Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Release Date: 05/30/2022
Chad Andresen on Lunosa’s Injectable Neurostimulator and Lessons from Stimwave
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode, we sit down with , Chief Business Officer of , to explore a groundbreaking approach to treating obstructive sleep apnea. Lunosa is developing a self-expanding, injectable neurostimulator that aims to replace invasive facial surgeries with a minimally invasive, high-impact solution — tapping into a $10 billion market. Chad also reflects on his time at , a pioneering neuromodulation company that saw both innovation and controversy. He shares insights from testifying against Stimwave’s former CEO, lessons learned from the company’s collapse, and how those experiences shape...
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Frederik Ceyssens and the ReVision Implant Team: Building a Visual Cortical Prosthesis to Restore Sight
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this special on-location episode recorded in Leuven, Belgium, we sit down with the co-founders and technical leaders of — (CEO), (CTO), and (CSO). The team shares their journey developing a high-density, intracortical visual prosthesis aimed at restoring vision for the blind. From developing reliable insertion technology to achieving long-term biocompatibility in nonhuman primate models, ReVision Implant is at the forefront of neurotech innovation. Tune in to hear about their challenges, breakthroughs, and what’s next in the race to cure blindness through brain stimulation. This...
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Julio Martinez-Clark: Accelerating Clinical Trials Through Latin America with Bioaccess
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode, we speak with , CEO and co-founder of , a contract research organization helping Medtech and Biopharma startups slash months off their clinical timelines. With a focus on Latin America, Bioaccess enables early feasibility and first-in-human trials to be conducted faster, more affordably, and with high-quality data suitable for FDA and EU submissions. Julio shares how their global site network—built over 20 years—helps startups navigate regulatory hurdles, reduce costs, and de-risk innovation, all while improving patient lives in emerging markets. This episode is sponsored...
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Nathan Piland of Nunex: From Medtech Concept to Commercialization
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode of the Neural Implant Podcast, we’re joined by , CEO of , a consulting firm that specializes in helping MedTech companies navigate the complex journey from concept to commercialization. With over two decades of experience across regulatory strategy, product development, and market access, Nathan shares invaluable insights into the critical steps for MedTech startups and established companies looking to succeed in today’s competitive landscape. Tune in as we discuss the unique challenges of the neurotech industry, strategic consulting for MedTech ventures, and how Nunex is...
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Eugene Daneshvar: Navigating Neurotech IP with Fairer Pricing and Entrepreneurial Spirit
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode of the Neural Implant Podcast, we welcome Dr. Eugene Daneshvar, founder of Black Swan Intellectual Property (BSIP), a boutique law firm specializing in intellectual property for neurotech and medtech innovations. With a background in biomedical engineering and law, Eugene has a unique perspective on protecting the cutting-edge ideas that drive the future of healthcare technology. After years of working at a larger firm, Eugene founded BSIP to provide more accessible, fair, and transparent pricing for IP services, moving away from the traditional hourly billing model. In...
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Maurits Ortmanns: Advancements in ASIC Design for Neurotech Implants
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode, we welcome , a leading expert in ASIC design and professor at the , Germany. With a distinguished career in microelectronics, Dr. Ortmanns has contributed extensively to the development of integrated circuits for biomedical applications. He shares insights into the critical role of ASIC (Application-Specific Integrated Circuit) design in advancing neurotech implants, focusing on low-power, high-speed circuits that are essential for optimizing the performance and reliability of these devices. Dr. Ortmanns also discusses the challenges and future of circuit integration in...
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Expanding Horizons in Neuroprosthetics: A Conversation with Andreas Forsland
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode of the Neural Implant Podcast, host Ladan Jiracek engages in an insightful dialogue with , founder and CEO of . The discussion covers Cognixion's pioneering augmented reality headset with EEG sensing, designed to enhance communication for individuals with speech and motor challenges. Andreas describes the journey from creating a speech augmentation device to developing a versatile platform, the Axon-R, which is now being utilized by health systems and researchers for various clinical applications. They explore the platform's form factor, capabilities, and its role in empowering...
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Exploring the Miami Project to Cure Paralysis with David McMillan
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
In this episode of the Neural Implant Podcast, host Ladan speaks with , the Director of Education Outreach for the and a Research Assistant Professor in the Department of Neurological Surgery at the University of Miami. They discuss the Miami Project's work, particularly in spinal cord injury research and neuroprosthetics. Topics include clinical trials, combining therapies, regulatory challenges, and the importance of rehabilitation in conjunction with therapeutic technologies. 00:00 Introduction to the Neural Implant Podcast 00:16 Meet David McMillan: Director of Education...
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Exploring Contract Engineering in Neurotechnology with Javier Schandy and Nicolas Barabino
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
I n this episode of the Neural Implant Podcast, host Ladan welcomes and from , an engineering services company based in Uruguay. They discuss their work in firmware, hardware, and software development for medical devices, emphasizing their specialization in wireless communications and test automation. They also explain the benefits of contract engineering, the challenges they face, and highlight an exciting project involving an injectable neurostimulator. The conversation covers the history of neurotechnology development in Uruguay, the process and dynamics of working with clients, and...
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Stephen Ho: Exploring Neurotech in Cinema with the Neurratives Podcast
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Today's guest is from Blackrock Microsystems. While we've featured Blackrock guests before, Stephen's appearance today is driven by his podcast, , where neurotech-inspired movies are reviewed and discussed. Top 3 Takeaways: "Our goal for the podcast isn't necessarily to be overly technical, requiring a neuroscience degree to understand. We're often deep in the subject matter and may get a bit jargony, but broadly, we aim to be accessible without pretending to be accomplished neuroscience researchers." “Due to the subject's nature, movies dealing with neuroscience themes...
info_outlineDr Josh Siegle is a senior scientist working at the Allen Institute working on large-scale electrophysiology using tools like the Neuropixels probe. He is also heavily involved in the design and distribution of Open Ephys which is an open-source electrophysiology tool.
***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here***
Top three takeaways:
- "The dark matter problem is where the number of cells that we record is almost always less than the number of cells that we actually know to be in the tissue around the electrodes. This could be because there are neurons near the electrodes that just don't fire action potentials, their action potentials look very similar to other nearby neurons, or maybe the listening radius of our electrodes is not quite as large as we would expect it to be."
- "A big advantage of working at the Allen Institute is that we have very generous internal funding from Paul Allen. And so although we do apply for grants when it makes sense, for most people at the Allen Institute, getting grant funding is not an existential threat to their research."
- Open Ephys has recently started offering virtual 1-on-1 training sessions to help people get up and running with their tools. This is aligned with their goal of making open-source tools even more accessible throughout the neuroscience community.
0:45 Ladan introduces the episode and the guest, Dr. Josh Siegle
4:00 "What is the Neuropixels probe and how does it work? Why is it important?"
8:00 What capabilities does working with IMEC bring?
11:15 How exactly were you working with IMEC?
12:30 Sponsorship by Ripple Neuro
13:15 How does the pitch of the Neuropixels probe compare to biology?
16:45 What is the Allen Institute like?
20:15 What kind of mix of people work at the Allen Institute?
21:15 "What's the stated aims of the Institute again?"
22:00 What is the Open Ephys project you had worked on before?
27:45 What is the Open Ephys training like?
29:30 Do companies love or hate Open Ehpys?
31:00 "Is there anything that we didn't talk about that you wanted to mention?"