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 The AMALFI AF Screening Trial-๐Ÿ“ˆ Atrial Fibrillation Unmasked: A Modest Win for Mailed Monitors show art The AMALFI AF Screening Trial-๐Ÿ“ˆ Atrial Fibrillation Unmasked: A Modest Win for Mailed Monitors

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿ“ข Just read the #AMALFI trial in JAMA ๐Ÿ“ฐ โ€” a landmark remote RCT of AF screening using 14-day ECG patches mailed to older adults at stroke risk ๐Ÿ“ฆ๐Ÿซ€. At 2.5 years, the patch group had a modestly higher AF detection rate (6.8% vs 5.4%, p=0.03) and increased anticoagulation use ๐Ÿ’Š๐Ÿง . Stroke rates were similar โš–๏ธ.   ๐ŸŽฏ Key takeaway: Remote, mail-based AF screening is feasible and nudges diagnosis rates โ€” but will it move the needle on outcomes?   #AFib #StrokePrevention #RemoteMonitoring #ECG #Cardiology #RCT #JAMA #DigitalHealth #Geriatrics ๐Ÿง“๐Ÿ“‰

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๐Ÿ›‘ AFib Gone, OAC Gone? ALONE-AF Challenges Lifelong Therapy show art ๐Ÿ›‘ AFib Gone, OAC Gone? ALONE-AF Challenges Lifelong Therapy

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿšจ New Trial Alert ๐Ÿšจ Can we safely stop anticoagulation after AF ablation? The ALONE-AF Trial ๐Ÿซ€ suggests yesโ€”in selected patients with no AF recurrence, stopping DOACs reduced major bleeding ๐ŸŒŸ without increasing stroke risk ๐Ÿง .   ๐Ÿ“‰ 0.3% vs 2.2% for the composite outcome (P = .02) ๐Ÿ“ Carefully monitored, low-risk patients may benefit most.   ๐Ÿ“ Editorial: Recommends shared decision-making ๐Ÿค & individualized rhythm monitoring. ๐Ÿ“š A potential shift in post-ablation care.   ๐Ÿ”— #AFib #Anticoagulation #EPTrials #CardioTwitter #StrokePrevention #JAMA...

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๐Ÿฆ ๐Ÿ’”Bugged After the Heartbreak?  Does H. pylori Screening After MI Prevent GI Bleeds? show art ๐Ÿฆ ๐Ÿ’”Bugged After the Heartbreak? Does H. pylori Screening After MI Prevent GI Bleeds?

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿšจ New Findings from the HELP-MI Trial! ๐Ÿ‡ธ๐Ÿ‡ช๐Ÿงช Can routine Helicobacter pylori screening during acute myocardial infarction (MI) hospitalization prevent upper gastrointestinal bleeding (UGIB)?   ๐Ÿ’‰ Over 18,000 patients across 35 Swedish hospitals ๐Ÿ“‰ Result: No significant reduction in UGIB overall (RR 0.90; P=0.18) ๐Ÿ” BUT: Clear benefit in patients with anemia (RR 0.44โ€“0.64) and chronic kidney disease (RR 0.75)   ๐Ÿง  Key Takeaway: Routine screening isnโ€™t broadly warrantedโ€”but targeted testing in high-risk AMI patients may be the smarter path forward.   ๐Ÿ“Š...

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๐Ÿงฌ Risk, Recurrence, Relief: Apixabanโ€™s Edge in VTE ๐ŸŒก๏ธ  Emphasizes the risk stratification, recurrence data, and therapeutic benefit show art ๐Ÿงฌ Risk, Recurrence, Relief: Apixabanโ€™s Edge in VTE ๐ŸŒก๏ธ Emphasizes the risk stratification, recurrence data, and therapeutic benefit

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿฉบ New Insights on Apixaban for VTE! ๐Ÿ“ข The HI-PRO trial challenges the old 3-month rule for provoked VTE. ๐Ÿ“‰ Extended low-dose apixaban (2.5 mg BID) reduced recurrent VTE from 10.0% โžก๏ธ 1.3% with minimal major bleeding. ๐ŸŽฏ Editorial in NEJM urges a shift from binary labels (โ€œprovoked vs unprovokedโ€) to a patient-centered, risk-adapted approach. ๐Ÿง  Art meets evidence in the decision to extend anticoagulation. ๐Ÿ’ฌ Letโ€™s rethink how we label, risk-stratify, and treat.   ๐Ÿ“š #VTE #Apixaban #Anticoagulation #NEJM #HI_PRO #Thrombosis #PrecisionMedicine...

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Dr RR Baliga's Philosophical Discourses: Zhu Xi (China, 1130โ€“1200 CE) โ€“ Neo-Confucian Philosopher show art Dr RR Baliga's Philosophical Discourses: Zhu Xi (China, 1130โ€“1200 CE) โ€“ Neo-Confucian Philosopher

Dr. Baliga's 'Podkasts for Curious Docs'

๐ŸŒ Zhu Xi (1130โ€“1200), a master of Neo-Confucianism, reshaped Chinese philosophy with his focus on rationality, self-cultivation & education. His commentaries on the Four Books guided civil service exams for centuries across East Asia. ๐Ÿ“šโœจ   #Leadership #Philosophy #History #Confucianism

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Gait Speed. Grip Strength. Greater Life. ๐Ÿฆต๐Ÿค๐ŸŒŸ A Paradigm Shift in Cardiovascular Recovery for Seniors show art Gait Speed. Grip Strength. Greater Life. ๐Ÿฆต๐Ÿค๐ŸŒŸ A Paradigm Shift in Cardiovascular Recovery for Seniors

Dr. Baliga's 'Podkasts for Curious Docs'

Just read the latest from NEJM? The PIpELINe Trial ๐Ÿ‡ฎ๐Ÿ‡น changes how we approach cardiac rehab in older adults post-MI! ๐Ÿง“โค๏ธ ๐ŸŽฏ A 12-month, multidomain intervention โ€” risk factor control, nutrition ๐Ÿฅ—, and Otago-based exercise ๐Ÿ‘Ÿ โ€” cut CV death/hospitalization from 20.6% โ†’ 12.6% (P=0.01)! ๐Ÿ“‰ Hospitalizations for heart failure dropped 7.1% โ†’ 1.5%. No serious adverse events. And yes โ€” better gait speed, handgrip strength, and quality of life too. This is how we shift from survival โžก๏ธ functional independence in aging populations. ๐Ÿ™Œ ๐Ÿ‘‡ Would you apply this model...

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๐Ÿ’Š Block. Beat. Benefit. The Hidden Strength of ฮฒ-Blockers Post-MI show art ๐Ÿ’Š Block. Beat. Benefit. The Hidden Strength of ฮฒ-Blockers Post-MI

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿšจ New Meta-Analysis Alert! ๐Ÿ’Š๐Ÿซ€ Can ฮฒ-blockers benefit patients post-MI with mildly reduced ejection fraction (LVEF 40โ€“49%)?   ๐Ÿ“Š An individual patient data meta-analysis (REBOOT, BETAMI, DANBLOCK, CAPITAL-RCT) shows a 25% reduction in the composite outcome of death, MI, or HF with ฮฒ-blockers vs. control (HR 0.75; p=0.031) โ€” even in the absence of clinical heart failure.   ๐ŸŒ Consistent across trials and countries. Most benefit seen in patients <75 years. ๐Ÿ“š This could shift guidelines for a large overlooked population.   ๐Ÿ”— Read more in The Lancet (Aug...

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๐Ÿง  REBOOTing Beta-Blockers โ€“ No Gains โš–๏ธ After Modern MI ๐Ÿ’” show art ๐Ÿง  REBOOTing Beta-Blockers โ€“ No Gains โš–๏ธ After Modern MI ๐Ÿ’”

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿšซ๐Ÿ’Š Should We Rethink Beta-Blockers Post-MI? In the landmark REBOOT trial (NEJM, 2025), beta-blockers failed to reduce mortality, reinfarction, or heart failure hospitalizations in post-MI patients with preserved ejection fraction (>40%).   ๐Ÿ’ก A modern, pragmatic trial across 109 centers (Spain + Italy ๐Ÿ‡ช๐Ÿ‡ธ๐Ÿ‡ฎ๐Ÿ‡น) with 8438 patients โ€” shaking the foundation of our long-held post-MI practices. ๐Ÿ‘ฉโ€โš•๏ธ Signals of potential harm in women and STEMI subgroups raise questions, not answers. ๐Ÿ“‰ Should guidelines change? Or should practice just evolve?   #Cardiology...

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Beta Blockers in MI: Old Drug, New Lens, Possible Win ๐Ÿ”๐Ÿ’ฅ๐Ÿฅ show art Beta Blockers in MI: Old Drug, New Lens, Possible Win ๐Ÿ”๐Ÿ’ฅ๐Ÿฅ

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿšจ New NEJM Study Alert! ๐Ÿฉบ๐Ÿ’” Do beta-blockers still help after a heart attack if thereโ€™s no heart failure? ๐Ÿค”   In the BETAMIโ€“DANBLOCK trial (๐Ÿ‡ฉ๐Ÿ‡ฐ+๐Ÿ‡ณ๐Ÿ‡ด, n=5574), beta-blocker therapy in post-MI patients with preserved or mildly reduced LVEF (โ‰ฅ40%) modestly reduced the composite outcome of death or major cardiovascular events ๐Ÿง ๐Ÿ“‰   ๐Ÿ“Œ Primary endpoint: 14.2% (BB) vs. 16.3% (no BB) โ†’ HR 0.85, p=0.03 ๐Ÿ’ก Especially lowered risk of recurrent MI (HR 0.73)   ๐Ÿง  Even in the era of PCI, DAPT & statins, beta-blockers may still bring benefit โ€”...

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๐Ÿงฌ ICDs. Kโบ Boost. Fewer Jolts show art ๐Ÿงฌ ICDs. Kโบ Boost. Fewer Jolts

Dr. Baliga's 'Podkasts for Curious Docs'

๐Ÿ’ฅ New NEJM Trial Alert! A modest 0.3 mmol/L rise in potassium (via MRA, KCl, or diet) significantly reduced arrhythmias, ICD shocks, and hospitalizations in high-risk ICD patients โšก๐Ÿซ€   ๐Ÿ“‰ HR 0.76 for the composite endpoint ๐Ÿ”ข NNT = 12.3 over 3.3 years ๐ŸŒ Safe, scalable, and globally relevant   ๐Ÿ‘‰ Time to rethink โ€œnormalโ€ Kโบ levels in cardiology! #Cardiology #Electrophysiology #NEJM #ICD #Potassium #POTCAST

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More Episodes

๐Ÿงฌ Geroscience is redefining how we think about aging โ€” shifting focus from treating one disease at a time to targeting the biological processes that drive all age-related conditions.

 

From ๐Ÿฝ๏ธ caloric restriction and ๐Ÿ’Š metformin, to ๐Ÿ›ก๏ธ rapalogs and ๐Ÿ” senolytics, the evidence is mounting: intervening in aging biology may improve healthspan, resilience, and quality of life.

 

๐Ÿ“Š The latest JAMA review highlights promising strategies, gaps in clinical evidence, and the urgent need for long-term trials to bring these approaches into mainstream medicine.

 

๐Ÿ’ก Imagine a future where we delay multiple diseases at once, keeping people healthier, longer. Thatโ€™s the promise of geroscience.

 

#Geroscience #HealthyAging #Longevity #PrecisionMedicine #JAMA #Healthspan