Hands Down, Cream Wins! ποΈπ§΄π₯ Delgocitinib vs Alitretinoin in Chronic Eczema
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧴠Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. π Greater reduction in HECSI, π better quality of life, and β οΈ fewer side effects make it a promising non-steroidal alternative. π Time to rethink systemic pills β topical wins hands down! ποΈβ
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π§ π¦΄πΌ βBrains, Balance, and Birth: Cracking the Pelvic Code
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠Human pelvic evolution reflects a tug-of-war between πΆββοΈ efficient walking, π§ growing brains, and πΌ safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressuresβnot just bipedalism or birth. Larger canals ease delivery but risk π₯ pelvic floor disorders, while narrower ones boost mobility but raise β οΈ labor complications. This study reframes the βobstetrical dilemmaβ as a π multifactorial evolutionary compromise.
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π«π₯ βLung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clotsβ π§¬π©Έ
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π©Έ Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin Ξ²2βΊ extracellular vesicles (sEVs) 𧬠that bind platelet GPIb π§², triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection π―, offering safer, targeted therapeutic opportunities π.
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Inflammation π₯, Dopamine π, and Apathy π: A Neuroimmune Pathway in Brain Fog?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Cancer cachexia isnβt just weight lossβitβs a hijacking of motivation π. Elevated IL-6 π₯ activates a brainstem-to-basal ganglia circuit π§ that suppresses dopamine π in the nucleus accumbens, leading to effort-based apathy π€. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway π‘.
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βπ§ Fewer Strokes, π« No Bleeds, β
Stronger Choice: Clopidogrel After PCI?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π§ͺ SMART-CHOICE 3 in a Nutshell π£ Clopidogrel beat π aspirin post-PCI: π Fewer MACCE (4.4% vs 6.6%) π©Έ Same bleeding risk π½οΈ Fewer GI events β οΈ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. π― Verdict: Promisingβbut not bulletproof.
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Mitochondria. Medicine. Miracles
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving π« baby hearts to protecting π§ stroke-affected brains, this tiny powerhouse may revolutionize medicineβone cell at a time. π§¬πβ¨
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Dr. RR Baligaβs Philosophical Discourses: Plato (Greece, 427β347 BCE) β Founder of the Academy
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.
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Mitochondria the Tiny Travelers, Big Impact, Bold Future
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells πβhealing neurons π§ , boosting immunity π‘οΈ, and even aiding cancer cells β οΈ. Scientists are now exploring how to harness this dynamic dance for future therapies π.
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From Cold to Bold: The Legacy of Winter Conception
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
βοΈ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. π¬ Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 𧬠The key factor: Temperature and its diurnal variation before conception β not birth season β predicts adult brown adipose tissue (BAT) function. π Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...
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βHeart on Fire? Timing Colchicine Right β³π§―π₯β
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Colchicine π, once a humble gout remedy, is now reshaping coronary care π«. Trials show it reduces events in stable CAD β , but its benefit post-MI βοΈ depends on timing β°. Inflammation matters β and so does when we strike. Colchicine in CAD: Small Pill, Big Debate ππ₯π« An ancient anti-inflammatory has found new life in cardiology β reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. β°β¨
info_outlineπ¬ Antioxidants & Health: Myths vs. Reality βππ
Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness π«β€οΈ.
High doses of vitamin A increase the risk of hip fractures & prostate cancer β οΈπ¦΄, while vitamin E is linked to respiratory infections, prostate cancer, and even death π·β.
However, a specific combination of antioxidants (C, E, zinc, copper, lutein, zeaxanthin) slows vision loss in age-related macular degeneration (AMD) ποΈπ§‘.
A multiomic study identified GSTO1 as the best biomarker for zinc deficiency π§ͺπ, but further validation is needed.
Takeaway? Antioxidants have specific benefits, but not as universal disease preventers! βοΈπ