Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐ฌ New Review Alert! ๐ซ South Asians face one of the highest global burdens of premature heart disease โ and Lp(a) may be the silent culprit. ๐ In a comprehensive JAHA 2025 review, researchers reveal how 25% of South Asians have dangerously elevated Lp(a) levels, doubling their risk of myocardial infarction. ๐งฌ๐ฅ Key takeaways: โ Lp(a) is genetically driven & unaffected by lifestyle โ Risk is underestimated by standard calculators โ Novel therapies (PCSK9i, siRNA, ASOs) are on the horizon โ One-time testing is now strongly recommended in all South Asians...
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๐ข New insights on education & brain aging! ๐ง ๐ A mega-analysis across 33 countries (170K+ participants, 15K+ MRIs) shows ๐ higher education boosts baseline memoryโbut doesnโt slow brain aging or cognitive decline over time. โ๐ง โ Early-life traits (like childhood cognition & environment) drive the advantage. ๐ Education mattersโbut not in the way we thought. Full story: โReevaluating the role of education on cognitive decline and brain agingโ in Nature Medicine ๐งฌ๐ #CognitiveHealth #BrainAging #LifelongLearning...
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๐งฌ Just dropped: our latest podcast episode ๐๏ธ dives into Lipoprotein(a) and its powerful role in predicting vascular disease beyond the heart ๐ซโincluding PAD ๐ฆต and stroke ๐ง . ๐ Based on a massive UK Biobank study (n=460K+), high Lp(a) levels (โฅ150 nmol/L) were linked to: โข 18% โ risk of PAD โข 17% โ risk of carotid stenosis โข 60% โ risk of major limb events โ ๏ธ Lp(a) is more than a lab valueโitโs a Vascular Crystal Ball. #LipoproteinA #PAD #Stroke #VascularMedicine #PrecisionCardiology #CardioPodcast #Biomarkers #Atherosclerosis...
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๐ง โจ Dive into the mind of Avicenna (Ibn Sina) โ the Persian polymath who shaped medicine, metaphysics, and logic for centuries. From the Canon of Medicine to the Book of Healing, his legacy lives on in modern science and thought. ๐๐ #Philosophy #Medicine #Avicenna
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๐ข New Data Drop! ๐ซ๐ฅ South Asian adults in the U.S. have an earlier and sharper rise in coronary artery calcium (CAC) โ a silent marker of heart disease risk! ๐ฎ๐ณ๐ In a first-of-its-kind study combining MASALA & DILWALE cohorts (n=2,743), 65% of South Asian men and 30% of women had CAC >0 by age 55 โ and women catch up fast after menopause. ๐นโก๏ธ๐บ ๐ Sex-specific CAC percentiles = smarter screening, better prevention. ๐ก Time to rethink traditional risk calculators for this high-risk group. ๐๏ธ Podcast title: โMen First, Women...
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๐จ New Insights from Nature Medicine ๐ง ๐ Can cookies and chips hijack your brain like cocaine? A compelling new article argues that ultra-processed food addiction mirrors classic substance use disorders โ down to the cravings, compulsive use, and reward circuit disruption. With GLP-1 drugs bridging obesity and addiction treatment, is it time the DSM-5 recognized food addiction? ๐งฌ Science says yes. โ๏ธ Policy is lagging. ๐ข Letโs start the conversation. #FoodAddiction #UltraProcessedFoods #DSM5 #GLP1 #PublicHealth #Neuroscience #Obesity #HealthPolicy...
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๐จ New Hypertension Guidance Alert! ๐ฉบ๐ก The British & Irish Hypertension Society now recommends treating all adults with sustained BP โฅ135/85 mmHgโregardless of CVD riskโand targeting <130/80 mmHg within 6 months. No more waiting for risk scores to rise ๐โณ. This bold, evidence-backed move aligns with global trends ๐ and aims to end therapeutic inertia for good. Letโs make treatment simpler, safer, and sooner! ๐โ #Hypertension #Guidelines #PrimaryCare #Cardiology #PublicHealth
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๐ง ๐โโ๏ธ Can running rewire the Alzheimerโs brain? New study in Nature Neuroscience shows how exercise transforms cell-specific gene expression in the dentate gyrus of AD mice! Using single-nucleus RNA-seq, researchers found that voluntary running reversed transcriptional dysregulation in key cell typesโespecially immature neurons, astrocytes, and microglia. ๐กHighlights: โ Neurogenesis boosted โ Disease-associated microglia reprogrammed โ Novel astrocyte subpopulation rescued This could pave the way for targeted therapeutics rooted in the biology of...
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๐จ Statins & Diabetes: Dose Matters, But So Does Perspective ๐๐ A 2024 CTT Collaboration meta-analysis of 154,664 participants confirms: โ Statins modestly increase risk of diabetes (10% with moderate, 36% with high-intensity) ๐ Small upticks in HbA1c and glucose ๐งช But most new cases were already teetering near the threshold ๐ฉบ Bottom line? Cardiovascular benefits far outweigh the diabetes risk. ๐ก Itโs a reminder: precision prevention is about balancing risk, not eliminating it. ๐ Ref: Lancet Diabetes Endocrinol 2024 | DOI: #Statins #Diabetes...
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๐งฌ Just explored a groundbreaking 50-year proteomic atlas that charts how our proteins evolve with age across 13 human tissues! ๐ง Key insights? Aging inflection around 50, transcriptome-proteome decoupling, amyloid buildup, and senoproteins like GAS6 & GPNMB driving vascular & systemic aging. ๐ Proteomic clocks, plasma biomarkers, and tissue-specific aging maps may redefine how we measure and manage aging. ๐ Dive into the protein-powered future of aging science! #Proteomics #AgingResearch #Biomarkers #Senescence #PrecisionMedicine
info_outline๐ Big win for kidneys! In the CONFIDENCE trial, combo therapy with #Finerenone + #Empagliflozin ๐ slashed albuminuria 29โ32% more than either alone in CKD + T2D patients ๐งช๐ก๏ธ
Safe, fast, and promising! ๐ฅโฑ๏ธโ
#Nephrology #CardioRenal #SGLT2i #NEJM ๐งฌ๐ฉบ