Byrne NJ, Soni S, Takahara S, et al. Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure. Circ Heart Fail. 2020;13(6):e006573. doi:10.1161/CIRCHEARTFAILURE.119.006573
Fasting for Chemotherapy Induced Heart Failure?
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
Release Date: 03/20/2024
🏆 People, Prices & Policy: The 2026 Economics Nobel Explained
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🏆 What can physicians learn from the 2026 Economics Nobel? Robert E. Hall and Michael Woodford transformed macroeconomics by looking beneath the headline numbers—to the decisions and expectations of households and businesses. 🧠 The lesson feels remarkably clinical: diagnose before you treat. A downturn caused by weak demand is not the same as one caused by a supply shock—and may require a different response. 💡 Same symptom ≠ same solution. Perhaps economics and medicine share more than we think.
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💪 Protein, Portions & Perspective: How Much Is Enough for South Asians?
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🥗 Protein in India: Myths, Meals & Muscle Are claims of widespread protein deficiency overlooking calories and food quality? Anura Kurpad and Harshpal Singh Sachdev’s newspaper article examines this debate. 💪 Its calorie-based estimates translate to ~45 g/day for active adults and up to 60 g/day for older inactive adults at 2,000 kcal/day—examples, not universal targets. 🍛 The takeaway: adequate energy, varied foods and individual assessment. 🎙️ Dr RR Baliga’s Podkast for the Kurious Doc. Where Curiosity Meets Clarity! #Protein #Nutrition #HealthyAging
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⚖️ GZMK vs GZMB: The T-Cell Balance That May Define Healthy Aging
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🧬 Can your T cells reveal how well you’re aging? A remarkable Immunity study integrated 2,609 people and >12 million cells across 8 cohorts. Researchers identified divergent CD8+ effector-memory T-cell trajectories: a higher GZMK+/GZMB+ ratio tracked healthier aging, while GZMB+ cells were linked to inflammation, poorer health and mortality. Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories.pdf 💡 The intriguing possibility: biological aging may be captured not simply by how many years...
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62.5% 5-year all-cause mortality in symptomatic Peripheral Arterial Disease
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🦵 PAD is not simply a disease of the legs—it is systemic atherosclerosis with profound cardiovascular and human consequences. 📊 Symptomatic PAD: 62.5% 5-year all-cause mortality. 🌍 >316 million adults affected globally. 🚶 Yet mobility, pain, independence and mental health are too often overshadowed by patency and amputation. 💡 The Lancet’s message is simple: count what matters to patients. 🫀 Recognize PAD. Treat systemic risk. Preserve lives—and livelihoods. #PAD #Atherosclerosis #Cardiology #VascularMedicine
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🔍 Great Doctors Series: Vesalius—The Doctor Who Dared to Look
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🫀 What happens when a young doctor stops trusting the textbook—and looks for himself? Meet Andreas Vesalius (1514–1564), whose human dissections exposed errors inherited from Galen’s animal anatomy. 🔍 At just 28, he published the magnificent De Humani Corporis Fabrica (1543), helping transform anatomy into a science grounded in direct observation. 📖 His enduring lesson for medicine: respect authority—but verify with evidence. 🔬 🎙️ Another episode of my Great Doctors Series—Where Curiosity Meets Clarity!
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🧠 Menopause, Molecules & Memory: Is the Brain Sending a Warning?
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🧠 Menopause, Molecules & Memory Could menopause be a “stress test” for the brain? 🔬 Researchers identified 16 brain-related blood proteins elevated after menopause. The signature tracked with higher FSH and lower estradiol, while inflammatory cytokines were especially elevated in women reporting night sweats. 🩸 Intriguingly, several of the same proteins were elevated in older women with cognitive decline or dementia. 💡 Menopause may offer a critical midlife window to identify brain vulnerability—and perhaps intervene early. ⚠️ Promising, but preliminary: larger...
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🐾 Why Big Dogs Age Faster: An Epigenetic Answer
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🐕 Bigger Dogs, Faster Clocks, Shorter Lives? A fascinating Science study analyzed 1,640 DNA methylomes from 894 dogs. 🧬 Epigenetic age predicted mortality, with each additional year of residual biological age associated with a 15% higher mortality hazard. Most strikingly, larger dogs showed 31% stronger age-related transposable-element demethylation, especially involving evolutionarily young LINE1 elements. 💡 Large dogs may not simply die earlier—their molecular aging appears compressed and accelerated. A powerful natural model for understanding longevity, genomic instability, and...
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2026 Nobel Chemistry Prize: ⚗️ Tiny Tilt, Giant Shift: How Chemistry Chooses a Side
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🏆🧬 Tiny Tilt, Giant Shift: How Chemistry Chooses a Side Why does life favor one molecular “hand”? The 2026 Chemistry Nobel honors Henri Kagan and Kenso Soai for showing how tiny chiral imbalances can become dramatically amplified. ⚗️ In Soai’s landmark experiment, just 2% enantiomeric excess became 87%—and later autocatalytic reactions reached 99.99%. 💊 Why physicians should care: stereochemistry can determine whether a drug works at all—think L-DOPA. A tiny molecular bias can become biological destiny. 🔬✨
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🛡️ Beyond Cholesterol: GIMAP6, Vascular Defense & Atherosclerosis
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🧬 Can atherosclerosis become lethal even without high cholesterol? A fascinating Cell study identifies GIMAP6 as an immune–vascular safeguard. Loss of GIMAP6 disrupts endothelial integrity and activates a mitoROS → PPARγ → CD36 pathway, driving macrophage lipid uptake, foam cells, inflammation, atherosclerosis, MI and heart failure—even without hyperlipidemia. ❤️ Human hypomorphic GIMAP6 variants also tracked with premature cardiovascular disease. 💡 Take-home: LDL matters enormously—but susceptibility within the vessel wall matters too.
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Beyond Breast Cancer 🩻❤️: When a Mammogram Warns the Heart
Dr. RR Baliga's 'Podkast for the Kurious Doc'. Where Curiosity meets Clarity!
🩻 Could a mammogram also offer a window into cardiovascular risk? ❤️ Breast arterial calcification (BAC), once largely dismissed as incidental, is increasingly recognized as a cardiovascular risk signal. Greater BAC burden has been associated with adverse outcomes, including stroke and heart failure. Maryland now requires BAC notification on routine mammograms. 💡 The practical message: see BAC → think cardiovascular risk assessment. ⚠️ But BAC ≠ coronary artery calcium, and we still lack randomized evidence that BAC-directed intervention improves outcomes. Perhaps the...
info_outlineFasting for Chemotherapy Induced Heart Failure?
Dr RR Baliga's 'Got Knowledge Doc' PodKasts for Physicians
de Groot S, Lugtenberg RT, Cohen D, et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nat Commun. 2020;11(1):3083. Published 2020 Jun 23. doi:10.1038/s41467-020-16138-3
Not Medical Advice or Opinion