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#6 - Molecular Root Cause for Insulin Resistance

The Meta Health Podcast

Release Date: 09/29/2021

#23 - Holistic Hypocrisy and Supplement Scams show art #23 - Holistic Hypocrisy and Supplement Scams

The Meta Health Podcast

Call it holistic, functional, metabolic, integrative, longevity, or whatever, but this episode expresses some of my concerns about the direction of what I refer to as the rising "alt health" movement. Interestingly, I'm part of both alt health and mainstream medicine, so I'll share my take from both sides. I'll discuss: The story of "Dr.Bob," a fictional alt health practitioner whose practice is rife with hypocrisy and questionable practices The story of "Diane," a fictional patient anecdote based on patient and audience feedback, who is going bankrupt purchasing alt health services. ...

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#22 - Lipids Part 2: Cholesterol Numbers and Heart Disease Risk show art #22 - Lipids Part 2: Cholesterol Numbers and Heart Disease Risk

The Meta Health Podcast

In this episode we will tie together cholesterol metabolism using the boat vehicular model from Part 1, and understanding your own cholesterol results in greater depth. My free cholesterol e-book summarizes key numbers and concepts discussed in this episode. We'll discuss the following:  Review of lipid boats and cholesterol metabolism Understanding the impact of lifestyle on blood vessel health Key characteristics of lipid particles driving heart disease Overlooked cholesterol numbers that matter most  Hidden heart disease risks you need to prioritize

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# 21 - Lipids Part 1: Metabolic Trafficking using Cars and Boats show art # 21 - Lipids Part 1: Metabolic Trafficking using Cars and Boats

The Meta Health Podcast

Lipid (cholesterol) physiology is complicated, but essential for you to understand as part of metabolism, health, and longevity. Let's simplify lipids (and glucose) using cars, boats, and traffic. This sets the foundation for future episodes where I discuss the practical implications of lipids and heart disease risk. We'll discuss the following: The vehicular metabolic traffic model Quick review of glucose and insulin metabolism Introducing lipoprotein boats  Understanding glucose cars and lipid boats together What we mean by "fat-burner" and "sugar-burner" 

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#20 - Glucose Variability: An Essential Metabolic Metric show art #20 - Glucose Variability: An Essential Metabolic Metric

The Meta Health Podcast

Glucose variability (GV) is an important metric that expands upon the current limited application of fasting blood glucose and hemoglobin A1C. In this episode we'll discuss: The limitations of A1C and fasting blood glucose What is GV and why it matters? How GV is related to inflammation and chronic disease Glucose dipping and its connection to weight gain Defining an optimal range for GV  

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#19 - Rethinking Hemoglobin A1C and Are You Truly Prediabetic? show art #19 - Rethinking Hemoglobin A1C and Are You Truly Prediabetic?

The Meta Health Podcast

The hemoglobin A1C is a useful, yet imperfect glycemic marker which we'll explore further in this episode where we discuss: The origins of the glycohemoglobin test (aka A1C) The flaws of A1C testing and why you may not be prediabetic Insulin resistant markers that should accompany A1C testing The impact of ethnicity on A1C testing An exciting new metric that may be superior to the A1C test

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#18 - Multiethnic Metabolism and Heart Disease Risk show art #18 - Multiethnic Metabolism and Heart Disease Risk

The Meta Health Podcast

There are significant ethnicity-specific differences in metabolism and heart disease risk that are not often discussed. In this episode we cover: A brief overview of insulin resistance (IR) and the renin angiotensin system (aka RAS) How IR and RAS present in major ethnic groups like African Americans, Asians (including South Asians), Hispanics, etc. My simplistic model for categorizing IR to better explain ethnic risk Ethnic-specific lifestyle changes to improve metabolism and reduce heart disease risk

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#17 - Blood Pressure, Body Fat, and Sodium show art #17 - Blood Pressure, Body Fat, and Sodium

The Meta Health Podcast

I'm going to explain the interaction between blood pressure, body fat, and sodium by explaining the all important RAAS (renin-angiotensin-aldosterone system). Understanding this system can help you optimize blood pressure, heart, and overall vascular health. We'll discuss the following: Understanding how RAAS works How body fat interacts with RAAS Why sodium is not the root cause of high blood pressure The connection between insulin resistance and RAAS Lifestyle measures to effectively reduce blood pressure 

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#16 - Getting Your Body to Burn Fat show art #16 - Getting Your Body to Burn Fat

The Meta Health Podcast

Understanding the mechanism behind how your body stores and burns fat (aka lipolysis) will help you incorporate lifestyle strategies to help you lose excess body fat.  In this episode we discuss: The science of burning body fat  Different types of body fat based on color and location Teaching your body to burn excess fat through thermogenesis Multiple lifestyle strategies to enhance fat loss

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#15 - Science of Muscle Growth and Optimal Protein Intake show art #15 - Science of Muscle Growth and Optimal Protein Intake

The Meta Health Podcast

Muscles are a key organ for longevity, yet the majority of patients I see in my clinic suffer metabolically, physically, and even mentally from a lack of optimal muscle strength. In this episode I discuss:

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#14 - Why Everyone Should Experience Ketosis Regardless of their Diet show art #14 - Why Everyone Should Experience Ketosis Regardless of their Diet

The Meta Health Podcast

Ketogenic diets are commonly associated with meat-based diets, but this misconception isolates individuals from accessing this precious metabolic state. In this episode I discuss the following:

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More Episodes

We laid the groundwork for understanding the root cause of insulin resistance in prior episodes, and now we have reached a major climax in this saga where we discuss one of the molecular root causes for this condition.  There will be some James Bond references and an explanation of insulin resistance using a kitchen power outage as an example.  We’ll end this episode by panning out from the molecules to the meta picture of insulin by going over 3 key substances that trigger insulin resistance and how these are linked to lifestyle.