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๐Ÿงฌ Targeting Aldosterone: A New Shot at Hypertension ๐ŸŽฏ๐Ÿ’ฅ show art ๐Ÿงฌ Targeting Aldosterone: A New Shot at Hypertension ๐ŸŽฏ๐Ÿ’ฅ

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ New breakthrough in hypertension care!   ๐Ÿ’Š The Launch-HTN trial shows lorundrostat โ€” a selective aldosterone synthase inhibitor โ€” significantly lowers systolic BP in patients with uncontrolled or treatment-resistant hypertension.   ๐Ÿ“‰ โˆ’16.9 mmHg vs โˆ’7.9 mmHg with placebo (P < .001) ๐Ÿงช Safe, well-tolerated, and effective across subgroups.   A potential game-changer in aldosterone-targeted therapy! ๐Ÿ”„๐Ÿ’ฅ #Hypertension #Cardiology #ClinicalTrials #PrecisionMedicine

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Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint show art Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Our latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes ๐Ÿ”ฌ๐Ÿ’Š   We explore: โœ… New diagnostic strategies โœ… Why GLP-1s & SGLT2is are game-changers โœ… How lifestyle change can lead to remission โœ… Individualizing A1C goals in real-world care   ๐ŸŽ™๏ธ Episode Title: โ€œDiagnose, Personalize, Optimize: The 2025 Diabetes Blueprintโ€ ๐Ÿ“ˆ Essential listening for clinicians, educators, and innovators in endocrine & cardiometabolic care.   ๐Ÿ‘‰ Tune in now and share with your network! #Type2Diabetes #CardiometabolicCare #GLP1 #SGLT2...

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Early to Bed, Stronger Steps Ahead ๐Ÿ’ค๐Ÿ’ช๐Ÿ‘ฃโ€ show art Early to Bed, Stronger Steps Ahead ๐Ÿ’ค๐Ÿ’ช๐Ÿ‘ฃโ€

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

How we sleep tonight shapes how we move tomorrow! ๐Ÿ“‰๐Ÿƒโ€โ™‚๏ธ In a large-scale wearable study (๐Ÿ“ฑWHOOP & Fitbit data from >25,000 adults), researchers found: โœ… Sleeping earlier than usual boosts next-day physical activity โŒ Longer or later sleep = less movement ๐Ÿ”ฅ Max gains came from consistent sleep duration + early bedtime Letโ€™s rethink our ๐Ÿ’ค to power our ๐Ÿ’ฅ! ๐Ÿ“ฃ Public health campaigns should promote sleep and exercise togetherโ€”not in competition.   ๐Ÿ“„ PNAS, June 2025 | doi:   #SleepHealth #PhysicalActivity #WearableTech #Chronobiology...

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Wrinkle, Rust, and Rewind: 17 Theories of Why We Age show art Wrinkle, Rust, and Rewind: 17 Theories of Why We Age

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿงฌ Curious why we age? ๐Ÿ•ฐ๏ธ From DNA damage to developmental programs gone rogue, this new podcast episode dives deep into 17 theories of ageing โ€” some classic, some controversial.   ๐Ÿ” We explore wear-and-tear, free radicals, telomeres, mitochondria, stem cell exhaustion, and the rising stars of epigenetic drift and hyperfunction theory.   ๐ŸŽ™๏ธ Whether youโ€™re a scientist, clinician, or just fascinated by the biology of time, tune in to uncover what really drives the ageing processโ€”and what might one day slow it down.   ๐Ÿง  Listen now: โ€œWrinkle, Rust, and...

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๐Ÿ’ฅ Beyond the Block: Cracking the Code of Chest Pain ๐Ÿ”ฌโค๏ธ show art ๐Ÿ’ฅ Beyond the Block: Cracking the Code of Chest Pain ๐Ÿ”ฌโค๏ธ

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Refractory Angina: Time to Rethink the Diagnosis ๐Ÿซ€๐Ÿ’ฅ   Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina โ€” spotlighting INOCA, CMD, vasospasm, and myocardial bridging ๐Ÿ”ฌโš™๏ธ We explore PET, CMR, CFVR, and wire-based diagnostics ๐Ÿ”Ž โ€” and why a multidisciplinary Angina Heart Team is key to transforming care ๐Ÿ‘ฉโ€โš•๏ธ๐Ÿ‘จโ€โš•๏ธ๐Ÿง  ๐ŸŽง Listen in as we chart a course from frustration to precision โ€” because even stubborn angina has a story and a solution.  ...

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Inflammaging: Myth, Marker, or Mismatch? ๐Ÿงชโ“๐ŸŒ show art Inflammaging: Myth, Marker, or Mismatch? ๐Ÿงชโ“๐ŸŒ

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿ”ฌ๐ŸŒ New insights from Nature Aging: Inflammaging isnโ€™t universal!   A fascinating cross-cultural study comparing Italy ๐Ÿ‡ฎ๐Ÿ‡น, Singapore ๐Ÿ‡ธ๐Ÿ‡ฌ, Bolivia ๐Ÿ‡ง๐Ÿ‡ด, and Malaysia ๐Ÿ‡ฒ๐Ÿ‡พ shows that age-related inflammationโ€”long considered a hallmark of agingโ€”may actually be a product of industrialized environments.   Populations like the Tsimane (Bolivia) and Orang Asli (Malaysian), despite high infection loads, show minimal correlation between cytokines and age-related disease.   ๐Ÿ“‰ Conclusion: Inflammaging is not destinyโ€”itโ€™s context.   ๐Ÿงช Read the...

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๐Ÿง โค๏ธ Predict. Prevent. Protect: AIโ€™s Lifesaving Role in HCM show art ๐Ÿง โค๏ธ Predict. Prevent. Protect: AIโ€™s Lifesaving Role in HCM

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ AI vs Sudden Cardiac Death in HCM ๐Ÿซ€๐Ÿค–   Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients.   ๐Ÿ“Š MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) ๐Ÿง  Integrated data: LGE-CMR ๐Ÿงฒ, EHR ๐Ÿ“‹, and echo/CMR reports ๐Ÿ’ป โš–๏ธ Demonstrated fairness across age and sex subgroups ๐Ÿ” Transparent predictions via Shapley values and attention heatmaps   A leap toward...

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๐Ÿ’ก Personalized, Precise, Powerful: The Rise of Cancer Vaccines ๐Ÿงช show art ๐Ÿ’ก Personalized, Precise, Powerful: The Rise of Cancer Vaccines ๐Ÿงช

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

โ€œVax to the Future: Cancer Immunity Revolution ๐Ÿงฌ๐Ÿ’‰โ€   Cancer vaccines are no longer a promise โ€” theyโ€™re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology.   ๐Ÿ“ˆ Real data from trials in melanoma, ccRCC, and pancreatic cancer โš”๏ธ PD-1 inhibitors meet targeted T cells ๐ŸŒ A safer, scalable future for cancer care   ๐ŸŽง Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI โ€” โ€œVaccines in Cancer Treatment...

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๐Ÿฌ Endothelium Under Attack: The Sweetener-Inflammation Link show art ๐Ÿฌ Endothelium Under Attack: The Sweetener-Inflammation Link

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ New Findings on Aspartame & Heart Health! ๐Ÿฌ๐Ÿซ€ A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis.   ๐Ÿงช Key insights from mice and monkeys: โ€“ Aspartame spikes insulin via vagus nerve stimulation โ€“ Elevated insulin boosts CX3CL1 expression in endothelial cells โ€“ CX3CL1 recruits inflammatory monocytes โžก๏ธ plaque growth & instability   ๐Ÿงฌ Blocking CX3CR1 in monocytes stopped plaque progression entirely....

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Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354โ€“430 CE) show art Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354โ€“430 CE)

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Saint Augustine of Hippo (354โ€“430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.

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More Episodes

๐Ÿ”ฌ Antioxidants & Health: Myths vs. Reality โŒ๐ŸŠ๐Ÿ’Š

 

Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness ๐Ÿšซโค๏ธ.

High doses of vitamin A increase the risk of hip fractures & prostate cancer โš ๏ธ๐Ÿฆด, while vitamin E is linked to respiratory infections, prostate cancer, and even death ๐Ÿ˜ทโŒ. 

However, a specific combination of antioxidants (C, E, zinc, copper, lutein, zeaxanthin) slows vision loss in age-related macular degeneration (AMD) ๐Ÿ‘๏ธ๐Ÿงก.

 

A multiomic study identified GSTO1 as the best biomarker for zinc deficiency ๐Ÿงช๐Ÿ”, but further validation is needed.

Takeaway? Antioxidants have specific benefits, but not as universal disease preventers! โš–๏ธ๐Ÿš€