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GLP-1s and Menopause: What Every Woman Over 40 Needs to Know

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Release Date: 08/29/2026

The Estrogen Patch Shortage: What Women Need to Know Before Switching

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

DOWNLOAD YOUR FREE Can't get your usual estrogen patch? Don't panic. You have options! In this free guide, hormone specialist Karen Martel breaks down the different estrogen delivery methods, including patches, creams, gels, oils, and injections. Learn how they compare, understand approximate dosing equivalents, and discover what to ask your doctor before making a switch. Plus, get practical tips for navigating the estrogen shortage so you can stay on track with your hormone therapy and avoid unnecessary disruptions. Imagine finally getting your HRT dialed in, feeling good again,...

Quick Hits: The Protein Mistake That Could Be Costing You Muscle in Midlife with Angelo Keely

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. We talk constantly about eating more protein in midlife. But here is the question we do not ask nearly enough: Is your body actually getting what it needs from that protein? Because there is a big difference between eating protein, digesting protein, getting enough of the right amino acids, and actually giving your body what it needs to maintain...

Menopause and Heart Disease: What Women Are Still Not Being Told with Dr. Suzanne Steinbaum

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Most women enter perimenopause thinking about hot flashes, weight gain, sleep, brain fog, and hormones. Very few are told that this may also be one of the most important cardiovascular windows of their lives. And that is a problem. Heart disease remains the number one killer of women, yet women are still being underdiagnosed, dismissed, and evaluated using systems that were largely built around male cardiovascular disease. In this episode, I sit down with preventative cardiologist Dr. Suzanne Steinbaum to talk about what women actually need to understand about their hearts in perimenopause and...

Quick Hits: Empower Your Physique: Breaking Misconceptions for Women Over 40 with Philip Pape

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. This week we're exploring the intricacies of hormonal health and nutrition for women over 40, including the delicate balance between diet, exercise, and hormones. Joining us is nutrition expert Philip Pape, and together we debunk diet myths and provide personalized strategies to maintain energy, muscle mass, and metabolic health. We also discuss...

Why Do My Joints Suddenly Hurt in Perimenopause?

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

DOWNLOAD OUR FREE GUIDE "IS YOUR HRT OPTIMIZED!" Yesterday morning, I sat up in bed and somehow threw my neck out. That was it. I did not fall. I did not lift anything heavy. I did not have some dramatic injury. I literally sat up. And if you are somewhere in your 40s or 50s, there is a very good chance you have your own version of this story. Your shoulder suddenly stops moving properly. Your back goes out doing something completely ordinary. Your knees start aching. Your Achilles is angry. Your elbow hurts for no apparent reason. Workouts you used to recover from easily suddenly leave...

Quick Hits: Estrogen Has Been Vindicated! Estrogen HRT & Its Crucial Role in Breast Cancer Prevention with Dr. Lindsey Berkson

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

This is Quick Hits, where I pull the best takeaways from past podcast episodes and bring them to you in a shorter format. If today’s clip resonates with you, be sure to check out the full episode linked below. Download in iTunes or on your favorite podcast platforms. Dr. Devaki Lindsey Berkson is a thought leader in functional medicine, with an emphasis on hormones, nutrition, digestion, and intimacy. Berkson was a distinguished hormone scholar at a world-renowned estrogen think tank at Tulane University because she wrote one of the first breakthrough books on endocrine disruption)....

The Midlife Peptide Guide: Energy, Muscle, Recovery, Skin, Sleep & Libido with Dr. Jeff Gross

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Peptides are everywhere right now. They are being talked about for fat loss, muscle, recovery, brain health, skin, longevity, inflammation, mitochondrial function, injury repair, and just about every other problem women run into in midlife. But which peptides actually make sense? Which ones have useful evidence or clinical experience behind them? Which ones are still early? And where do peptides fit when a woman is already dealing with changing hormones, declining muscle, stubborn body composition changes, poor sleep, low energy, and slower recovery? In this episode, I sit down with Dr. Jeff...

Quick Hits: The Sun Deficiency Epidemic: Could Sunlight Be the Missing Link in Modern Health W/ Gerardo Gutierrez

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits, where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most popular conversations. Want the full episode? You’ll find the link below. Are we getting enough of the right kind of light? In this Quick Hits episode, I pull out the biggest takeaways from my conversation with Gerardo “Guti” Gutierrez on sunlight, UVB, vitamin D, red light therapy, infrared light, circadian rhythm, and hormone health. We break down why sunlight is about far more than vitamin D, how UVA and UVB affect the body differently,...

What Happened When I Stopped Drinking: Hormones, Weight, Stress, and Breaking the Cycle

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

This may be one of those episodes you are tempted to skip because nobody really wants to hear that their nightly glass of wine could be working against them. But this is not a lecture about why you should never drink again. In this episode, I’m having a very honest conversation about alcohol, especially for women in their 40s, 50s, and beyond. We talk about how drinking may affect sleep, cortisol, cravings, estrogen metabolism, liver health, insulin sensitivity, weight loss, and the way your body handles stress as you move through perimenopause and menopause. But this conversation goes much...

Quick Hits: Breathwork for Women: Igniting Inner Empowerment with Kyla Erlandson

The Hormone Solution | Menopause, Perimenopause, & Women's Midlife Health

Welcome to Quick Hits — where we bring you the most impactful moments from past episodes in under 15 minutes. Today’s clip comes from one of our most replayed conversations. If you want the full episode, check the link in the description below. Breathwork has been used for thousands of years across cultures as a powerful tool for healing, emotional release, self-discovery, and spiritual connection. Yet most of us move through our days barely thinking about our breath, let alone using it intentionally. In this episode, we explore how breathwork can help you reconnect with yourself,...

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You cannot open your phone anymore without hearing about Ozempic, Wegovy, Mounjaro, Zepbound, retatrutide, and before-and-after transformations. One person says GLP-1s are the greatest thing ever. Another says they are going to destroy your health.

As usual, the truth is somewhere in the middle.

In this episode, I break down GLP-1s specifically through the lens of perimenopause and menopause, because midlife women are dealing with a completely different metabolic landscape. Estrogen is changing. Muscle is easier to lose. Insulin sensitivity may be shifting. Sleep is falling apart. Belly fat is showing up where it never used to. And simply telling a woman to eat less and exercise more is not a strategy.

We talk about where GLP-1s can be incredibly useful, why HRT and GLP-1s are not interchangeable, and why protecting muscle has to be one of your top priorities if you are using these medications. I also get into dosing, microdosing, appetite suppression, thyroid and hormone optimization, realistic weight-loss rates, and why the goal should never be to get as skinny as possible as fast as possible.

The goal is to lose fat while preserving muscle, supporting hormones, improving metabolic health, and having an actual plan for what happens after the weight comes off.

In this episode, we cover:

Why menopause changes fat distribution and increases abdominal fat for many women
How declining estrogen, muscle loss, sleep, and insulin resistance affect midlife weight
How GLP-1 medications work beyond simple appetite suppression
Why GLP-1s are not “cheating”
Why GLP-1 therapy does not replace HRT
Whether HRT and GLP-1s can be used together
Why muscle loss is one of the biggest concerns with GLP-1 use
Why protein and resistance training matter so much
Why having no appetite does not mean your dose is perfect
Microdosing versus standard GLP-1 dosing
Why increasing your dose too quickly can backfire
What a realistic rate of weight loss can look like
The importance of thyroid and hormone optimization when weight loss stalls
Why maintenance needs to be part of the plan from day one

Who This Episode Is For

This episode is for women in perimenopause and menopause who are considering a GLP-1, already taking one, or wondering whether these medications could help with stubborn midlife weight gain.

It is especially for women who want to lose fat without sacrificing muscle, energy, hormones, bone health, or long-term metabolic health.

If you are confused by the microdosing hype, worried about muscle loss, unsure whether you should do HRT or a GLP-1 first, or wondering why your weight loss has stalled even though you are taking medication, this episode is for you.

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