Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π§ͺ SMART-CHOICE 3 in a Nutshell π£ Clopidogrel beat π aspirin post-PCI: π Fewer MACCE (4.4% vs 6.6%) π©Έ Same bleeding risk π½οΈ Fewer GI events β οΈ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. π― Verdict: Promisingβbut not bulletproof.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
π Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving π« baby hearts to protecting π§ stroke-affected brains, this tiny powerhouse may revolutionize medicineβone cell at a time. π§¬πβ¨
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells πβhealing neurons π§ , boosting immunity π‘οΈ, and even aiding cancer cells β οΈ. Scientists are now exploring how to harness this dynamic dance for future therapies π.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
βοΈ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. π¬ Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 𧬠The key factor: Temperature and its diurnal variation before conception β not birth season β predicts adult brown adipose tissue (BAT) function. π Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
Colchicine π, once a humble gout remedy, is now reshaping coronary care π«. Trials show it reduces events in stable CAD β , but its benefit post-MI βοΈ depends on timing β°. Inflammation matters β and so does when we strike. Colchicine in CAD: Small Pill, Big Debate ππ₯π« An ancient anti-inflammatory has found new life in cardiology β reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. β°β¨
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
πΏ Switching to a Western diet π increased inflammation π₯ and metabolic dysfunction. π Mbege and traditional foods calmed the immune system π§ and boosted IL-10 ποΈ.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
Not all salts are created equal! π§ Sodium chloride raises blood pressure and harms the heart π, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients π‘οΈπ«. Chloride channels (CLICs) play a hidden but vital role in heart health πβ€οΈ. We need large RCTs π§ͺπ to guide smarter, personalized salt strategies for better cardiovascular care π―π.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
The SOUL trial π§ͺ showed that oral semaglutide π significantly reduced major cardiovascular events β€οΈ (MACE) in people with type 2 diabetes π©Έ and ASCVD/CKD π. Over ~4 years, it cut heart attacks π₯, lowered HbA1c π, reduced weight βοΈ, and inflammation π₯ β all with a once-daily pill ποΈ and no rise in serious side effects.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
Mozi, a prominent Chinese philosopher during the Warring States period, founded Mohism, a school of thought emphasizing universal love, meritocracy, anti-war principles, and consequentialist ethics. He advocated for frugality, social welfare, and pragmatic governance guided by Heavenβs will.
info_outlineπ§ Brain Aging & Research Advances
π Key Findings:
β’ Brain Age Gap (BAG): Difference between estimated and chronological brain age.
β’ 64 genes identified as influencing brain aging.
β’ 13 proteins in blood linked to accelerated/slowed brain aging.
π©Ί Potential Interventions:
β’ 13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing decline.
β’ Plasma proteomics reveals key biomarkers for early intervention.
π Influencing Factors:
β’ Socioeconomic status, pollution, and gender inequality impact brain aging.
β’ Functional connectivity decline linked to cognitive disorders.
π Future Directions:
β’ Clinical trials needed for drug validation.
β’ Genetic & proteomic studies should expand to diverse populations.