loader from loading.io
Hands Down, Cream Wins! πŸ–οΈπŸ§΄πŸ’₯ Delgocitinib vs Alitretinoin in Chronic Eczema show art Hands Down, Cream Wins! πŸ–οΈπŸ§΄πŸ’₯ Delgocitinib vs Alitretinoin in Chronic Eczema

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧴 Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. πŸ“‰ Greater reduction in HECSI, 😊 better quality of life, and ⚠️ fewer side effects make it a promising non-steroidal alternative. πŸ’Š Time to rethink systemic pills β€” topical wins hands down! πŸ–οΈβœ…

info_outline
🧠🦴🚼 β€œBrains, Balance, and Birth: Cracking the Pelvic Code show art 🧠🦴🚼 β€œBrains, Balance, and Birth: Cracking the Pelvic Code

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧬 Human pelvic evolution reflects a tug-of-war between πŸšΆβ€β™€οΈ efficient walking, 🧠 growing brains, and 🚼 safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressuresβ€”not just bipedalism or birth. Larger canals ease delivery but risk πŸ’₯ pelvic floor disorders, while narrower ones boost mobility but raise ⚠️ labor complications. This study reframes the β€œobstetrical dilemma” as a πŸ”„ multifactorial evolutionary compromise.

info_outline
🫁πŸ’₯ β€œLung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸 show art 🫁πŸ’₯ β€œLung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🩸 Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin Ξ²2⁺ extracellular vesicles (sEVs) 🧬 that bind platelet GPIb 🧲, triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection 🎯, offering safer, targeted therapeutic opportunities πŸ’‰.

info_outline
Inflammation πŸ”₯, Dopamine πŸ’Š, and Apathy 😐: A Neuroimmune Pathway in Brain Fog? show art Inflammation πŸ”₯, Dopamine πŸ’Š, and Apathy 😐: A Neuroimmune Pathway in Brain Fog?

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Cancer cachexia isn’t just weight lossβ€”it’s a hijacking of motivation πŸ˜”. Elevated IL-6 πŸ”₯ activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine πŸ’Š in the nucleus accumbens, leading to effort-based apathy πŸ’€. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway πŸ’‘.

info_outline
β€œπŸ§  Fewer Strokes, 🚫 No Bleeds, βœ… Stronger Choice: Clopidogrel After PCI? show art β€œπŸ§  Fewer Strokes, 🚫 No Bleeds, βœ… Stronger Choice: Clopidogrel After PCI?

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

πŸ§ͺ SMART-CHOICE 3 in a Nutshell 🟣 Clopidogrel beat 🟠 aspirin post-PCI: πŸ“‰ Fewer MACCE (4.4% vs 6.6%) 🩸 Same bleeding risk 🍽️ Fewer GI events   ⚠️ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. 🎯 Verdict: Promisingβ€”but not bulletproof.

info_outline
Mitochondria. Medicine. Miracles show art Mitochondria. Medicine. Miracles

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

πŸ”‹ Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving πŸ«€ baby hearts to protecting 🧠 stroke-affected brains, this tiny powerhouse may revolutionize medicineβ€”one cell at a time. πŸ§¬πŸ’‰βœ¨

info_outline
 Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy show art Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle.   He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.

info_outline
Mitochondria the Tiny Travelers, Big Impact, Bold Future show art Mitochondria the Tiny Travelers, Big Impact, Bold Future

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧬 Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells πŸš€β€”healing neurons 🧠, boosting immunity πŸ›‘οΈ, and even aiding cancer cells ⚠️. Scientists are now exploring how to harness this dynamic dance for future therapies πŸ’‰.

info_outline
From Cold to Bold: The Legacy of Winter Conception show art From Cold to Bold: The Legacy of Winter Conception

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

  ❄️ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. πŸ”¬ Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 🧬 The key factor: Temperature and its diurnal variation before conception β€” not birth season β€” predicts adult brown adipose tissue (BAT) function. πŸ“‰ Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...

info_outline
β€œHeart on Fire? Timing Colchicine Right ⏳🧯πŸ₯” show art β€œHeart on Fire? Timing Colchicine Right ⏳🧯πŸ₯”

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Colchicine πŸ’Š, once a humble gout remedy, is now reshaping coronary care πŸ«€. Trials show it reduces events in stable CAD βœ…, but its benefit post-MI ⛑️ depends on timing ⏰. Inflammation matters β€” and so does when we strike. Colchicine in CAD: Small Pill, Big Debate πŸ’ŠπŸ”₯πŸ«€ An ancient anti-inflammatory has found new life in cardiology β€” reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. ⏰✨

info_outline
 
More Episodes

πŸ”¬ Antioxidants & Health: Myths vs. Reality βŒπŸŠπŸ’Š

 

Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness 🚫❀️.

High doses of vitamin A increase the risk of hip fractures & prostate cancer ⚠️🦴, while vitamin E is linked to respiratory infections, prostate cancer, and even death 😷❌. 

However, a specific combination of antioxidants (C, E, zinc, copper, lutein, zeaxanthin) slows vision loss in age-related macular degeneration (AMD) πŸ‘οΈπŸ§‘.

 

A multiomic study identified GSTO1 as the best biomarker for zinc deficiency πŸ§ͺπŸ”, but further validation is needed.

Takeaway? Antioxidants have specific benefits, but not as universal disease preventers! βš–οΈπŸš€