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💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart show art 💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓 Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️   From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉   🧠 A must-read for cardiologists, immunologists & translational researchers! 📄 Wang et al., Sci. Transl. Med. 2025 🔗 #Cardiology #HCM #TREG #Immunotherapy #Fibrosis #PrecisionMedicine...

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💤🧠 Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease show art 💤🧠 Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧠💤 Just dropped our latest Got Knowledge Doc podcast: “Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease” 🧬🎧   We explore how the brain’s nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it’s a story of sleep, science, and hope. 🌙🔬   Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer’s. 🧪🧩   #AlzheimersDisease #GlymphaticSystem #Neuroscience #SleepScience...

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Gut Talks to the Heart 🥗💓🧠: The Incretin Connection show art Gut Talks to the Heart 🥗💓🧠: The Incretin Connection

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Podcast Episode! 🎙️ “Gut Talks to the Heart 🥗💓🧠: The Incretin Connection”   Did you know that GLP-1 and GIP do far more than control blood sugar? These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline.   💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism.   🔗 Tune in to learn how your next meal could be triggering an endocrine symphony.   #Cardiology #Endocrinology #Incretins #GLP1 #GIP...

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👄 Mouths Heal Better: What Your Skin Can Learn from Oral Wounds show art 👄 Mouths Heal Better: What Your Skin Can Learn from Oral Wounds

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Exciting new insights from Science Translational Medicine (2025)!   Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉   💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa. 💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues.   This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨   #RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq...

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☕ Evidence Per Cup: Coffee and Cardiovascular Outcomes show art ☕ Evidence Per Cup: Coffee and Cardiovascular Outcomes

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

☕💓 Is your daily brew helping or harming your heart?   New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1–4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality.   🧬 Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles. ⚠️ But beware: excessive intake and unfiltered brews may raise LDL.   📊 Great read for clinicians navigating patient questions on coffee and...

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Longevity’s Guardians?: The Brain and Immune System Duo show art Longevity’s Guardians?: The Brain and Immune System Duo

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧠🧬 New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity.   A youthful brain and immune system cut mortality risk nearly in half—more so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine.   📊 Machine learning + blood proteins = next-gen aging biomarkers. 🔗 Study link: https://doi.org/10.1038/s41591-025-03798-1   #Longevity #Proteomics #BrainHealth #ImmuneSystem #Aging #Biomarkers #PrecisionMedicine #UKBiobank...

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Five to Thrive: Slash Your Cardiovascular Disease Risk ✋🛡️🧬 show art Five to Thrive: Slash Your Cardiovascular Disease Risk ✋🛡️🧬

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

📣 New insights from a global study on cardiovascular disease! 🌍❤️   Even without traditional risk factors, your lifetime risk of CVD isn’t zero — but midlife action can add a decade or more of healthy life. 🧠💡   Key takeaway: Knowing is not enough — we must apply. 🩺📊✅ #CardiovascularHealth #PreventionMatters #GlobalHealth #PrecisionMedicine #PublicHealth 💪🌎🧬

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Fat Depot Drama: From Swell to Well 🏕️📉😊 show art Fat Depot Drama: From Swell to Well 🏕️📉😊

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🔬 Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 🧬 Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depots—yet some immune memory lingers. 🧠🔥   A compelling case for adipose plasticity—and why cellular “memory” may be the key to sustained metabolic health. 💡💪 #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence #PrecisionMedicine #Nature

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Sugar Switches: HFpEF’s Hidden Code 🧩🫀🧬 show art Sugar Switches: HFpEF’s Hidden Code 🧩🫀🧬

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF!   Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️‍🔥   #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism

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Cats, Dogs, and Clarity 🐕🐈💡: The Cognitive Perks of Pet Ownership show art Cats, Dogs, and Clarity 🐕🐈💡: The Cognitive Perks of Pet Ownership

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🐾 New Research Alert! 🧠 Owning a dog or cat may do more than warm your heart — it could help preserve your mind! 🐶🐱 A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency.   🧪 No boost seen with fish or birds 🐠🐦, but fur friends = brain gains! 🔗 Let’s rethink aging — with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth 🧓💡

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More Episodes

🔥 Immunosenescence + Inflammaging = Aging’s hidden engines.

🧬 New studies link immune decline to frailty, dementia, and disease.

🥗💉 Sleep, diet, vaccines, and GLP-1s may slow the clock.

#Healthspan > #Lifespan 💡👴🛡️

Derived from Dr. Eric Topol’s Ground Truths on Substack.