Egg Health: The Science of NAD+ Sirtuins - with Dr. Mark Ratner
Release Date: 03/25/2026
Egg Health: The Science of NAD+ Sirtuins - with Dr. Mark Ratner
The Egg Whisperer Show
I am so excited to share this conversation with you. In this episode, I sit down with Dr. Mark Ratner, Chief Science Officer at Theralogix, to talk about a topic I've become incredibly passionate about: NAD+ and its role in egg quality and fertility. If you've been wondering what NAD+ actually is, why your eggs need it, and whether supplementation could make a real difference in your IVF or egg freezing outcomes, this is a must-listen. We get into the science of how NAD+ and sirtuins work together in our cells, why their decline with age is such a big deal for egg health, and the emerging...
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The Egg Whisperer Show
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The Egg Whisperer Show
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The Egg Whisperer Show
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The Most Important Thing to Know Before IVF with guest Dr. Max Ezzati
The Egg Whisperer Show
Preparing for IVF can be an emotional and complex journey, and having the right information beforehand can make all the difference. In this episode, I’m joined by Dr. Max Ezzati, a highly respected reproductive endocrinologist, to discuss the most important thing to know before starting IVF. Dr. Ezzati shares key insights about how patients can optimize their chances of success, the factors that influence embryo quality, and why understanding ovarian reserve is crucial. We also dive into the role of lifestyle factors, genetic screening, and cutting-edge advancements in reproductive...
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I’m 40. Did 5 IVF Cycles, Got Dozens of Eggs, But Not a Single Normal Embryo. What Should I Do Next? (Ask The Egg Whisperer with guest Dr. Steven Palter)
The Egg Whisperer Show
Welcome back to Ask the Egg Whisperer! I'm so excited to have Dr. Steven Palter join me on today's episode. Dr. Palter is the medical and scientific director at Gold Coast IVF in Woodbury, New York, and an internationally recognized leader in fertility treatment. He's also the creator of the PCOS to Pregnancy Protocol - the first comprehensive remote system targeting the root causes of PCOS and the Palter Fertility Method, a personalized approach to diagnosis and care that integrates metabolic health, surgical precision, and emerging reproductive technologies. In this episode, we tackle...
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The Egg Whisperer Show
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The Egg Whisperer Show
If you're one of my patients you'll know which egg quality supplements and sperm quality supplements I want you to be on. I spell it out. I will tell you the doses too. I also make my recommendations as far as which brands to get. But if you're not my patient, I want you to learn from this too. No matter where you live in the world, no matter which brands you have access to, there is a way for you to create your own egg (or sperm) quality regimen too. If you want to hear it all, and get more information about improving your egg quality, tune in to today's episode. Looking for...
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The Egg Whisperer Show
Gina Davis is the founder of Advocate Genetics and a co-founder of EM•POWER with Moxi, an education company dedicated to empowering choice in embryo donation. I’m so honored to have her joining me today on The Egg Whisperer Show podcast! Gina is passionate about impacting the growing field of genetic counseling, and has worked tirelessly to train new genetic counselors, and provide a strong foundation for fertility patients. A former fertility patient herself, she understands the challenges patients face as they try to make sense of the rapid advancements in genetics and fertility...
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When Should You Consider Canceling Your IUI? with guest Dr. Blake Evans
The Egg Whisperer Show
Starting a fertility treatment to then be told that you’re over-responding and can’t move forward is so disappointing for fertility patients. And I love that Dr. Blake Evans has done research on this issue for IUI patients and he’s joining me on The Egg Whisperer Show to share his research findings and provide guidance for us all and to talk about when you should consider canceling your IUI. Looking for clear answers about IVF from a fertility expert? Join Dr. Aimee for The IVF Class, where she explains IVF step by step and answers your questions live during an interactive Zoom...
info_outlineI am so excited to share this conversation with you. In this episode, I sit down with Dr. Mark Ratner, Chief Science Officer at Theralogix, to talk about a topic I've become incredibly passionate about: NAD+ and its role in egg quality and fertility. If you've been wondering what NAD+ actually is, why your eggs need it, and whether supplementation could make a real difference in your IVF or egg freezing outcomes, this is a must-listen.
We get into the science of how NAD+ and sirtuins work together in our cells, why their decline with age is such a big deal for egg health, and the emerging research — from mouse studies to a promising new human trial — suggesting that boosting NAD+ levels could improve fertilization and pregnancy rates. I also share a personal story about a patient whose results completely blew me away after she started NAD+ supplementation on her own. This is the kind of conversation that gets me fired up about the future of fertility medicine.
In this episode, we cover:
- What NAD+ is and how it's present in every cell of your body
- The role of mitochondria in egg development and why eggs require more energy than any other cell
- What sirtuins are and how SIRT1 appears to regulate ovarian reserve
- How the age-related decline in NAD+ and sirtuins creates a "double whammy" for egg quality
- The connection between NAD+, chromosomal abnormalities (aneuploidy), and diminished ovarian reserve
- Key findings from mouse studies and a new human study showing doubled fertilization and clinical pregnancy rates with NAD+ boosting
- How to start supplementing and what to look for
Resources:
- Theralogix website: theralogix.com — Use discount code EGG for ~15% off
- The IVF Class at The Egg Whisperer School
- The Egg Whisperer Show podcast on Spotify and Apple Podcasts
Dr. Aimee's Supplement Stack information
Dr. Aimee Eyvazzadeh is one of America’s most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.