Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Release Date: 05/30/2022
Giacomo Valle on working with patients, animals, and computational models for neurotech
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is a post-doc researcher at ETH Zurich working in the to find tools for neurologically disabled amputees and diabetic persons. They look at how to decode from devices and what that would look like for the development of new devices. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "We're working on the sensory feedback restoration in people where there is a sensory loss due to neuropathy. The limbs are there there is sensory loss due to the degeneration and neuropathic degeneration. And then with electrical simulation is possible...
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Jotthe Kannappan on being a Venture Capitalist for minimally invasive medical technologies
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is an associate at which is all about converging robotic systems, digital tools, and clinical needs in search of new ways to understand, diagnose, treat and manage disease. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "It's not about rejection. It's about enabling the best possible fit between an entrepreneur and an investor who is able to who's able to really do what the company needs for them" "The typical things that stand out are really well clearly articulated message again about an unmet medical needs is something that...
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Benjamin Stecher on being a Parkinson's patient advocate
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
runs a blog called the where he talks about his battle with Parkinson's disease. He has been implanted with a Deep Brain Stimulator an is also on the patient advisory board of Rune Labs where he gives them a perspective from the patient's point of view. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: "It got to the point where the Livadopa medication on-off fluctuations were so impairing to my daily life that I had maybe like an hour where I felt normal per day" "But to compare it to the medication now, it's night and day....
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Dr Melanie Ecker on conformal soft neural electrodes in the gut-brain axis
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is a professor at the focusing on smart polymers for biomedical applications. She has worked on conformal and biocompatible neural devices to study the electrophysiology of the enteric nervous system. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: The neurons in the gut-brain axis have not been investigated much by neural probes because of the softness of the intestines "The beauty about the intestines is in comparison to the brain, our probes, the electrodes don't need to be that tiny" The key to recruiting lots of good student...
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Dima Gazda and the prosthetic arm that learns with you by Esper Bionics
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Dima Gazda is the CEO and founder of which is a company that makes a prosthetic arm that gains abilities overtime with you. They plan to use this 'simple' neurotech solution to springboard them solve other larger neurotech problems. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: We are building an ecosystem and will be building more products in addition to the robotic arm. Next will be a better user control system and then a robotic leg A physician can only add about 3000 patient-years of life but an engineer and...
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Lindsay Hartland on recruiting and being recruited at the highest levels in neurotech
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
partners with Neuromodulation Device company Owners, Leaders, and Investors across the US & Europe to source the talent they need in order to succeed with Hanison Green Ltd. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: Sometimes it's better to not hire somebody but rather have a part-time position or even have them work for free in exchange for shares or honor "The main challenge any company will find when looking to grow their business is the best people tend to be working in jobs that they quite like....
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Anuj Bhardwaj on the noninvasive ultrasound therapy for treating inflammation and pain from SecondWave Systems
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is the CEO of which is a wearable ultrasound noninvasive therapy especially for suppressing chronic inflammation and pain signals. ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "We're going to use a disposable coupling component that a patient uses to adhere this and couple it to the body for 18 minutes while they remain in a reasonably sedentary condition. They would do that once a day." "The cost of the healthcare system is often between one to $200,000 per year for patients that take biologics like Enbrel. So that's a...
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Giovanni Lauricella how Neurotech Companies should find investments for their startups
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is the cofounder and managing partner at where they find people, money and insight for MedTech startup companies. Giovanni comes on a second time to talk about how to find investment for neurotech startups ***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services Top 3 Takeaways: "If you take bad money it could really ruin a company. Good money simplistically saying is- You find an investor who really knows how to add value to your company beyond simply writing you a check." "An investible story from the eyes of an investor is number one. And number two,...
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Dr. Talya Miron-Shatz on designing better neural devices using psychology and user interfaces
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is an author, researcher, and speaker who is the author of "" which is a book about medical decision making. She talks about the data generated from neuro devices and what patients can do with it. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top 3 Takeaways: There is an opportunity to turn data generated by neuro medical devices into insights that are easy to digest "free, the data, free the data! And I was thinking - to whom? And what are they going to do with it? It's like someone delivering boxes upon boxes of papers to your front door. And...
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Dr Josh Siegle on large-scale electrophysiology and his Open Ephys Platform
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is a senior scientist working at the Allen Institute working on large-scale electrophysiology using tools like the Neuropixels probe. He is also heavily involved in the design and distribution of which is an open-source electrophysiology tool. ***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools Top three takeaways: "The dark matter problem is where the number of cells that we record is almost always less than the number of cells that we actually know to be in the tissue around the electrodes. This could be because there are neurons near the...
info_outlineDr Josh Siegle is a senior scientist working at the Allen Institute working on large-scale electrophysiology using tools like the Neuropixels probe. He is also heavily involved in the design and distribution of Open Ephys which is an open-source electrophysiology tool.
***This podcast is sponsored by Ripple Neuro, check out their Neuroscience Research Tools here***
Top three takeaways:
- "The dark matter problem is where the number of cells that we record is almost always less than the number of cells that we actually know to be in the tissue around the electrodes. This could be because there are neurons near the electrodes that just don't fire action potentials, their action potentials look very similar to other nearby neurons, or maybe the listening radius of our electrodes is not quite as large as we would expect it to be."
- "A big advantage of working at the Allen Institute is that we have very generous internal funding from Paul Allen. And so although we do apply for grants when it makes sense, for most people at the Allen Institute, getting grant funding is not an existential threat to their research."
- Open Ephys has recently started offering virtual 1-on-1 training sessions to help people get up and running with their tools. This is aligned with their goal of making open-source tools even more accessible throughout the neuroscience community.
0:45 Ladan introduces the episode and the guest, Dr. Josh Siegle
4:00 "What is the Neuropixels probe and how does it work? Why is it important?"
8:00 What capabilities does working with IMEC bring?
11:15 How exactly were you working with IMEC?
12:30 Sponsorship by Ripple Neuro
13:15 How does the pitch of the Neuropixels probe compare to biology?
16:45 What is the Allen Institute like?
20:15 What kind of mix of people work at the Allen Institute?
21:15 "What's the stated aims of the Institute again?"
22:00 What is the Open Ephys project you had worked on before?
27:45 What is the Open Ephys training like?
29:30 Do companies love or hate Open Ehpys?
31:00 "Is there anything that we didn't talk about that you wanted to mention?"