Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Exciting new insights from Science Translational Medicine (2025)! Researchers uncovered how the GAS6βAXLβFAK axis determines whether wounds heal with scars or regeneration. π§¬π π‘ Activating AXL with GAS6 rewires fibrotic healing into scarless repair β especially in the oral mucosa. π₯ Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues. This could revolutionize how we approach scar prevention and tissue regeneration. π©Ήβ¨ #RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq...
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βπ Is your daily brew helping or harming your heart? New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1β4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality. 𧬠Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles. β οΈ But beware: excessive intake and unfiltered brews may raise LDL. π Great read for clinicians navigating patient questions on coffee and...
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π§ 𧬠New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity. A youthful brain and immune system cut mortality risk nearly in halfβmore so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine. π Machine learning + blood proteins = next-gen aging biomarkers. π Study link: https://doi.org/10.1038/s41591-025-03798-1 #Longevity #Proteomics #BrainHealth #ImmuneSystem #Aging #Biomarkers #PrecisionMedicine #UKBiobank...
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π£ New insights from a global study on cardiovascular disease! πβ€οΈ Even without traditional risk factors, your lifetime risk of CVD isnβt zero β but midlife action can add a decade or more of healthy life. π§ π‘ Key takeaway: Knowing is not enough β we must apply. π©Ίπβ #CardiovascularHealth #PreventionMatters #GlobalHealth #PrecisionMedicine #PublicHealth πͺππ§¬
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π¬ Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 𧬠Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depotsβyet some immune memory lingers. π§ π₯ A compelling case for adipose plasticityβand why cellular βmemoryβ may be the key to sustained metabolic health. π‘πͺ #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence #PrecisionMedicine #Nature
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π§ π Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells β a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. π¬β€οΈβπ₯ #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism
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πΎ New Research Alert! π§ Owning a dog or cat may do more than warm your heart β it could help preserve your mind! πΆπ± A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency. π§ͺ No boost seen with fish or birds π π¦, but fur friends = brain gains! π Letβs rethink aging β with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth π§π‘
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π§ β¨ New Stroke Breakthrough! The ASSET-IT trial shows that early infusion of tirofiban after thrombolysis significantly boosts recovery in noncardioembolic stroke patients β with 65.9% achieving excellent outcomes at 90 days vs 54.9% with placebo ππ β Improved function β οΈ Slightly higher bleeding risk π Study conducted across 38 centers in China π Read the trial in NEJM (July 2025) #Stroke #Tirofiban #Neurology #RCT #PrecisionMedicine #Thrombolysis #CardiovascularResearch
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πβ¨ Just explored Boethius: The Consolation of Philosophy β a timeless journey from despair to divine reason. Written in prison, this masterpiece blends Roman philosophy with Nicene Christian theology, standing firm against Arianism. ποΈβοΈ π§ Listen now: #Boethius #Theology #FaithAndReason #Podcast π‘ποΈπ
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π‘ New Study Alert! πββοΈπ§ͺ Kidney-derived betaine mimics long-term exerciseβblocking TBK1, reducing inflammation, and reversing aging markers. This multi-omics human + mouse study uncovers betaine as a precision geroprotector for those who canβt hit the gym. π A leap toward exercise mimetics in aging science! #Geroprotection #PrecisionMedicine #ExerciseScience #Betaine π§¬π§π₯
info_outlineπ¨ New trial alert! In youth with type 1 diabetes, adding #SGLT2i π (dapagliflozin) to insulin:
β Reduced glomerular hyperfiltration
β Lowered HbA1c π
β Boosted time-in-range β±οΈ
π Safe with DKA precautions in place
π #ATTEMPTTrial | @NatureMedicine
π https://doi.org/10.1038/s41591-025-03723-6