127: The Impact of Depression on Longevity and Healthspan
Release Date: 03/17/2025
153: T Cells, Aging, and Extreme Life Extension
Longevity Roadmap
Dr. Derya Unutmaz joins Dr. Buck Joffrey to discuss the critical role of T cells in the immune system, their changes with aging, and the implications for chronic diseases. He emphasizes the importance of thymus regeneration and the microbiome's influence on health. The discussion also covers advancements in engineering immune cells for cancer treatment and the potential of AI in revolutionizing aging research and drug discovery. Unutmaz expresses optimism about the future of aging research, highlighting the need for a shift in how aging is perceived in the medical community. Learn more about...
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152: The Role of Vitamin A in Brain Health
Longevity Roadmap
In this episode, Professor Peter McCaffery joins Dr. Buck Joffrey to discuss the multifaceted role of Vitamin A in brain health, particularly its function as a signaling molecule that influences neuroplasticity and cognitive functions. He elaborates on the challenges of Vitamin A supplementation, especially in aging populations, and the implications of retinoic acid signaling in neurodegenerative diseases like Alzheimer's. The discussion also touches on the importance of skin health in the context of systemic aging and the potential for targeted therapies to enhance Vitamin A signaling without...
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151: Does Astaxanthin Increase Longevity?
Longevity Roadmap
In this episode, Dave Watumull joins Dr. Buck Joffrey to discuss the benefits and mechanisms of astaxanthin, a powerful antioxidant and anti-inflammatory compound. He explains its role in longevity, particularly through the Interventions Testing Program (ITP), where astaxanthin was shown to extend lifespan in male mice by 12%. The discussion also covers the safety profile, bioavailability, and clinical studies demonstrating cardiovascular benefits. Gender differences in efficacy are explored, along with practical advice on dosage and where to find astaxanthin products. Learn more about AX3:...
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150: The Microbiome’s Role in Aging and Healthspan
Longevity Roadmap
Dr. Sean Gibbons joins Dr. Buck Joffrey to discuss the complexities of the gut microbiome, its evolution, and its significant role in health and longevity. He explains how our microbiome is established at birth, how it changes throughout life, and the impact of diet and lifestyle on its composition. The discussion also covers the challenges of modifying the microbiome, the potential of precision nutrition, and the emerging field of fecal transplants. Dr. Gibbons emphasizes the importance of butyrate, a beneficial short-chain fatty acid produced by gut bacteria, and the future of microbiome...
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149: How Dental Health Impacts Longevity
Longevity Roadmap
Dr. Ellie Phillips, DDS, joins Dr. Buck Joffrey to explain how oral pathogens contribute to chronic inflammation and conditions such as cardiovascular disease, Alzheimer’s, and adverse pregnancy outcomes. She shares the science behind xylitol, saliva-driven remineralization, and practical strategies for supporting a healthy oral microbiome to reduce systemic risk. Learn more about Dr. Ellie Phillips: https://drellie.com/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: Book a FREE longevity coaching consultation with Dr. Buck Joffrey:
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148: Dr. Kevin J. Tracey - Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan
Longevity Roadmap
Dr. Kevin J. Tracey, neurosurgeon, immunologist, and pioneer in bioelectronic medicine, discusses the discovery of the inflammatory reflex and how vagus nerve stimulation can precisely regulate immune activity without immunosuppression. He explains its clinical application in rheumatoid arthritis, potential use in Crohn’s disease, multiple sclerosis, and metabolic disorders, and its implications for extending healthspan. Watch the full episode to explore how targeting neural circuits could redefine the treatment of inflammation. Get Dr. Kevin J. Tracey's book, The Great Nerve: Learn more...
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147: The Wrong Vitamin E Supplement Can Hurt You
Longevity Roadmap
In this conversation, Dr. Barrie Tan joins Dr. Buck Joffrey to discuss the significance of tocotrienols—a lesser-known form of vitamin E—and their potential role in preventing chronic disease and promoting healthy aging. Dr. Tan explains the differences between tocopherols and tocotrienols, the role of vitamin E in human health, and highlights the annatto plant as a key natural source of tocotrienols. The discussion also touches on clinical trials, the anti-inflammatory effects of tocotrienols, and how they work in synergy with other supplements. Learn more about Dr. Barrie Tan:...
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146: AMA President Dr. Bobby Mukkamala - Healthspan-Centric Medical Care in America
Longevity Roadmap
Joining Dr. Buck Joffrey this week, Dr. Bobby Mukkamala shares his journey from aspiring cardiothoracic surgeon to becoming the president of the American Medical Association. He discusses his personal health challenges, including a brain tumor diagnosis, and how it has shaped his perspective on healthcare. The conversation delves into the importance of preventative medicine, the impact of the Flint water crisis, and the role of the AMA in shaping the future of healthcare, particularly in the realm of longevity and AI. Dr. Mukkamala emphasizes the need for a shift from reactive to proactive...
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145: Why Some Animals Live Longer Than Others with Dr. Steven Austad
Longevity Roadmap
In this conversation, Dr. Buck Joffrey and Dr. Steven Austad discusse the biology of aging, the evolutionary aspects of longevity, and the potential for genetic technologies to extend human health span. Dr. Austad emphasizes the complexity of aging, the importance of glucose control, and the need for further research into species that exhibit remarkable longevity. The discussion also touches on the challenges and ethical considerations of manipulating human genetics for longevity. Learn more about Dr. Steven Austad: https://www.stevenaustad.com/ - Download Dr. Buck Joffrey's FREE ebook, Living...
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144: Why the Brain is Especially Vulnerable to Aging
Longevity Roadmap
In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain’s heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions....
info_outlineSuicide rates are rising—and the impact on longevity is profound. In this eye-opening episode of Longevity Roadmap, Dr. Peter Franz dives deep into the intersection of mental health, suicide prevention, and lifespan. He explores why nearly 50% of Americans experience depression, how loneliness accelerates suicide risk, and why digital interventions offer new hope. We also unpack the demographics most at risk, the physiology behind depression and suicidal thoughts, and the critical role of reducing stigma around mental health. Dr. Franz offers practical insights for recognizing warning signs, improving treatment access, and understanding future strategies to personalize suicide prevention.
Learn more about Dr. Peter Franz:
https://www.yu.edu/faculty/pages/franz-peter