Lothar Krinke on adaptive Deep Brain Stimulation at Newronika
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Release Date: 12/10/2022
Steve Goetz: Revolutionizing Mental Health Treatment as CTO of Motif Neurotech
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is now the Chief Technology Officer at which is developing a minimally invasive neural implant for the treatment of depression and mental health issues. Steve was at Medtronic for 26 years before moving over to the startup landscape. Top 3 Takeaways: "Starting a big program that you don't know how to finish is a very expensive endeavor, and so you want to really shake out all the science risk, all the technology risk, be pretty sure you can execute a thing before you turn on that big engine because it's expensive once you go" "We know stimulation of the dorsal lateral...
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Eric Glowacki on cutting edge neural implant fabrication
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is a research group leader at the Central European Institute of Technology () located in Brno, Czech Republic. There he studies neural implant fabrication and materials specializing in silicon, parylene, and polyimide devices. He has also started to designs and fabricate devices on a contract basis for other research groups and companies. And, his institute is the one that has been recently sponsoring the podcast! This podcast is sponsored by CEITEC Nano, check out their Neurotech Device Manufacturing Capabilities Top 3 Takeaways: "You can just buy stuff on the internet very simple red...
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Gene Fridman on his freeform stimulator allowing for more neural stimulation possibilities
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is an Associate Professor in the Department of Otolaryngology Head and Neck Surgery and also has appointments with the Department of Biomedical Engineering and the Department of Electrical and Computer Engineering. His research is in the areas of bioinstrumentation and neural engineering. In this episode we talk about his freeform nerual stimulator which allows for DC and any other waveforms without any electrolytic effects on the electrodes. This opens up many possibilities for neural stimulation. We also talk about his startup Aidar which is like a 'tricorder' all-in-one medical diagnostic...
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Kurt Haggestrom on Synchron's Stentrode and Synch Switch
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
comes on to talk about the latest new from , which has developed the Stentrode as well as the new Synchron Switch. Kurt talks about his new role as Chief Commercial Officer and where the company is heading. ***This podcast is sponsored by CEITEC Nano, check out their Neurotech Device Manufacturing Capabilities *** Top three takeaways: 1. "The beauty of this approach is that the blood vessels are an amazing place. To be able to put implants and we've, we're leveraging really decades of science and medical devices in say, the coronary space and the heart space. We know that these...
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Pawel Soluch on launching the Medtech Coaching program with me
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Pawel Soluch is a returning guest who goes over his work at , then his consulting at , and now finally he talks about the program that he is launching with me! Top 3 Takeaways: Pawel and I (Ladan) are launching the Medtech Coaching program which will be aimed at helping medical device executives gain success in their businesses Coaching is different from consulting in that we do not generate anything for you but instead help you to become the best medtech executive you can possibly be In addition to group coaching we will also be offering individual coaching and also a retreat in January...
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Mounya Elhilali on her auditory processing selectivity research
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
did the keynote talk at the . I was able to sit down with her and talk to learn more about her auditory processing selectivity research. Top 3 Takeaways: Nurses especially can get used to beeping and alarms which can be dangerous for patients. "Under anesthesia, you see some basic responses, but they are different than when you engage the, let's say, an animal in an awake state, and then when they are awake and actually behaving and engaging with the system" Audio recordings can be tuned to remove ambient noise but they need to be perfectly calibrated to distances between microphones. ...
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Suraj Mudichintala on investing in bioelectronic medicine companies with Action Potential Venture
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Suraj Mudichintala is a Senior Associate at Action Potential Capital which is GSK's bioelectronic medicine venture fund. Top 3 Takeaways: "Our fund is different in that we invest actually directly off of GSK's balance sheet. So we're what's called an evergreen fund where we don't actually have a fund size" "The way that I think about it is that a VC is really paid to allocate capital but really is really paid to think. You really have to think about what is the next space or the next technology that could disrupt a space? And because of that, it's a much you often have to take a much more...
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Balint Varkuti on turning neuromodulation technologies into Brain-Computer-Interfaces using software by CereGate
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
Balint Varkuti is the CEO of CereGate which unlocks new capabilities for existing neuromodulation technologies using software. Top 3 Takeaways: "the brain is naturally wired for pattern perception for learning, and that's really what we do. We send signals that the brain very quickly can pick up." "You do not need to exclusively be focused mentally, consciously on interpreting these signals. Rather it becomes second nature. Our favourite analogy is saying it is like braille for the brain." "With hardware, you sometimes have simply the disadvantage that you are married to the time point when...
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Kevin Tracey returns to the podcast to give an update about his work at the Feinstein Institutes, the field of bioelectronic medicine and exciting vagus nerve clinical trials underway
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
returns to the podcast to give an update about his work at the and the work at . Top 3 Takeaways: "Two years we discovered that a drug called Famotidine, which is sold as a generic drug Pepcid AC is actually a pharmacological or a drug-based vagus nerve stimulator. And we proved first in mice that famotidine placed directly in very small amounts placed directly in the brains of mice activates the vagus nerve. And this in turn turned off cytokine storm, which of course is a big problem in Covid 19" "A company that I've co-founded, Setpoint Medical, is currently deep into clinical trials in...
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Israel Gasperin on measuring cannabis effects quanitatively with EEG with Zentrela
Neural Implant podcast - the people behind Brain-Machine Interface revolutions
is the founder and CEO of which uses wearable EEG caps to quantitatively measure cannabis experiences. Top 3 Takeaways: "The reason why the government funded us was to use this for safety and law enforcement" "The combination of features that AI is finding is something that we haven't really focused on studying and trying to understand. It's a black box today that, is accurately and objectively characterizing the psychoactive effects, but we don't exactly know what they mean." "Based on this neuroscience-driven research proving the onset time of the beverage, within two weeks [the...
info_outlineLothar Krinke is the CEO and Board Member of Newronika which is an adaptive Deep Brain Stimulator company looking to improve patient outcomes in things like Parkinson's and Essential Tremor.
***This podcast is sponsored by Iris Biomedical, check out their Neurotech Startup Services here***
Top 3 Takeaways:
- "the one thing we do need to address is really the cost. The cost driver of Deep Brain Stimulation isn't the manufacturing of the system. Now, that's not cheap either it's certainly less than $10,000. How expensive is brain surgery, particularly functional brain surgery? How expensive is it to have all the pre-operation preparation? So I think the field needs to think about how we can lower the cost of Deep Brain Stimulation to make it available to not hundreds of thousands of patients, but literally millions of patients."
- "I don't think AI or even machine learning has been sufficiently applied in our space. People do it and they talk about it, but if you look at other fields, even EEG, use of AI or machine learning are much more penetrated."
- "In my mind it is almost unconscionable that only 15% of patients that could benefit from Parkinsons, from DBS do. So somehow we need to have a battle cry. We need to have the responsibility to make this therapy available to more people. And the way to do that is less invasive more automation and lower cost"
0:45 Do you want to introduce yourself better than I just did?
2:15 "Why is Deep Brain Simulation so exciting for you?"
3:15 "Can explain what Deep Brain Stimulation is and what it's a treatment for?"
5:30 "How did you get into the field?"
6:30 Iris Biomedical ad sponsorship
7:15 You thought earlier that DBS was too invasive but now changed your mind, why?
8:15 What are the biggest impediments to DBS?
12:15 Why is the Newronika DBS better than the alternatives?
14:30 Why is adaptive DBS better?
16:30 "What are some of the biggest challenges right now at Newronika?"
20:30 You are in Minneapolis, West Virginia, and Milan, how are you able to travel so much?
21:30 "Why aren't you in Gainesville? I was surprised how big the DBS field is here."
22:15 "For people starting out in the field, do you have any advice?"
25:30 " What's a big mistake or wrong direction that you see researchers or people on your field going down?"
27:45 "Could you explain the beta and gamma waves?"
32:45 "Is there anything that we didn't talk about that you wanted to mention?"