Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ AI vs Sudden Cardiac Death in HCM ๐ซ๐ค Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. ๐ MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) ๐ง Integrated data: LGE-CMR ๐งฒ, EHR ๐, and echo/CMR reports ๐ป โ๏ธ Demonstrated fairness across age and sex subgroups ๐ Transparent predictions via Shapley values and attention heatmaps A leap toward...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
โVax to the Future: Cancer Immunity Revolution ๐งฌ๐โ Cancer vaccines are no longer a promise โ theyโre a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. ๐ Real data from trials in melanoma, ccRCC, and pancreatic cancer โ๏ธ PD-1 inhibitors meet targeted T cells ๐ A safer, scalable future for cancer care ๐ง Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI โ โVaccines in Cancer Treatment...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ New Findings on Aspartame & Heart Health! ๐ฌ๐ซ A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. ๐งช Key insights from mice and monkeys: โ Aspartame spikes insulin via vagus nerve stimulation โ Elevated insulin boosts CX3CL1 expression in endothelial cells โ CX3CL1 recruits inflammatory monocytes โก๏ธ plaque growth & instability ๐งฌ Blocking CX3CR1 in monocytes stopped plaque progression entirely....
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
Saint Augustine of Hippo (354โ430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ Just out in JAMA! ๐ก PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation โ from LVEF to valvular disease โ with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. ๐ Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. ๐ซ๐ค A major leap toward AI-assisted cardiovascular diagnostics. ๐ #AIinMedicine #Cardiology #EchoRevolution #PanEcho #DigitalHealth #JAMA #MachineLearning #CardioAI...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ New insights from cancer neuroscience! ๐ง ๐งฌ A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes โ supercharging their metabolism, stemness, and metastatic potential ๐ช๏ธ๐ฅ Using a clever tool called MitoTRACER, researchers traced this โmitochondrial hijackโ across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases โ especially in the brain ๐งณ๐ง ๐งช Targeting this nerveโtumor energy axis may open new doors to stop...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐ง ๐ Cognitive decline and cardiovascular disease often go hand in hand โ but they donโt have to spiral together. In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-based care โ itโs time to connect the mind and the heart. ๐ Evidence-based strategies ๐ฉบ Practical tools for clinicians ๐ก Insights from JACCโs state-of-the-art review ๐ Letโs build heart-smart,...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐ง ๐ Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementiaโpossibly by stimulating immune pathways like IFN-ฮณ and TLR4, not just by preventing infection. ๐ In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-month dementia risk than flu-vaccinated peers. ๐ฌ The common thread? The AS01 adjuvant. ๐ก๏ธ Could this be a new frontier in neuroprotection? Letโs discuss. #Vaccines #Dementia #RSV #AS01 #Neuroimmunology...
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
New Insights from the DanGer Shock Trial! ๐ซ๐ก Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressuresโall while using less pharmacologic support. ๐๐ ๐งช Native CO improved steadily over 48 hours, hinting at myocardial recovery. ๐ PAC data gives us a front-row seat to the physiology behind the survival curves. ๐ฌ The editorial dives deeper: timing, technique, and future questions....
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐จ New Breakthrough in Type 2 Diabetes Care! ๐๐งฌ The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weightโwithout injections and with minimal restrictions! ๐๐ ๐จโโ๏ธ 559 patients across 5 countries โฑ๏ธ 40 weeks, 3 dosing arms (3, 12, 36 mg) ๐ HbA1c โ by up to 1.48%, weight โ up to 7.6% โ No severe hypoglycemia ๐ Mild GI side effects during dose titration This is a potential gamechanger for early T2DM careโsimple, effective, and...
info_outline๐ TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! ๐
โ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib
๐ช Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD