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๐Ÿง โค๏ธ Predict. Prevent. Protect: AIโ€™s Lifesaving Role in HCM show art ๐Ÿง โค๏ธ Predict. Prevent. Protect: AIโ€™s Lifesaving Role in HCM

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ AI vs Sudden Cardiac Death in HCM ๐Ÿซ€๐Ÿค–   Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients.   ๐Ÿ“Š MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) ๐Ÿง  Integrated data: LGE-CMR ๐Ÿงฒ, EHR ๐Ÿ“‹, and echo/CMR reports ๐Ÿ’ป โš–๏ธ Demonstrated fairness across age and sex subgroups ๐Ÿ” Transparent predictions via Shapley values and attention heatmaps   A leap toward...

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๐Ÿ’ก Personalized, Precise, Powerful: The Rise of Cancer Vaccines ๐Ÿงช show art ๐Ÿ’ก Personalized, Precise, Powerful: The Rise of Cancer Vaccines ๐Ÿงช

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

โ€œVax to the Future: Cancer Immunity Revolution ๐Ÿงฌ๐Ÿ’‰โ€   Cancer vaccines are no longer a promise โ€” theyโ€™re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology.   ๐Ÿ“ˆ Real data from trials in melanoma, ccRCC, and pancreatic cancer โš”๏ธ PD-1 inhibitors meet targeted T cells ๐ŸŒ A safer, scalable future for cancer care   ๐ŸŽง Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI โ€” โ€œVaccines in Cancer Treatment...

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๐Ÿฌ Endothelium Under Attack: The Sweetener-Inflammation Link show art ๐Ÿฌ Endothelium Under Attack: The Sweetener-Inflammation Link

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ New Findings on Aspartame & Heart Health! ๐Ÿฌ๐Ÿซ€ A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis.   ๐Ÿงช Key insights from mice and monkeys: โ€“ Aspartame spikes insulin via vagus nerve stimulation โ€“ Elevated insulin boosts CX3CL1 expression in endothelial cells โ€“ CX3CL1 recruits inflammatory monocytes โžก๏ธ plaque growth & instability   ๐Ÿงฌ Blocking CX3CR1 in monocytes stopped plaque progression entirely....

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Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354โ€“430 CE) show art Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354โ€“430 CE)

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Saint Augustine of Hippo (354โ€“430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.

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Beats, Bytes, Brilliance ๐Ÿซ€๐Ÿ’พ๐ŸŒŸ: The Rise of AI in Echocardiography show art Beats, Bytes, Brilliance ๐Ÿซ€๐Ÿ’พ๐ŸŒŸ: The Rise of AI in Echocardiography

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ Just out in JAMA!   ๐Ÿ’ก PanEcho, a multitask AI model trained on over 1.2 million echo videos, can automate complete echocardiographic interpretation โ€” from LVEF to valvular disease โ€” with diagnostic AUCs up to 1.00 and MAE as low as 4.2%. ๐ŸŒ Validated across international cohorts, including point-of-care settings, this tool could redefine access, accuracy, and efficiency in cardiac imaging. ๐Ÿซ€๐Ÿค– A major leap toward AI-assisted cardiovascular diagnostics.   ๐Ÿ”— #AIinMedicine #Cardiology #EchoRevolution #PanEcho #DigitalHealth #JAMA #MachineLearning #CardioAI...

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๐Ÿ”Œ Power Heist in the Tumor: Neurons Fuel Cancer Spread show art ๐Ÿ”Œ Power Heist in the Tumor: Neurons Fuel Cancer Spread

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ New insights from cancer neuroscience! ๐Ÿง ๐Ÿงฌ A groundbreaking Nature study reveals that cancer cells can steal mitochondria from nearby neurons via tunneling nanotubes โ€” supercharging their metabolism, stemness, and metastatic potential ๐ŸŒช๏ธ๐Ÿ’ฅ   Using a clever tool called MitoTRACER, researchers traced this โ€œmitochondrial hijackโ€ across cancers (breast, prostate, melanoma) and showed that recipient cells were more likely to seed distant metastases โ€” especially in the brain ๐Ÿงณ๐Ÿง    ๐Ÿงช Targeting this nerveโ€“tumor energy axis may open new doors to stop...

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๐Ÿง ๐Ÿ’ก Memory Matters: A Cardiologistโ€™s Guide to Cognitive Care show art ๐Ÿง ๐Ÿ’ก Memory Matters: A Cardiologistโ€™s Guide to Cognitive Care

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿง ๐Ÿ’“ Cognitive decline and cardiovascular disease often go hand in hand โ€” but they donโ€™t have to spiral together.   In our latest breakdown, we explore how cardiologists can detect, manage, and even improve cognitive impairment through smart risk factor control, lifestyle changes, and a multidisciplinary approach. From MoCA to memantine, TAVR to team-based care โ€” itโ€™s time to connect the mind and the heart.   ๐Ÿ“Š Evidence-based strategies ๐Ÿฉบ Practical tools for clinicians ๐Ÿ’ก Insights from JACCโ€™s state-of-the-art review   ๐Ÿ‘‰ Letโ€™s build heart-smart,...

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Adjuvants & Alzheimerโ€™s: A Shot at Prevention ๐Ÿ’ฅ๐Ÿงฌ๐Ÿง  show art Adjuvants & Alzheimerโ€™s: A Shot at Prevention ๐Ÿ’ฅ๐Ÿงฌ๐Ÿง 

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿง ๐Ÿ’‰ Can vaccines protect the mind? New research suggests that AS01-adjuvanted vaccines like Shingrix and Arexvy may reduce the risk of dementiaโ€”possibly by stimulating immune pathways like IFN-ฮณ and TLR4, not just by preventing infection.   ๐Ÿ“Š In a large US-based EHR study, those who received the RSV or shingles vaccine had a significantly lower 18-month dementia risk than flu-vaccinated peers.   ๐Ÿ”ฌ The common thread? The AS01 adjuvant.   ๐Ÿ›ก๏ธ Could this be a new frontier in neuroprotection? Letโ€™s discuss. #Vaccines #Dementia #RSV #AS01 #Neuroimmunology...

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๐Ÿ’‰ Pump, ๐Ÿ“‰ Pressure, โšก Power: Inside the STEMI Shock Solution show art ๐Ÿ’‰ Pump, ๐Ÿ“‰ Pressure, โšก Power: Inside the STEMI Shock Solution

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

New Insights from the DanGer Shock Trial! ๐Ÿซ€๐Ÿ’ก   Can early left ventricular unloading with a microaxial flow pump (mAFP) save lives in STEMI-related cardiogenic shock? This compelling substudy shows that mAFP not only boosts cardiac output and power, but also reduces pulmonary pressuresโ€”all while using less pharmacologic support. ๐Ÿ“‰๐Ÿ’Š   ๐Ÿงช Native CO improved steadily over 48 hours, hinting at myocardial recovery. ๐Ÿ“Š PAC data gives us a front-row seat to the physiology behind the survival curves. ๐Ÿ”ฌ The editorial dives deeper: timing, technique, and future questions....

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๐ŸŒ ACHIEVE-1 Decoded: Efficacy & Safety of Orforglipron in Type 2 Diabetes show art ๐ŸŒ ACHIEVE-1 Decoded: Efficacy & Safety of Orforglipron in Type 2 Diabetes

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

๐Ÿšจ New Breakthrough in Type 2 Diabetes Care! ๐Ÿ’Š๐Ÿงฌ The ACHIEVE-1 trial shows that Orforglipron, a once-daily oral, nonpeptide GLP-1 receptor agonist, delivers significant reductions in HbA1c and body weightโ€”without injections and with minimal restrictions! ๐ŸŒ๐Ÿ“‰   ๐Ÿ‘จโ€โš•๏ธ 559 patients across 5 countries โฑ๏ธ 40 weeks, 3 dosing arms (3, 12, 36 mg) ๐Ÿ“Š HbA1c โ†“ by up to 1.48%, weight โ†“ up to 7.6% โœ… No severe hypoglycemia ๐Ÿ“Œ Mild GI side effects during dose titration   This is a potential gamechanger for early T2DM careโ€”simple, effective, and...

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More Episodes

๐Ÿšจ New trial alert! In youth with type 1 diabetes, adding #SGLT2i ๐Ÿ’Š (dapagliflozin) to insulin:

โœ… Reduced glomerular hyperfiltration

โœ… Lowered HbA1c ๐Ÿ“‰

โœ… Boosted time-in-range โฑ๏ธ

๐Ÿ˜Œ Safe with DKA precautions in place

๐Ÿ“„ #ATTEMPTTrial | @NatureMedicine

๐Ÿ”— https://doi.org/10.1038/s41591-025-03723-6