Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓 Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️ From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉 🧠 A must-read for cardiologists, immunologists & translational researchers! 📄 Wang et al., Sci. Transl. Med. 2025 🔗 #Cardiology #HCM #TREG #Immunotherapy #Fibrosis #PrecisionMedicine...
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🧠💤 Just dropped our latest Got Knowledge Doc podcast: “Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease” 🧬🎧 We explore how the brain’s nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it’s a story of sleep, science, and hope. 🌙🔬 Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer’s. 🧪🧩 #AlzheimersDisease #GlymphaticSystem #Neuroscience #SleepScience...
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🚨 New Podcast Episode! 🎙️ “Gut Talks to the Heart 🥗💓🧠: The Incretin Connection” Did you know that GLP-1 and GIP do far more than control blood sugar? These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline. 💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism. 🔗 Tune in to learn how your next meal could be triggering an endocrine symphony. #Cardiology #Endocrinology #Incretins #GLP1 #GIP...
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Exciting new insights from Science Translational Medicine (2025)! Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉 💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa. 💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues. This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨ #RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq...
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☕💓 Is your daily brew helping or harming your heart? New evidence from a comprehensive European Heart Journal review suggests that moderate coffee consumption (1–4 cups/day) is linked to reduced risks of hypertension, type 2 diabetes, coronary artery disease, heart failure, stroke, and even mortality. 🧬 Benefits often persist regardless of caffeine content, and filtered coffee appears safest for lipid profiles. ⚠️ But beware: excessive intake and unfiltered brews may raise LDL. 📊 Great read for clinicians navigating patient questions on coffee and...
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🧠🧬 New research alert! Plasma proteomics from 44,000+ UK Biobank participants reveals that the brain and immune system are powerful predictors of longevity. A youthful brain and immune system cut mortality risk nearly in half—more so than any other organ. This could reshape how we think about aging, diagnostics, and preventive medicine. 📊 Machine learning + blood proteins = next-gen aging biomarkers. 🔗 Study link: https://doi.org/10.1038/s41591-025-03798-1 #Longevity #Proteomics #BrainHealth #ImmuneSystem #Aging #Biomarkers #PrecisionMedicine #UKBiobank...
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📣 New insights from a global study on cardiovascular disease! 🌍❤️ Even without traditional risk factors, your lifetime risk of CVD isn’t zero — but midlife action can add a decade or more of healthy life. 🧠💡 Key takeaway: Knowing is not enough — we must apply. 🩺📊✅ #CardiovascularHealth #PreventionMatters #GlobalHealth #PrecisionMedicine #PublicHealth 💪🌎🧬
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🔬 Just read a fascinating News & Views in Nature on how weight loss reshapes adipose tissue beyond just shedding fat! 🧬 Using single-nucleus RNA-seq and spatial profiling, researchers found that bariatric surgery reverses stress, inflammation, and senescence in fat depots—yet some immune memory lingers. 🧠🔥 A compelling case for adipose plasticity—and why cellular “memory” may be the key to sustained metabolic health. 💡💪 #ObesityResearch #AdiposeRemodeling #WeightLossScience #Senescence #PrecisionMedicine #Nature
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🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism
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🐾 New Research Alert! 🧠 Owning a dog or cat may do more than warm your heart — it could help preserve your mind! 🐶🐱 A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency. 🧪 No boost seen with fish or birds 🐠🐦, but fur friends = brain gains! 🔗 Let’s rethink aging — with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth 🧓💡
info_outline🔥 Immunosenescence + Inflammaging = Aging’s hidden engines.
🧬 New studies link immune decline to frailty, dementia, and disease.
🥗💉 Sleep, diet, vaccines, and GLP-1s may slow the clock.
#Healthspan > #Lifespan 💡👴🛡️
Derived from Dr. Eric Topol’s Ground Truths on Substack.