Episode 3 - Jimmy O'Keefe and Navigating Life Science Capital Projects
Release Date: 10/23/2025
Episode 3 - Jimmy O'Keefe and Navigating Life Science Capital Projects
Design, Build and Deliver
My guest in this episode is James O'Keefe. James is Vice President at Hart Engineering Corporation, where he oversees complex mechanical construction projects across the life sciences, pharmaceutical, and industrial sectors. Since joining Hart in 2008 as a Northeastern University Co-Op student, James has advanced through multiple engineering and project management roles. From a Co-op to VP - a real example if you need one. With nearly 20 years of experience, he has led some of Hart’s most demanding installations in New England. He is deeply engaged in advancing life science industry...
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Episode 2 - Michael Kelly and the Future of Pharmaceutical Facilities
Design, Build and Deliver
My guest in this episode is Michael Kelly. Mike is the Director of Bio-process Engineering at Hart Design Group, where he has been leading innovative process solutions. With a career spanning top-tier biotech and engineering firms like Parsons Corporation, Biogen, Amgen, and Moderna, Mike has held increasingly senior roles across engineering, project management, and facilities operations. He has a degree in Chemical Engineering from Widener University, and an MBA from Bentley University. He brings technical acumen along with strategic thinking which were abundantly clear in this interview....
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Episode 1 - David Rampone and Life Science Industry Changes and Challenges
Design, Build and Deliver
My guest in today’s episode is David Rampone, a leader whose impact extends far beyond engineering and construction. David is President of Hart Engineering Corporation. He has spent decades not just building facilities - but building trust, excellence, and a legacy of craftsmanship that stands the test of time. David’s leadership reaches deep into the heart of Rhode Island and the life sciences industry. In addition to guiding Hart Engineering, he serves as Chairman of the Miriam Hospital Foundation Board of Trustees, and chairs or sits on the boards of numerous education, labor, safety,...
info_outlineMy guest in this episode is James O'Keefe. James is Vice President at Hart Engineering Corporation, where he oversees complex mechanical construction projects across the life sciences, pharmaceutical, and industrial sectors. Since joining Hart in 2008 as a Northeastern University Co-Op student, James has advanced through multiple engineering and project management roles. From a Co-op to VP - a real example if you need one.
With nearly 20 years of experience, he has led some of Hart’s most demanding installations in New England. He is deeply engaged in advancing life science industry standards through active participation in the New England Mechanical Contractors Association (NEMCA), the International Society for Pharmaceutical Engineers (ISPE), and the UA Local 51 Joint Apprenticeship Training Committee (JATC). Jim holds a degree in Mechanical Engineering from Northeastern University.
In this chat, Jim and I delve into
- the intricacies of capital projects,
- the differences between design build and design assist methodologies,
- the importance of various drawing types in project management,
- strategies to avoid delays and cost overruns, and
- the growing trend of local sourcing in the life science construction industry.
Additionally, we address the critical shortage of skilled labor and the value of apprenticeship programs, while also touching on personal insights regarding work-life balance and the importance of effective communication in project execution.
Takeaways:
- Design build integrates engineering and contracting under one entity.
- Design assist involves contractor input during the design phase.
- Different drawing types serve specific purposes in project management.
- Early conversations with stakeholders can prevent project delays.
- Local sourcing is becoming more popular for better control and quality.
- Choosing the right materials can lead to significant cost savings.
- The construction industry faces a shortage of skilled labor.
- Apprenticeship programs provide valuable education without debt.
- Work-life balance is essential for long-term career satisfaction.
Quatable Quotes:
- "It's a lot easier to change things on paper than in a facility."
- "We can streamline everything."
Jim can be reached at jokeefe(at)hartcompanies.com and on LinkedIn.
I found my discussion with Jim very timely and insightful. I hope you do too.
Here's James O'Keefe.