Can Hormone Replacement Therapy Make You Gain Weight?
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
Release Date: 05/25/2024
Menopause Ages You 9–20 Years… Unless You Do This with Nikolina Lauc
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
In this episode, I sit down with Nikolina Lauc, CEO and Co-Founder of GlycanAge, and we dive into a questions that should stop every midlife woman in her tracks: is menopause actually accelerating your biological aging? What if the shift from perimenopause to menopause could age you up to nine years in just six months? And more importantly, what can you do about it? We unpack what biological age really means (and why it’s not the same as your chronological age), how inflammation quietly drives aging and disease, and why estrogen may be one of the most powerful longevity tools we have. Is...
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Estrogen Dominance… or Estrogen Deficiency? Is It Safe to Start Estrogen in Perimenopause?
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
Welcome to the very first Hormone Hotline episode of The Hormone Solution! I’m getting straight into your real-life questions about estrogen—because why, in 2026, are we still being told we’re “estrogen dominant” with rock-bottom levels? If your doctor has warned you against HRT, this episode is for you. Have you been told you can’t start estrogen until you hit full menopause? Or that perimenopause is just too much of a “hormone rollercoaster” to treat? I break down what’s actually happening in your brain and ovaries during late perimenopause, and why adding estrogen might...
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From Toe Curling Orgasms to Healthy Poops: Why Oxytocin Is Essential for Midlife Women with Dr. Lindsey Berkson
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
What if your mood swings, anxiety, sleep issues, or loss of motivation aren’t just “getting older?” What role does oxytocin really play in midlife, and why has it been overlooked for so long? In this episode, I’m joined by the brilliant hormone scholar Dr. Lindsey Berkson, and we dive into a part of menopause that almost no one is talking about—what’s happening in your brain. We explore how hormones act as the body’s Wi‑Fi system, and what happens when that signal gets disrupted. Could environmental toxins be hijacking not just estrogen and progesterone, but oxytocin too? And...
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Inflammaging Is Hijacking Your Hormones: The Ancient Reset Women Need in Midlife with Dr. Shivani Gupta
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
Do you know whether you’re Vata, Pitta, or Kapha...and could that explain your stubborn symptoms in midlife? In this episode, I’m joined by my brilliant friend Dr. Shivani Gupta, and we dive into Ayurveda, inflammation, and why your body might be asking for a completely different approach right now. Have you ever wondered why turmeric seems to work like magic for pain, migraines, or inflammation? Or why the same routines that used to work suddenly don’t anymore in perimenopause? We unpack how ancient Ayurvedic wisdom meets modern science—and why that combination matters so much for...
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Why So Many Hormone Providers Get It Wrong (And How to Find One Who Doesn’t)
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
This episode comes straight from my own lived experience of spiraling before doctor’s appointments and feeling dismissed when it comes to hormones. I dig into why so many hormone providers get it wrong and what’s actually happening behind those rushed, frustrating conversations. Why does advocating for ourselves feel so hard? I walk you through what most doctors are (and aren’t) trained to do when it comes to perimenopause and menopause. How much of this is about lack of education versus lack of time? And how do you stop blaming yourself when you’re told your labs are “normal,”...
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Why You’re Not Healing: Stress, Insomnia, Weight Gain & the Vagus Nerve with Dr. Navaz Nabib
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
Have you’ve tried everything from protocols, to supplements, to experts and the healing still hasn’t happened? Why do so many of us stay stuck despite doing “all the right things”? In this episode, I sit down with Dr. Navaz Habib, aka "The Vagus Nerve Doc," to explore what might be missing. What if the real issue isn’t another diagnosis, hormone imbalance, or gut protocol? What if it’s your nervous system itself? I share my own journey of chasing answers and why discovering the vagus nerve made me question everything I thought I knew about healing. Why does stress seem to override...
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Why Waiting for Menopause Is a Mistake: The Case for Earlier HRT and Replacing Hormones the Right Way
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
I’m diving into why waiting until menopause to address hormones can be an incredibly costly mistake for so many women. Why are we told to “wait it out” when symptoms often start years earlier? And what’s really happening inside our bodies long before our periods stop? I walk through the often-missed perimenopausal years and explain why this phase matters more than most of us realize. What if heavy periods, anxiety, weight gain, or insomnia aren’t things you just have to tolerate? Could early hormone shifts be driving them? We also explore timing, myths, and fears around hormone...
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Why Your Gut Is Sabotaging Your Hormones (and Your Hormones Are Sabotaging Your Gut) with Kiran Krishnan
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
I’m sitting down with microbiome expert Kiran Krishnan to explore a question I see come up all the time: why do hormones sometimes stop responding the way they used to? But what if the real issue isn’t your hormones at all, rather what’s happening in your gut? In this episode, we dig into the powerful gut-hormone connection. How can gut bacteria influence estrogen metabolism, inflammation, weight gain, and even mood? Why do so many women struggle more during perimenopause and menopause despite “doing all the right things”? We also talk about why hormone therapy sometimes backfires,...
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Goodbye 2025: A Year of Healing, Hard Truths, and Growth
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
It’s time to say goodbye to 2025, so let’s get real about a year that looked successful for me on the outside, but sometimes felt like a reckoning on the inside. What happens when your body forces you to slow down? And what do you do when growth starts to cost you your peace? I open up about identity shifts, burnout, and the uncomfortable realization that I couldn’t keep working the way I was. How much of my worth was tied to helping others? What happens when you’re asked to step out of the role that once defined you? I also unpack the chaos of the menopause conversation in 2025. With...
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Part 2 Q&A with Karen: Cortisol Replacement, Optimal Levels, HRT Absorption Issues, Estrogen Detox, BIEST Troches, Perimenopause Confusion & More!
The Hormone Solution | Perimenopause, Menopause, HRT, Weight Loss & Women’s Midlife Health
This episode picks up right where part one leaves off as I dive into more of your thoughtful, honest questions in the second-part of this year-end Q&A. What happens when hormone therapy doesn’t seem to be working the way you expected? And how do you know if your dose is actually doing what you need it to do? I answer questions about achy joints, stubborn symptoms, cortisol replacement, thyroid interactions, and why some delivery methods work beautifully for one person and fail another. Why do absorption issues happen? What does “optimal” really mean when it comes to hormone levels?...
info_outlineToday, let’s talk about the correlation between hormone replacement therapy and weight gain, partially inspired by my own unexpected weight gain after starting testosterone therapy. We’ll examine the roles of estrogen, progesterone, and testosterone, examining how they can lead to both weight loss and gain, influenced by genetics and metabolism. While referencing clinical experience and research, we also discuss personalized HRT, the importance of liver health, and the impact of diet and xenoestrogens.
In this episode:
- How hormone replacement therapy (HRT) can lead to unexpected weight gain, despite its weight loss associations.
- Why progesterone's impact on thyroid function and metabolism can lead to weight changes during HRT.
- How testosterone replacement in women may cause weight gain due to genetic predispositions.
- Why estrogen replacement therapy sometimes results in initial weight gain in postmenopausal women.
- How liver health and metabolism optimization can mitigate weight gain during HRT.
- The influence of diet, alcohol consumption, and xenoestrogens on hormone balance.
- How estrogen affects body composition through receptor sensitivity.
- Why understanding the signs of hormone-related weight gain can aid in identifying hormonal imbalances.
- How excessive progesterone can lead to weight gain, water retention, and mood changes.
- Why testosterone therapy research is limited for women, but suggests it can aid in muscle maintenance.
- How estrogen alone may improve lipid profiles and reduce centralized body fat in postmenopausal women.
- Why adding testosterone to estrogen therapy can shift body composition toward increased lean mass.
- How estradiol prevents visceral fat storage and impacts hunger regulation and insulin sensitivity.
Todays show is sponsored by: Eight Sleep
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Visit www.quicksilverscientific.com/karen and use code KAREN15 for 10% off your first purchase of PushCatch® Liver Detox.
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Karen Martel, Certified Hormone Specialist & Transformational Nutrition Coach and weight loss expert.
Visit https://karenmartel.com/