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Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA’s upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn

DiabetesBio

Release Date: 05/01/2025

Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus “Sweet Talk” with Sir Stephen O’Rahilly show art Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus “Sweet Talk” with Sir Stephen O’Rahilly

DiabetesBio

Welcome to the February 2026 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2026 issue of Diabetes. 6:10 To discuss this issue’s Paper of the Month, our hosts are joined by authors , PhD and , MD, PhD, both of Vanderbilt University. Their article, “B Lymphocytes Impede Tregs to Erode Islet Tolerance in Type 1 Diabetes,” is available for free at ....

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Masaya Oshima on the effects of killing human β-cells by CD8+ T cells and “Sweet Talk” with Sarah Stanely on the neural regulation of blood glucose in acute stress show art Masaya Oshima on the effects of killing human β-cells by CD8+ T cells and “Sweet Talk” with Sarah Stanely on the neural regulation of blood glucose in acute stress

DiabetesBio

Welcome to the January 2026 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2026 issue of Diabetes. 17:40 After sharing their predictions for the new year, our hosts are joined by , PhD, a contract researcher at Institut Cochin in Paris, France. He is the lead author on the January Paper of the Month, “Killing of Human β-Cells by CD8+ T Cells Triggers Inflammatory...

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Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic “Sweet Talk” with Banks, Holman, & Lan show art Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic “Sweet Talk” with Banks, Holman, & Lan

DiabetesBio

Welcome to the December 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2025 issue of Diabetes. 13:10 After discussing their favorite interviews of the past two years, our hosts are joined by , PhD, a professor in the Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado Anschutz Medical Campus. He is the corresponding author of “Combined...

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Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus “Sweet Talk” with Banting Medal recipient Jens Juul Holst show art Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus “Sweet Talk” with Banting Medal recipient Jens Juul Holst

DiabetesBio

Welcome to the November 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2025 issue of Diabetes. 6:00 In the first segment, our hosts are joined by , MS and , MD, MPH, FAHA, both of the Department of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina. Their paper, “Diabetes Genetic Clusters and Clinical Outcomes in...

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Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, “Sweet Talk” on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity show art Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, “Sweet Talk” on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity

DiabetesBio

Welcome to the October 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2025 issue of Diabetes. 5:50 In the first segment, our hosts are joined by , PhD, a Chain Florey TTI Fellow in the MRC Laboratory of Medical Sciences at Imperial College London. She is the first author of the article “Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis,” available...

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Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & “Sweet Talk” with Pathway to Stop Diabetes Award recipient Alexander Nectow show art Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & “Sweet Talk” with Pathway to Stop Diabetes Award recipient Alexander Nectow

DiabetesBio

Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes. 5:25 In the first segment, our hosts are joined by , PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of...

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Special Edition: Highlights from the ADA’s 2025 Scientific Sessions show art Special Edition: Highlights from the ADA’s 2025 Scientific Sessions

DiabetesBio

   In this special crossover episode, recorded live at the American Diabetes Association’s 85th Scientific Sessions in Chicago, the hosts of ADA’s professional podcasts—Diabetes Core Update, Diabetes Care “On Air”, and DiabetesBio—come together to discuss key highlights and groundbreaking research presented at the 2025 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year’s findings mean for clinical...

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A special extended “Sweet Talk” episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD. show art A special extended “Sweet Talk” episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD.

DiabetesBio

Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month’s episode, a special extended edition of “Sweet Talk,” exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by , OC, MD, FRCPC, FRSC, FRS, recipient...

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Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, “Sweet Talk” with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan show art Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, “Sweet Talk” with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan

DiabetesBio

Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July’s Paper of the Month, titled “Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis.” They’re joined by corresponding authors Dr. , professor in the Department...

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Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura show art Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura

DiabetesBio

Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and “Sweet Talk” with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of...

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More Episodes

Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes. 

6:25 In the first interview segment, our hosts discuss May’s Paper of the Month, titled “β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation.” They’re joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729

 25:30 It’s a special two-part edition of “Sweet Talk.” In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They’re joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year’s Scientific Sessions programming committee. 

48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association’s Banting Medal for Scientific Achievement, and he discusses his landmark paper, “Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function,” available for free at doi.org/10.2337/diab.42.11.1663.

 They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection.

 To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!