“From Gut to Heart: Microbes, Metabolites & Myeloid Mayhem 🦠➡️🧬🔥”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬 New Insights into Gut–Heart Axis 🫀💡 Groundbreaking research published in Nature shows that Imidazole propionate (ImP)—a metabolite produced by gut bacteria—drives atherosclerosis by hijacking immune pathways in myeloid cells via the I1R–mTORC1 axis 🔥🧫. 📈 Elevated ImP levels predicted subclinical atherosclerosis independently of cholesterol in two large cohorts (PESA & IGT). 💊 Blocking this pathway with AGN192403 prevented plaque buildup—offering a novel, cholesterol-independent therapeutic target. 📚 Time to rethink cardiovascular...
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🧬 Mito Moms. Safe Starts. Healthy Babies. The Promise of Mitochondrial Donation
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Podcast Alert! 🎙️🧬 Curious about how modern medicine is tackling devastating mitochondrial DNA diseases like MELAS, LHON, and NARP? Our latest podcast dives into four landmark NEJM articles covering cutting-edge advances—from embryo screening (PGT) to groundbreaking mitochondrial replacement therapy (MRT). 🧪👶 Join us as we explore science, ethics, and hope at the frontier of germline medicine.⚖️💡 #MitochondrialMedicine #Genetics #PrecisionMedicine #ReproductiveHealth #NEJM #Podcast #PGT #PNT #Bioethics #ThreeParentBaby
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Flatlines to Frontlines ⚡️🫀🧬: ECG-AI Fusion Detect Structural Heart Disease
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 AI meets ECG 🧠⚡ New insights show that a simple ECG — when powered by deep learning — can detect structural heart diseases like LV systolic dysfunction, HCM, and aortic stenosis with AUROCs >0.90! 🫀📈 📊 Sample size: 54,000+ | NPV >98% | p < 0.001 ✅ Low-cost, non-invasive, high-accuracy screening? Yes, please. 🧠 Time to rethink the ECG as a frontline diagnostic tool. #Cardiology #ArtificialIntelligence #ECG #StructuralHeartDisease #DigitalHealth #MedTech #MachineLearning #HCM #LVSD #AorticStenosis #Innovation #PrecisionMedicine #HealthcareAI...
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🤔Pee Points & Prostate Problems: What Docs Should Know
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
New Podcast Episode Alert! 🎙️ “💧Block, Burst, or Both?💥 Understanding Male LUTS” Up to 40% of men over 50 face lower urinary tract symptoms—from weak stream to nocturia. This week, we unpack the landmark JAMA 2025 review by Drs. Wei, Dauw, and Brodsky. 🧠💊 Tune in as we explore: 🔹 BPH vs Overactive Bladder 🔹 When to treat—and how 🔹 Meds, muscles, and minimally invasive magic 🔹 What every clinician should know before referring 🚑 🎧 Whether you’re a primary care doc, urologist, or just curious—this episode is worth the wait....
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Wall Thick? Echo Quick! AI Picks! 🧱🔁🤖
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚀 Just out in European Heart Journal! A novel AI model detects cardiac amyloidosis 🫀 using only a single apical 4-chamber echo clip 🎥🤖 Trained on a multiethnic, multisite cohort 🌍, this deep learning tool achieved AUROC 0.93—outperforming traditional risk scores like TCAS and IWT 📈💥 💡 Smarter screening, faster referrals, fewer missed diagnoses. 🔗 Read more and explore how AI is reshaping heart failure diagnostics👇 #Cardiology #AIinMedicine #Echocardiography #HeartFailure #DigitalHealth #PrecisionMedicine
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🔥 Wakeful Sparks, 🧠 Tired Minds, 🧯 Sleep’s Mito Fix
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠✨ New Insights into Why We Sleep! ✨🛏️ Just read a groundbreaking study in Nature showing that leaky mitochondria in sleep-inducing neurons (dFBNs) drive the pressure to sleep! 😴🧬 Turns out, electron overflow and oxidative stress during wakefulness aren’t just metabolic side effects—they’re biological signals telling the brain it’s time to rest. 🔋➡️💥➡️🛌 Mitochondrial fission decreases sleep, fusion promotes it, and sleep literally resets neuronal metabolism. A must-read for anyone interested in neuroscience, metabolism, or...
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📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Insights on Heart Attack Risk! 🧬❤️ A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥 📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification. 🔍 From base to full model: ➡️ R²: 0.021 → 0.053 ➡️ C-statistic: 0.65 → 0.73 ➡️ PAR: 84.3% Let’s embrace the fusion of clinical +...
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💪🍊 “Flavonoid Fightback: Apigenin Saves Muscle, Not Waistlines”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Research Alert! 💡 Just explored a fascinating preclinical study on apigenin 🧪—a flavonoid found in parsley & chamomile 🌿—that prevents muscle loss in aging, obese rats 🐀💪. 📉 While it didn’t stop weight gain or fat buildup, apigenin boosted muscle mass, reduced fibrosis 🦵, and activated anabolic signaling (p70S6K) 🔁. 💊 Could this be a future nutraceutical for sarcopenic obesity and healthy aging? More clinical research needed—but the signal is strong. 🚦 #Apigenin #Flavonoids #Sarcopenia #Obesity #MuscleHealth #Aging...
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“Shock, Sync, Save 🫀: 2025 AUC Updates Explained”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New in 2025! The ACC/AHA Appropriate Use Criteria for ICDs, CRT, and Pacing just got a major upgrade! 🫀📊 Covering 335 real-world scenarios, this document is your go-to guide for when (and when not) to implant. 💡 What’s 🔥 in the update? ⚡ Leadless & conduction system pacing 🔁 CRT refined for better outcomes 🧠 Smart use in LVADs, post-transplant, & more 👩⚕️ Clinicians: Make device decisions with clarity, confidence, and evidence. 📥 Download our podcast + slides to stay ahead. #Cardiology #ICD #CRT #Pacing #AUC #HeartFailure #EP...
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Dr. RR Baliga’s Philosophical Discourses: : Adi Shankaracharya (India, 788–820 CE) - – Advaita Vedanta Philosopher
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧘♂️📿 Discover the timeless wisdom of Adi Shankaracharya (788–820 CE) — the master of Advaita Vedanta who redefined spirituality with concepts like Atman, Brahman & Sanyasa. His teachings on non-duality still inspire seekers worldwide. 🌍📚 #Philosophy #Vedanta #Spirituality
info_outline🚨 Game-changing breakthroughs in chimaera research! 🧬💓
From beating human hearts grown in pig embryos to human organoids integrating into mouse intestines and brains via amniotic injection—two bold advances are reshaping the future of organ transplantation and regenerative medicine.
But with scientific promise comes ethical complexity. How far should we go in creating human–animal hybrids? What safeguards are needed?
👇 Join the conversation:
Are we building miracles—or crossing lines?
#StemCells #RegenerativeMedicine #Bioethics #ChimaeraResearch #Transplantation #FutureOfMedicine