Challenges of Chromatographic Analysis for New Modalities
Release Date: 05/12/2025
Peak Integration in Chromatography – Practical Tips for Smarter Analysis
Chromatography Life
In this episode, Neil Lander sits down with renowned analytical chemist Bob McDowall to explore the complexities of chromatographic peak integration. With over 50 years of experience, Bob shares insights into data integrity, regulatory compliance, and the evolving role of manual vs. automated integration. The conversation dives into real-world examples, AI’s potential role in chromatography, and best practices for developing scientifically sound SOPs.
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Rediscovering Slalom Chromatography – A Forgotten Technique Reimagined
Chromatography Life
In our latest episode of Chromatography Life podcast, we explore a fascinating and nearly forgotten separation technique—slalom chromatography—with Dr. Fabrice Gritti, Consulting Scientist at Waters Corporation. Dr. Gritti brings decades of expertise in separation science and shares how this 1980s-era method is being revived to meet today’s challenges in DNA and RNA analysis. Dr. Gritti also shares his vision for the future of chromatography, including AI-driven column design and 3D-printed stationary phases.
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Adopting AQbD Principles to Method Development
Chromatography Life
In Episode 9 of Chromatography Life, we sit down with Richard Verseput, a pioneer in QbD-driven analytical development, to explore how automation, risk assessment, and smart experimental design are revolutionizing chromatography. From cutting-edge tools like Fusion QbD to real-world strategies for building robust, adaptable methods, this episode is packed with insights that can transform your lab’s efficiency and precision. Whether you're optimizing LC-MS workflows or navigating regulatory expectations, this is a must-listen for every analytical scientist.
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Equilibration Injections Under the Microscope
Chromatography Life
Join host Neil Lander as he sits down with Peter Baker, President of Live Oak Quality Assurance and former FDA Investigator of the Year, to explore the complexities of equilibration injections in regulated laboratories. Peter shares his global regulatory experience, offering insights into data integrity, risk management, and how to avoid common compliance pitfalls. This episode is a must-listen for those navigating regulatory expectations in analytical labs.
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Tools to Support Enhanced Method Development
Chromatography Life
Join host Neil Lander as he sits down with Margaret Maziarz, Principal Scientist at Waters Corporation, to discuss the latest tools and strategic approaches to optimizing method development. Margaret guides us through the advantages to various types of instrumentation, the importance of selecting the right column chemistry, and the powerful capabilities of Empower software. She highlights the critical role of monitoring method performance over time and the challenges of transferring methods between LC systems. For those looking for a quick dose of method development expertise, this episode is...
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Advancements and Challenges in GLP-1 Peptide Drugs
Chromatography Life
This episode of Chromatography Life takes a closer look at the evolving landscape of synthetic peptide drugs - one of the most compelling frontiers in biopharmaceutical analysis. Joining us is Matt Lauber, Senior Director at Waters and a recognized authority in bioanalysis and drug product characterization, who shares both his personal and professional journey, along with his insights into the science shaping today’s peptide therapeutics. We discuss the growing significance of GLP-1 peptide drugs, the analytical hurdles they present, and the chromatographic techniques that help ensure...
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Challenges of Chromatographic Analysis for New Modalities
Chromatography Life
Join host Neil Lander on Chromatography Life as he interviews, Arnaud Delobel, R&D and Innovation Director at Quality Assistance. In this episode, Arnaud discusses chromatographic analysis for new modalities, with adeno-associated viruses (AAVs) in the spotlight. He discusses the complexities of analyzing these large biomolecules and the innovative techniques being developed to improve their characterization. Tune in to glimpse the future of chromatography and learn about the incredible advancements that are helping to tackle some of the toughest human health challenges.
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Automating Dissolution in the Laboratory
Chromatography Life
Join host Neil Lander on Chromatography Life as he interviews Ben Calvopina, Application Scientist and expert in dissolution testing at SOTAX. Ben shares his journey from service engineering to leading automation projects, highlighting the impact of automation on efficiency and accuracy in pharmaceutical quality control. The episode explores the practical aspects of automating dissolution methods and the importance of validation to ensure reliable results. Tune in to this episode to learn about the latest trends and future directions in chromatography and dissolution.
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The Evolution of UPLC Columns
Chromatography Life
In this episode of the Chromatography Life podcast, our host Neil Lander sits down with Tom Walter, a corporate fellow at Waters, to explore the fascinating journey of UPLC column evolution. Tom, a seasoned expert with numerous patents and innovations under his belt, shares his experiences and insights from his extensive career in chromatography. From the early days of large particle columns to the cutting-edge small particle technology of today, Tom discusses the challenges, breakthroughs, and environmental impacts of UPLC advancements. Join us for an engaging conversation that sheds light on...
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Validating Chromatographic Methods: Challenges, Tools, and Optimization
Chromatography Life
Join host Neil Lander as he welcomes Katy Rhynard, Associate Director of Laboratory Informatics at Gilead Sciences. In this episode, Katy discusses the intricacies of validating chromatographic methods, including guidelines and regulatory requirements, key success metrics, documentation, techniques, and tools. Katy details the pervasive challenges in method validation, and how to effectively leverage tools in Empower to optimize stages throughout the process. Katy guides us through the steps to upgrade our lab’s method validation processes and shares how Empower’s Method Validation Manager...
info_outlineJoin host Neil Lander on Chromatography Life as he interviews, Arnaud Delobel, R&D and Innovation Director at Quality Assistance. In this episode, Arnaud discusses chromatographic analysis for new modalities, with adeno-associated viruses (AAVs) in the spotlight. He discusses the complexities of analyzing these large biomolecules and the innovative techniques being developed to improve their characterization. Tune in to glimpse the future of chromatography and learn about the incredible advancements that are helping to tackle some of the toughest human health challenges.