Sugar Switches: HFpEF’s Hidden Code 🧩🫀🧬
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠💓 Just read a fascinating new study in Cell Metabolism (July 2025): dislocation of hexokinase 1 from mitochondria increases O-GlcNAcylation in endothelial cells — a hidden driver of HFpEF! Reversing this sugar-tagging with OGA overexpression or OGT inhibition restores heart function in mice. Precision metabolism meets cardiology. 🔬❤️🔥 #HFpEF #OGlcNAcylation #EndothelialDysfunction #CardioResearch #MetabolicTherapeutics #CellMetabolism
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Cats, Dogs, and Clarity 🐕🐈💡: The Cognitive Perks of Pet Ownership
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🐾 New Research Alert! 🧠 Owning a dog or cat may do more than warm your heart — it could help preserve your mind! 🐶🐱 A large 18-year study across Europe found that pet owners experienced slower cognitive decline, especially in memory and verbal fluency. 🧪 No boost seen with fish or birds 🐠🐦, but fur friends = brain gains! 🔗 Let’s rethink aging — with tails, not pills. #HealthyAging #PetScience #CognitiveHealth #Longevity #BrainHealth 🧓💡
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🧪🛡️ Stroke Shield: How Tirofiban Tips the Scales
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠✨ New Stroke Breakthrough! The ASSET-IT trial shows that early infusion of tirofiban after thrombolysis significantly boosts recovery in noncardioembolic stroke patients — with 65.9% achieving excellent outcomes at 90 days vs 54.9% with placebo 📈💉 ✅ Improved function ⚠️ Slightly higher bleeding risk 🌏 Study conducted across 38 centers in China 📚 Read the trial in NEJM (July 2025) #Stroke #Tirofiban #Neurology #RCT #PrecisionMedicine #Thrombolysis #CardiovascularResearch
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🧠 Trinity & Truth: The Theological Legacy of Boethius 📜
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
📚✨ Just explored Boethius: The Consolation of Philosophy — a timeless journey from despair to divine reason. Written in prison, this masterpiece blends Roman philosophy with Nicene Christian theology, standing firm against Arianism. 🕊️⚖️ 🎧 Listen now: #Boethius #Theology #FaithAndReason #Podcast 💡🎙️📜
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Exercise Without Exercise? Betaine’s Magic Revealed! 🧘✨🧬”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
💡 New Study Alert! 🏃♂️🧪 Kidney-derived betaine mimics long-term exercise—blocking TBK1, reducing inflammation, and reversing aging markers. This multi-omics human + mouse study uncovers betaine as a precision geroprotector for those who can’t hit the gym. 📈 A leap toward exercise mimetics in aging science! #Geroprotection #PrecisionMedicine #ExerciseScience #Betaine 🧬🧓🔥
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🧪 Reset, Rewind, Rejuvenate: Chemical Reprogramming Against Aging
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬 Rewinding Cellular Time with Chemistry! 🧪 A groundbreaking study just showed that a two-chemical cocktail (2c) — Tranylcypromine + Repsox — can reverse aging markers in human cells and extend C. elegans lifespan by 42%! 🐛💥 Unlike gene-based reprogramming, this method is safer, scalable, and preserves cell identity. Think of it as “Yamanaka lite” — with big implications for aging and longevity science. 🧠💊 #Longevity #Epigenetics #Rejuvenation #Biotech #AgingResearch #Lifespan
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From ABI to Amputation: Navigating PAD with Precision
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚶♂️💔 Just recorded a podcast on Peripheral Artery Disease (PAD) – a silent threat affecting 200M+ people worldwide. We unpack the latest 2024 ACC/AHA guidelines: ✅ When to screen 💊 What therapies work 🦿 How to save limbs & lives Tune in to walk away smarter. 👣🎙️ #PAD #Cardiology #Guidelines #Prevention #LimbSalvage
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Osteoporosis Uncovered: Risk, Resilience, and Recovery 🔍🛡️🔄
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Just finished reviewing the latest JAMA 2025 article on osteoporosis by Morin et al. — a must-read for anyone managing bone health in aging adults! 📉 Despite advances, 70% of fractures occur in those without DXA-defined osteoporosis. 💊 Treatment isn’t just about T-scores — it’s about fracture risk, fall prevention, and smart sequencing of antiresorptive and anabolic therapies. 🏋️♀️ Plus, lifestyle matters: resistance training, calcium, vitamin D, and proactive screening save lives. 📈 Fracture Liaison Services (FLS) boost treatment initiation from 17%...
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🧬 Targeting Aldosterone: A New Shot at Hypertension 🎯💥
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New breakthrough in hypertension care! 💊 The Launch-HTN trial shows lorundrostat — a selective aldosterone synthase inhibitor — significantly lowers systolic BP in patients with uncontrolled or treatment-resistant hypertension. 📉 −16.9 mmHg vs −7.9 mmHg with placebo (P < .001) 🧪 Safe, well-tolerated, and effective across subgroups. A potential game-changer in aldosterone-targeted therapy! 🔄💥 #Hypertension #Cardiology #ClinicalTrials #PrecisionMedicine
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Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Our latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes 🔬💊 We explore: ✅ New diagnostic strategies ✅ Why GLP-1s & SGLT2is are game-changers ✅ How lifestyle change can lead to remission ✅ Individualizing A1C goals in real-world care 🎙️ Episode Title: “Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint” 📈 Essential listening for clinicians, educators, and innovators in endocrine & cardiometabolic care. 👉 Tune in now and share with your network! #Type2Diabetes #CardiometabolicCare #GLP1 #SGLT2...
info_outline🫀 The Heart Ages—But Can We Intervene?
New insights from Nature Reviews Cardiology highlight how endothelial dysfunction, inflammageing, CHIP, and senescence-associated secretory phenotypes (SASP) drive cardiovascular ageing. Promising interventions—from gerotherapeutic diets and exercise to NAD+ boosters, senolytics, and ACBP neutralization—may help delay decline and promote resilience.
💡 Can we target the biology of ageing to extend cardiovascular healthspan, not just lifespan?
👇 Join the conversation: Which intervention holds the most promise—and what are the biggest challenges in translating this to clinical practice?
#Cardiology #Longevity #Geroscience #HeartHealth #Innovation #PrecisionMedicine #HealthyAgeing