy & Safety of Orforglipron in Type 2 Diabetes
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Breakthrough in Type 2 Diabetes Care! 💊🧬 The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weight—without injections and with minimal restrictions! 🌍📉 👨⚕️ 559 patients across 5 countries ⏱️ 40 weeks, 3 dosing arms (3, 12, 36 mg) 📊 HbA1c ↓ by up to 1.48%, weight ↓ up to 7.6% ✅ No severe hypoglycemia 📌 Mild GI side effects during dose titration This is a potential gamechanger for early T2DM care—simple, effective, and...
info_outline🎧 Transthyretin (TTR) Amyloid: Dr RR Baliga "Got Knowledge Doc" PodKast for Physicians
1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935
2. Treatment of Cardiac Transthyretin Amyloidosis: Emdin M, Aimo A, Rapezzi C, et al. An Update. Eur Heart J 2019;40:3699-3706.
3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC
Transthyretin (TTR) Amyloid: "Hot-off-the-Press Dr RR Baliga MUST KNOW FACTS PodKast"
1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935
2. Treatment of Cardiac Transthyretin Amyloidosis: An Update. Eur Heart J 2019;40:3699-3706.
3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC