Today Dr. Seema Mattoo, Associate Professor of Biological Sciences at Purdue University, joins the #QualityQuorum to discuss the fascinating molecular genetics of the bacterium Bordetella pertussis, which can cause the human disease whooping cough.
Host: Mark O. Martin
Guest: Seema Mattoo
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Links for this episode
- Here is a link to Tiffany Ard’s fine science related art.
- CDC information regarding Whooping Cough also called pertussis.
- An overview of the causative agent of whooping cough, Bordetella pertussis.
- A video about pertussis and its symptoms and treatment.
- More detail about B. pertussis and close relatives.
- Recent outbreaks of pertussis.
- An overview of vaccine development and its history for B. pertussis.
- An article about vaccine hesitancy and the return of childhood diseases like pertussis.
- Information on “whole cell” versus “acellular” vaccines.
- An article discussed today, demonstrating that the same molecule (a fragment of bacterial cell wall peptidoglycan) can be a factor for disease in humans, and facilitate symbiotic light organ development in the Hawai’ian Bobtail Squid
- More information of B. pertussis’ trachael cytotoxin, or TCT.
- An overview of bacterial effectors interacting with our physiology in general.
- The concept of virulence factors.
- IgA versus IgG responses to infections.
- An overview of Type III Secretion Systems.
- An overview of sigma factors in bacteria.
- ECFs as sigma factors.
- Partner-switching studies.
- Fic genes.
- An overview of post translational modification.
- An essay on Theodosius Dobzhansky and his famous maxim.
- Protein misfolding and disease.
- The role of mentorship in science.
- The Hypothesis Fund and its aims.
- An article by Dr. Mattoo and colleagues discussed today about partner switching and Type III Secretion Systems.
- An article by Dr. Mattoo and colleagues discussed today about Fic proteins and adenylation.
- An article by Dr. Mattoo and colleagues discussed today about Fic proteins, post translational modification, and Parkinson’s Disease.
- An article by Dr. Mattoo and colleagues discussed today about AMPylation, Fic proteins, and sensing misfolding in the endoplasmic reticulum.
- Dr. Mattoo’s faculty website.
- The fascinating laboratory website of Dr. Mattoo and colleagues.
Intro music is by Reber Clark
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