Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
How we sleep tonight shapes how we move tomorrow! ๐๐โโ๏ธ In a large-scale wearable study (๐ฑWHOOP & Fitbit data from >25,000 adults), researchers found: โ Sleeping earlier than usual boosts next-day physical activity โ Longer or later sleep = less movement ๐ฅ Max gains came from consistent sleep duration + early bedtime Letโs rethink our ๐ค to power our ๐ฅ! ๐ฃ Public health campaigns should promote sleep and exercise togetherโnot in competition. ๐ PNAS, June 2025 | doi: #SleepHealth #PhysicalActivity #WearableTech #Chronobiology...
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๐งฌ Curious why we age? ๐ฐ๏ธ From DNA damage to developmental programs gone rogue, this new podcast episode dives deep into 17 theories of ageing โ some classic, some controversial. ๐ We explore wear-and-tear, free radicals, telomeres, mitochondria, stem cell exhaustion, and the rising stars of epigenetic drift and hyperfunction theory. ๐๏ธ Whether youโre a scientist, clinician, or just fascinated by the biology of time, tune in to uncover what really drives the ageing processโand what might one day slow it down. ๐ง Listen now: โWrinkle, Rust, and...
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Refractory Angina: Time to Rethink the Diagnosis ๐ซ๐ฅ Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina โ spotlighting INOCA, CMD, vasospasm, and myocardial bridging ๐ฌโ๏ธ We explore PET, CMR, CFVR, and wire-based diagnostics ๐ โ and why a multidisciplinary Angina Heart Team is key to transforming care ๐ฉโโ๏ธ๐จโโ๏ธ๐ง ๐ง Listen in as we chart a course from frustration to precision โ because even stubborn angina has a story and a solution. ...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐ฌ๐ New insights from Nature Aging: Inflammaging isnโt universal! A fascinating cross-cultural study comparing Italy ๐ฎ๐น, Singapore ๐ธ๐ฌ, Bolivia ๐ง๐ด, and Malaysia ๐ฒ๐พ shows that age-related inflammationโlong considered a hallmark of agingโmay actually be a product of industrialized environments. Populations like the Tsimane (Bolivia) and Orang Asli (Malaysian), despite high infection loads, show minimal correlation between cytokines and age-related disease. ๐ Conclusion: Inflammaging is not destinyโitโs context. ๐งช Read the...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ AI vs Sudden Cardiac Death in HCM ๐ซ๐ค Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. ๐ MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) ๐ง Integrated data: LGE-CMR ๐งฒ, EHR ๐, and echo/CMR reports ๐ป โ๏ธ Demonstrated fairness across age and sex subgroups ๐ Transparent predictions via Shapley values and attention heatmaps A leap toward...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
โVax to the Future: Cancer Immunity Revolution ๐งฌ๐โ Cancer vaccines are no longer a promise โ theyโre a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. ๐ Real data from trials in melanoma, ccRCC, and pancreatic cancer โ๏ธ PD-1 inhibitors meet targeted T cells ๐ A safer, scalable future for cancer care ๐ง Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI โ โVaccines in Cancer Treatment...
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๐จ New Findings on Aspartame & Heart Health! ๐ฌ๐ซ A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. ๐งช Key insights from mice and monkeys: โ Aspartame spikes insulin via vagus nerve stimulation โ Elevated insulin boosts CX3CL1 expression in endothelial cells โ CX3CL1 recruits inflammatory monocytes โก๏ธ plaque growth & instability ๐งฌ Blocking CX3CR1 in monocytes stopped plaque progression entirely....
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Saint Augustine of Hippo (354โ430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.
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๐จ Just out in JAMA! ๐ก PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation โ from LVEF to valvular disease โ with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. ๐ Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. ๐ซ๐ค A major leap toward AI-assisted cardiovascular diagnostics. ๐ #AIinMedicine #Cardiology #EchoRevolution #PanEcho #DigitalHealth #JAMA #MachineLearning #CardioAI...
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๐จ New insights from cancer neuroscience! ๐ง ๐งฌ A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes โ supercharging their metabolism, stemness, and metastatic potential ๐ช๏ธ๐ฅ Using a clever tool called MitoTRACER, researchers traced this โmitochondrial hijackโ across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases โ especially in the brain ๐งณ๐ง ๐งช Targeting this nerveโtumor energy axis may open new doors to stop...
info_outlineโ Coffee & Gut Microbiome ๐ฆ
๐ฌ A multi-cohort study (N = 22,867) found a strong link between coffee consumption and the gut bacterium Lawsonibacter asaccharolyticus.
๐งช Metabolomics identified key coffee-derived metabolites like quinic acid, hippurate, and trigonelline.
๐ Machine learning (AUC = 0.89) confirmed microbiome composition predicts coffee intake.
๐งซ In vitro studies showed coffee stimulates L. asaccharolyticus growth.
โ๏ธ Findings suggest polyphenols in coffee shape gut microbiota and metabolic pathways.
๐ Future research aims to explore dose-dependent effects, health benefits, and microbiome-driven nutrition.