DiabetesBio

DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.

Wilson & Moore on B Lymphocytes and eroding islet tolerance in type 1 diabetes, Mittendorfer on the effects of marked weight loss on postprandial glucose disposal in type 2 diabetes, plus “Sweet Talk” with Sir Stephen O’Rahilly 02/06/2026

Masaya Oshima on the effects of killing human β-cells by CD8+ T cells and “Sweet Talk” with Sarah Stanely on the neural regulation of blood glucose in acute stress 01/06/2026

Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic “Sweet Talk” with Banks, Holman, & Lan Welcome to the December 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2025 issue of Diabetes. 13:10 After discussing their favorite interviews of the past two years, our hosts are joined by , PhD, a professor in the Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado Anschutz Medical Campus. He is the corresponding author of “Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition,” a featured article in this month’s issue. The article is available for free at . 35:25 To discuss the latest Paper of the Month, our hosts are joined by authors , PhD, postdoctoral researcher at CU Anschutz, , PhD, a postdoctoral fellow at the University of California San Francisco, , PhD, Assistant Professor in the Department of Biochemistry and Molecular Genetics at the CU Anschutz, and , PhD, Associate Professor in the Department of Pharmacology and Therapeutics at the University of Florida. Their article, “Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells,” is available for free at . 1:00:50 In the latest edition of “Sweet Talk,” Kevin and Kirk explore how new technologies shape the ways we assess metabolism. They are joined by , PhD, Director of the Energy Balance core facility at Beth Israel Deaconess Medical Center (BIDMC) at Harvard Medical School, , PhD, Technical Director of the at the University of Pennsylvania, and , PhD, Metabolic Pathophysiology Core Managing Director at Vanderbilt University Medical Center. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/39295600

Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus “Sweet Talk” with Banting Medal recipient Jens Juul Holst 11/07/2025

Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, “Sweet Talk” on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity 10/08/2025

Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & “Sweet Talk” with Pathway to Stop Diabetes Award recipient Alexander Nectow Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes. 5:25 In the first segment, our hosts are joined by , PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of “GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice,” available for free at . 27:30 Next, Darleen and Kirk speak with , MD, Professor of Medicine in the Division of Endocrinology at the Ohio State University College of Medicine. She is a corresponding author on this month’s Paper of the Month, “The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism,” available for free at . 46:20 Lastly, in this month’s edition of “Sweet Talk,” Kevin and Darleen are joined by , MD, PhD. A recipient of the American Diabetes Association’s Pathway to Stop Diabetes Award, Dr. Nectow lab at Columbia University studies the dorsal raphe nucleus (DRN) and its relation to metabolism. His article, "The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes,” is available for free at . To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/38144705

Special Edition: Highlights from the ADA’s 2025 Scientific Sessions 08/15/2025

A special extended “Sweet Talk” episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD. Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month’s episode, a special extended edition of “Sweet Talk,” exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by , OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association’s (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with , PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, “Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies,” available for free at . 42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, “A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity,” available for free at , and a counterpoint article titled “GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale,” also available for free at . And don’t forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts! To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/37640070

Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, “Sweet Talk” with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July’s Paper of the Month, titled “Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis.” They’re joined by corresponding authors Dr. , professor in the Department of Molecular Medicine and Metabolism, the Research Institute of Environmental Medicine at Nagoya University in Nagoya, Japan, and , a lecturer in the same department. This article is available for free at . 22:25 Our hosts speak with , PhD, Professor of Population and Public Health Sciences in the Department of Population and Public Health Sciences at the University of Southern California Keck School of Medicine. His paper, “Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver,” is available at . 46:50 In this month’s edition of “Sweet Talk,” our hosts are joined by , MD, recipient of the American Diabetes Association’s Albert Renold Distinguished Career Award, to discuss her work uncovering key molecular mechanisms contributing to type two diabetes and the role of adipose tissue in regulating systemic insulin sensitivity. Dr. Kahn is the George Richards Minot Professor of Medicine at Harvard Medical School and Vice Chair for Research Strategy at Beth Israel Deaconess Medical Center in Boston. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/37448180

Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and “Sweet Talk” with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes. 4:40 In the first interview segment, our hosts discuss June’s Paper of the Month, titled “Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk.” They’re joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at . 17:25 Our hosts speak with , PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University’s Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, “The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans,” available for free at . 33:55 In this month’s edition of “Sweet Talk,” our hosts are joined by , PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA’s 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/36850835

Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA’s upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes. 6:25 In the first interview segment, our hosts discuss May’s Paper of the Month, titled “β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation.” They’re joined by corresponding author , MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at 25:30 It’s a special two-part edition of “Sweet Talk.” In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They’re joined by , American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year’s Scientific Sessions programming committee. 48:10 In part two, our hosts speak with , MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association’s Banting Medal for Scientific Achievement, and he discusses his landmark paper, “Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function,” available for free at . They also discuss the of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at . To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/36394165

Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes. 6:30 In the first interview segment, our hosts discuss an article titled “Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice.” They’re joined by corresponding author , BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at . 25:20 Our hosts discuss the latest Paper of the Month, entitled “An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target.” They’re joined by corresponding author , MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at . 38:55 In the special edition of “Sweet Talk,” our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They’re joined by the people who knew him best: , PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, , PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and , PhD, professor at UT Southwestern Medical Center in Dallas, Texas. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/35996755

Anne Gresch & Martina Düfer on resolving spatiotemporal electrical signaling within the islet, Delnaz Roshandel on the genetics of C-peptide and age, and a Sweet Talk history lesson with Jeffrey Flier & Christopher Newgard Welcome to the March 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2025 issue of Diabetes. 3:20 In the first interview segment, our hosts discuss the Paper of the Month, “Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays.” They’re joined by , PhD, a postdoctoral fellow at the University of Colorado’s Anschutz Medical Campus, and Prof. Dr. , from the Department of Pharmacology at the University of Munster Pharmaceutical and Medicinal Chemistry in Munster, Germany. This article is available for free at . 22:40 Our hosts discuss an article from the February issue of Diabetes, entitled “Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes.” They’re joined by lead author , PhD, Senior Research Associate, and Andrew Paterson, MD, both of the Genetics and Genome Biology Program at the Hospital for Sick Children in Toronto, Canada. This article is available for free at . 36:20 In the special edition of “Sweet Talk,” our hosts welcome , MD, former Dean of Harvard Medical School and past recipient of the ADA’s Banting Medal, as well as , PhD, leader in pancreatic islet biology and metabolic disease at Duke University School of Medicine and previous recipient of the ADA’s Outstanding Scientific Achievement Award. They discuss an article by Diabetes editor-in-chief, David A. D’Alessio, on the historic development of the insulin radioimmunoassay, available for free at . To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/35544820

Francis C. Lynn on tracking insulin- and glucagon-expressing cells, David C. Wraith & Michael J. Price on antigen-specific immunotherapy for T1D, and Sweet Talk with Bret H. Goodpaster 02/10/2025

Philipp Scherer & Joel Elmquist on the interplay between the brain and adipose tissue and Jonathan Flak on the brain’s role in glucose regulation, energy balance, and bodyweight control. 01/09/2025

Philipp Scherer & Joel Elmquist on the interplay between the brain and adipose tissue and Jonathan Flak on the brain’s role in glucose regulation, energy balance, and bodyweight control. Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes. 2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature. 3:35 In part one of this special Sweet Talk segment, our hosts are joined by , PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and , DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA’s Outstanding Scientific Achievement Award, and Scherer recently received the ADA’s Banting Medal. They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases. 33:00 In part two, our hosts speak with , PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA’s Pathway to Stop Diabetes Award. He discusses his work on the brain’s role in glucose regulation, energy balance, and bodyweight control. His , “Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes,” can be found in the of Diabetes. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/34788340

Stilgenbauer & Sadagurski on the link between airborne pollutants and metabolic disease, Petersen on the effect of weight loss on skeletal muscle bioactive lipids, and Page & Alves on the neurodevelopmental pathways to obesity and type 2 diabetes. Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes. 0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include: Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia 6:15 Darleen is joined by of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as , associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University. They discuss their article “Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling.” This article is available for free at 33:45 Kirk and Kevin dive into the December issue’s Paper of the Month, “Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes.” They’re joined by lead author , an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at . 47:20 Finally, this month’s edition of Sweet Talk focuses on work funded by the American Diabetes Association’s Pathway to Stop Diabetes initiative. , Associate Professor of Medicine at the University of Southern California’s Keck School of Medicine, and , a postdoctoral research fellow with Page, stop by to discuss Page’s study, “Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes.” The article is available at To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/34307765

Maxwell and Grillo on the link between feeding behaviors and leptin activation of dorsal raphe neurons, Fruttiger on microvascular damage and neurodegeneration in early diabetic retinopathy, and Yeo on the genetics of metabolic health. Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes. 3:45 After a quick rundown of our hosts' Halloween plans, this month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to , create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and , a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article “Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior.” This article is available for free at . 27:05 Our hosts discuss the November issue’s Paper of the Month, “Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy.” They’re joined by senior author, , Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at . 50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month’s Sweet Talk segment features , a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/33695662

Grøndahl on glucagon clearance decrease in kidney disease despite preservation in liver cirrhosis, Barra and Russ on cryopreservation of stem cell–derived β-like cells, Sunilkumar and Dennis on targeting REDD1 to combat diabetes complications, & more! Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:05 This month’s episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to , create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 5:15 Darleen and Kirk speak with , faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, “Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis.” This article is available for free at . 19:05 Our hosts discuss a featured article entitled “Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function.” They’re joined by the study’s lead author, , and corresponding author—as well as Barra’s mentor—. This study is available at . 35:00 Finally, just in time for National Vision Awareness Month, a Sweet Talk segment first: a discussion on the important topic of diabetic retinopathy. and discuss their Perspectives article, “REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes,” funded by the ADA Pathway to Stop Diabetes Initiator Award, which was given to Dr. Dennis in 2014. This article is freely accessible at . To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/33411132

Jose Ortiz and Teresa Ku on trefoil factor 2 expression by pancreatic acinar cells, Adrian Vella on the effect of diabetes-associated variation in TCF7L2 on islet function, Matthew Webber on being a Pathway to Stop Diabetes awardee, and more! 09/04/2024

Scientific Sessions Reviewed by ADA Podcast Co-Hosts! In this special episode, the co-hosts of DiabetesBio, Diabetes Care “On Air,” Diabetes Core Update, and Diabetes Day by Day discuss highlights from the ADA’s 2024 Scientific Sessions Welcome to a very special episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the , which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care “On Air,” acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care “On Air”; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care “On Air,” DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer. This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the “bench-to-bedside” spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at until August 26.) Correction: •Dr. Carmella Evans-Molina is from the Indiana University School of Medicine •Dr. Lou Philipson is from the University of Chicago To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/32605112

Inbal Caspi and Danwei Huangfu on glucose transporters in human glucostat, Deepthi Mallela discusses the genetics of bile acids and their association with diabetes, Bernard Thorens and David Hodson revisit a 1993 “Classic” on GLP-1, and more! 08/06/2024

Jordan Wright on the exocrine pancreas, Lisa Smeehuijzen on circulating monocytes for individuals with obesity and insulin resistance, Sweet Talk with this year’s Banting Medal winner, Rury Holman, and more! 07/05/2024

DeFronzo on a novel renal-hepatic axis in endogenous glucose production, arguments for and against the current model of glucose regulation of β-cell KATP channels from Rutter and Sweet (for) and Merrins and Kibbey (against), and more! 06/12/2024

Devi Kasinathan, Zheng Guo, and Dax Fu on autoimmune diabetes, Jennifer Lee and Rebecca Salzo on WIN ADA, Olga Gupta and Rana Gupta on a “Classic” article about regional adiposity, and more! 05/06/2024

Sebastian Kalamajski on genetic aspects of adiposity-related traits; Yuval Dor on DNA methylation–based assessment of pancreas and islet cells; and Carmella Evans-Molina on the role of calcium in regulating insulin secretion. 04/02/2024

Bonus Sweet Talk episode with Christopher Newgard and Louis Philipson about the ADA’s Pathway to Stop Diabetes initiative, Céline E. Riera on her Pathway award-winning research, and more! 03/07/2024

Harry Cutler and David James on using a dual tracer test to identify insulin resistance in mice, Lori Sussel on PTPN2 regulation of metabolic flux, a preview of a special Sweet Talk episode this month, and more! Welcome to the March 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2024 issue of Diabetes. 1:15 Before getting underway with this week’s interviews, Kirk gives a quick shout-out to March’s Paper of the Month: “High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans,” by Gray et al. Although they only mention it in passing, Kirk does offer a ringing endorsement: “It’s excellent work, and all things glucagon are good.” This article is freely available at . 2:44 Darleen announces that the March DiabetesBio is actually two episodes. The first part features Darleen and Kirk interviewing authors of the feature articles of the month, and the second part is devoted to Sweet Talk with Kevin. In this special episode, Kevin delves into the ADA’s initiative with two of the initiative’s key members and one of the initiative’s award-winning researchers. 4:30 Darleen and Kirk interview Mr. and Dr. , first and last authors of “Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia.” They discuss the use of a dual tracer test and describe insights into tissue-specific insulin action. They also raise an interesting question: Could it be that the popular belief that peripheral insulin resistance leads to hyperinsulinemia is inaccurate? This article can be freely accessed at . 27:50 Kirk and Darleen then host Dr. , last author of “PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress.” Dr. Sussel and her group determined that β-cells lacking PTPN2 are more susceptible to inflammatory stress associated with T1D due to impaired glucose-stimulated insulin secretion, mitochondrial defects, and reduced glucose-induced metabolic flux, indicating a role for PTPN2 in maintaining metabolic fitness in β-cells. This article can be freely accessed at . To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/30273538

Satya Dash on erythritol and cardiometabolic disease; Jeffrey Hodgin and Alan Attie on genetic analysis of obesity-induced diabetic nephropathy in BTBR mice; and revisiting Frans Schuit’s 1998 “Classic in Diabetes” on glucagon biology Welcome to the February 2024 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, . In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2024 issue of Diabetes. 2:25: To kick things off, Darleen and Kirk are joined by of University Health Network and the Banting & Best Diabetes Centre, University of Toronto. Dr. Dash is the senior author of “Erythritol as a Potential Causal Contributor to Cardiometabolic Disease: A Mendelian Randomization Study.” Do low-calorie sweeteners possibly contribute to cardiometabolic disease? Listen to hear about the results of Dr. Dash’s study. This article can be freely accessed at . 14:52: Next, the Big 10 is well represented when Darleen and Kirk meet with Drs. (University of Michigan) and (University of Wisconsin) to discuss their fascinating collaboration on their “Genetic Analysis of Obesity-Induced Diabetic Nephropathy in BTBR Mice.” Drs. Hodgin and Attie’s study can be freely accessed at . 36:51: Sweet talk! Kevin introduces the first installment of the journal’s “” series. This new format brings timeless articles into the spotlight and showcases their value for today’s scientists. The first installment, “GPCR Promiscuity Reshapes Islet Physiology” (), was co-authored by Diabetes Associate Editor and and appears in the September 2023 issue of the journal. This commentary explores the work of Dr. Schuit, its implications for the understanding of diabetes, and how it laid the foundation for a rethinking of a traditional role of glucagon. Here, in this enlightening discussion, Dr. Schuit takes us through the historical context that led to the hypothesis and conclusions of his January 1998 classic, “Dual Glucagon Recognition by Pancreatic β-Cells via Glucagon and Glucagon-Like Peptide 1 Receptors” (), and Dr. Campbell explains how rediscovering the concepts and findings of Dr. Schuit’s work has informed his current research. Drs. Schuit and Campbell conclude the discussion by sharing their thoughts on glucagon research and diabetes treatment. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/29826323

Introducing DiabetesBio! A chat with editor David D’Alessio, discussing fatty acids and GDF15 with “Paper of the Month” author Gregory Steinberg, and remembering Daniel Porte Jr. 12/29/2023

Introducing DiabetesBio! A chat with editor David D’Alessio, discussing fatty acids and GDF15 with “Paper of the Month” author Gregory Steinberg, and remembering Daniel Porte Jr. Welcome to the premiere episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In each episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams will discuss the latest and greatest content in Diabetes. The team kicks off this first episode with some brief introductions before passing the mic to Diabetes editor-in-chief David D’Alessio (5:35), who shares his experiences as the editor of the journal and describes new initiatives involving the journal. 15:35: In addition, Dave and the team discuss the legacy and contributions of Daniel Porte Jr. Dan passed away at the age of 91 in May 2023, and he is the subject of a “Profiles in Progress” remembrance by Steven Kahn et al. in the January 2024 issue of Diabetes: . 20:42: Darleen and Kirk then interview Dr. Gregory Steinberg of McMaster University. Dr. Steinberg is the senior author of “Fatty Acids Increase GDF15 and Reduce Food Intake Through a GFRAL Signaling Axis.” This article, which can be freely accessed at , is the editor-selected Paper of the Month for the January 2024 issue of Diabetes. 31:49: In the “Sweet Talk” segment, Darleen and Kirk wrap up the episode by reviewing several interesting articles in January 2024 issue of Diabetes. Studies highlighted in this segment include: M.W. Pataky et al. Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors. K. Motomura et al. Single-Cell Transcriptome Profiling of Pancreatic Islets From Early Diabetic Mice Identifies Anxa10 for Ca2+ Allostasis Toward β-Cell Failure. C Jiménez-Sánchez et al. Lysophosphatidylinositols Are Upregulated After Human β-Cell Loss and Potentiate Insulin Release. C.M. Cohrs et al. Bridging the Gap: Pancreas Tissue Slices From Organ and Tissue Donors for the Study of Diabetes Pathogenesis. To learn more about Diabetes and DiabetesBio, please visit . Thank you for listening! /episode/index/show/3622f9f5-a489-40b0-ab91-d001af46e76d/id/29271798

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