Is Colchicine Useful in COVID-19?--GRECCO-19 Randomized Trial
Dr. Baliga's 'Podkasts for Curious Docs'
Release Date: 06/24/2020
SOFA-2 ICU Unveiled 🧠⚙️📊 3 Million Patients, 9 Nations, One New Standard
Dr. Baliga's 'Podkasts for Curious Docs'
🚨 SOFA-2 arrives — a thoughtful evolution in critical care scoring 🧠🫁🫀 After nearly 30 years, the SOFA score has been modernized using data from >3.3 million ICU patients across 9 countries. The updated SOFA-2 incorporates contemporary respiratory and cardiovascular supports (HFNC, NIPPV, vasopressors, ECMO) and refines thresholds while preserving simplicity and bedside usability. A meaningful step forward in describing organ dysfunction — with room for future biologically grounded refinement. 📖 Published in JAMA
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SOFA-2 Unveiled 🧠⚙️🌍-📊🩺🚨 — Critical Care Enters a New Era
Dr. Baliga's 'Podkasts for Curious Docs'
SOFA-2 is here — a major advance in assessing organ dysfunction in critical illness 🧠🫁❤️ Three decades after the original SOFA score, this updated framework reflects modern ICU practice — integrating contemporary organ support (ventilation, vasopressors, RRT), delirium recognition, and global feasibility across resource settings 🌍📊 Validated in 3.3M+ ICU patients across 9 countries — a remarkable effort in global critical care science 🏥📈 A powerful step forward in our shared language of severity and recovery. 🔗 JAMA Network Open, 2025
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💔 Peripartum Cardiomyopathy: Detect Early • Treat Aggressively • Protect Mothers
Dr. Baliga's 'Podkasts for Curious Docs'
💔 Peripartum Cardiomyopathy: When a Mother’s Heart Fights for Two Peripartum cardiomyopathy is a leading yet often missed cause of maternal morbidity and mortality—striking late in pregnancy or months postpartum. Early suspicion, timely echo, and guideline-directed therapy save lives. 🩺 🧠 Bromocriptine, careful anticoagulation, and multidisciplinary care are reshaping outcomes, but global disparities persist. 🌍 Let’s amplify awareness, strengthen systems, and protect mothers everywhere. 🤝❤️ #HeartFailure #MaternalHealth #Cardiology...
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Rethinking “default arterial lines” in the ICU 🧠🚑
Dr. Baliga's 'Podkasts for Curious Docs'
Rethinking “default lines” in the ICU 🧠🚑 A landmark NEJM trial shows that in patients with shock, deferring arterial catheterization and using automated cuff monitoring was noninferior for 28-day mortality — and reduced catheter-related complications. A gentle reminder: not every sick patient needs a needle to be well cared for. Precision isn’t only invasive — sometimes it’s thoughtful, measured, humane. 🌿💡 #CriticalCare #ICU #NEJM #Shock #Hemodynamics #PatientSafety
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Light Pollution, Circadian Disruption, Cardiac Vulnerability 🌃🕰️🫀
Dr. Baliga's 'Podkasts for Curious Docs'
🌙 Bright Nights, Higher Heart Risk ❤️🩹 New findings in JAMA Network Open highlight that greater exposure to artificial light at night is associated with significantly increased risks of coronary artery disease, myocardial infarction, heart failure, atrial fibrillation, and stroke — independent of sleep duration, lifestyle factors, and genetics. 💡 Clinical takeaway: Protecting circadian rhythms is cardiovascular prevention. Darker nights = healthier hearts. 🛌 Simple steps: blackout curtains, limit screens before bed, use warm/dim evening lighting....
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Rethinking Immune Aging: It Starts Sooner Than We Think 💡🩸
Dr. Baliga's 'Podkasts for Curious Docs'
The immune clock starts earlier than we think ⏳🧬 A landmark Nature study shows that immune aging begins quietly in midlife — decades before clinical frailty. Using >16M single-cell profiles and longitudinal vaccine responses, researchers found: • Stable, early transcriptional drift in naïve & memory T cells • A subtle TH2 shift that may weaken antiviral antibody quality • Reduced IgG class-switching to repeat flu antigens (e.g., B/Phuket) • No acceleration from CMV infection despite compositional shifts The message? Immune aging is gradual, not...
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Seven Years Later: TAVR Didn’t Blink 😎🫀
Dr. Baliga's 'Podkasts for Curious Docs'
🫀 TAVR or SAVR? The 7-Year Truth New 7-year results from the PARTNER-3 trial (NEJM) show that in low-risk patients with severe symptomatic aortic stenosis, TAVR holds pace with surgery — delivering comparable survival, stroke rates, rehospitalization, valve durability, and quality-of-life outcomes. 🔎 Highlights • Composite events: 34.6% (TAVR) vs 37.2% (SAVR) • Mortality: 19.5% vs 16.8% • Valve failure: 6.9% vs 7.3% • Aortic gradients remain low in both groups 💡 Clinical rhythm: less AF with TAVR; more pacemakers and paravalvular leak. This study...
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Dr RR Baliga's Philosophical Discourses: Baruch Spinoza (Netherlands, 1632–1677 CE) – Ethics
Dr. Baliga's 'Podkasts for Curious Docs'
🌿 Spinoza: Reason, Nature, Freedom Today’s deck explores Baruch Spinoza — the quietly revolutionary Dutch philosopher who shaped rationalism, modern biblical criticism, and secular democracy. He saw God = Nature, championed intellectual freedom, and argued that understanding our emotions transforms them — not far from cognitive-behavioral ideas we use in modern medicine. His reminder feels timely: human flourishing grows where inquiry is free, passions are understood, and systems support dignity + reason. 🧠🔍💬 Clarity is liberation.
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New Mitral Frontier 🚪🫀🚶♂️ TMVR Opens a Third Pathway
Dr. Baliga's 'Podkasts for Curious Docs'
A new era for complex mitral regurgitation. The ENCIRCLE pivotal trial in The Lancet reports that fully percutaneous, transfemoral, transseptal TMVR (SAPIEN M3) achieved durable MR reduction (≈96% ≤1+ at 1 year), low early mortality, and meaningful improvement in symptoms and quality of life for patients unsuitable for surgery or TEER. A third pathway for mitral disease is emerging—one built on precision access, valve-in-valve durability planning, and advancing patient selection. Innovation meeting clinical need. 🚀🫀📈
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Immune Fountain of Youth? Mesenchymal Magic 💧✨
Dr. Baliga's 'Podkasts for Curious Docs'
🧬 Can we rejuvenate the aging immune system? A remarkable Nature Biotechnology study shows that a rare population of periostin-positive mesenchymal niche cells can rebuild the adult thymus, recruit new T-cell progenitors, and restore immune responses after injury. By harnessing CCL19-expressing stromal support, the authors demonstrate a path toward immune renewal in aging, cancer therapy recovery, and HSCT survivors. ✨ A glimpse of regenerative immunology’s future: Rebuild. Recruit. Rejuvenate. #Immunology #Aging #RegenerativeMedicine #Thymus #TCells...
info_outlineIs Colchicine Useful in COVID-19?--GRECCO-19 Randomized Trial
Dr RR Baliga 'Got Knowledge Doc' Podkasts for Physicians
Colchicine for the Treatment of Myocardial Injury in Patients With Coronavirus Disease 2019 (COVID-19)—An Old Drug With New Life? doi: 10.1001/jamanetworkopen.2020.13556