Ep. 6 - B-cells vs. Complement in IgAN: A Look at the Data from Kidney Week 2024 (with Dr. Vlado Perkovic)
Release Date: 12/09/2024
Ep. 6 - B-cells vs. Complement in IgAN: A Look at the Data from Kidney Week 2024 (with Dr. Vlado Perkovic)
Biotech Matters
sits down with Vlado Perkovic, MBBS, PhD, to discuss the IgA nephropathy trial data presented at Kidney Week 2024 in San Diego. Jeff begins by asking Dr. Perkovic to talk about why targeting B-cells is an attractive target, and why BAFF/APRIL might prove more promising than CD20. The two then discuss the data with two agents in development for the treatment of IgAN, atacicept (targeting BAFF/APRIL) and sibeprenlimab (targeting APRIL only). The conversation then pivots to the prospect of complement inhibition with FABHALTA® (iptacopan) in IgA nephropathy, including a comparison of the...
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Ep. 5 - It’s ASN Kidney Week 2024! Here’s What We’re Excited About (with Dr. Beatrice Goilav)
Biotech Matters
welcomes back returning guest nephrologist Beatrice Goilav, MD, to discuss the program featured at Kidney Week 2024 in San Diego. Dr. Goilav reflects on what has happened in the field since last year’s Kidney Week conference, as well as her hopes for what will be presented at a variety of sessions, including more data in IgA nephropathy, lupus nephritis, and FSGS. She also offers her perspective on the newest advancements with complement inhibitors in glomerular diseases – including approval of FABHALTA® (iptacopan) in IgA nephropathy – as well as recommendations for educational...
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Ep. 4 - ADC Alchemy: A Post-ASCO Discussion
Biotech Matters
Bluestar Managing Director is back from the ASCO conference in Chicago and joins Principal on the podcast again, this time to talk about all things antibody drug conjugates (ADCs) in oncology. Given the number and value of deals in this space over the past couple of years, as well as the 170+ ADCs now in clinical development, Jeff asks Erin to take stock of what we’ve learned about the potential of these molecules, with all their moving parts, and opine on what lies ahead. Over the course of this brief conversation, Erin and Jeff touch on some key questions about ADCs, including: •...
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Ep.3 What We’re Watching at ASCO 2024
Biotech Matters
As the Bluestar team prepares to head to ASCO 2024 this upcoming weekend, Bluestar Principal Jeff Fineberg sits down with Bluestar Managing Director Erin Olsen to talk about interesting abstracts related to two topics: What are the unmet needs in 1L therapy? The KRAS G12C mutation landscape
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Ep. 2 - Making Sense of the Latest IgAN Trials (with Dr. Pietro Canetta)
Biotech Matters
After attending ASN Kidney Week, Bluestar Principal Jeff Fineberg sits down with Dr. Pietro Canetta to talk all things IgA nephropathy (IgAN). After Dr. Canetta provides a brief summary of his IgAN lecture at Kidney Week, Emerging Therapeutic Options in IgA Nephropathy, the two discuss the Filspari (sparsentan) data presented from both the PROTECT study, in IgAN, the DUPLEX study, in FSGS. From there, Dr. Canetta opines on the value of surrogate endpoints in predicting the three D’s of CKD: death, dialysis, and doubling of serum creatinine (SCr). Dr. Canetta briefly discusses...
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Ep. 1 - What We’re Looking for at ASN Kidney Week 2023: A Conversation with Dr. Beatrice Goilav
Biotech Matters
In the first ever Biotech Matters podcast episode, Principal Jeff Fineberg, PhD, sits down with nephrologist Beatrice Goilav, MD, to talk all things Kidney Week. Dr. Goilav offers her thoughts on an ideal day-by-day itinerary, as well as her hopes for what will be presented at a variety of sessions, including drug trials in IgAN, and new studies of SGLT2 inhibitors. She also offers her perspective on the potential for complement inhibitors in glomerular diseases, and which of these drugs in development she is most interested in. Finally, she makes some recommendations on poster abstracts to...
info_outlinePrincipal Jeff Fineberg, PhD sits down with Vlado Perkovic, MBBS, PhD, to discuss the IgA nephropathy trial data presented at Kidney Week 2024 in San Diego. Jeff begins by asking Dr. Perkovic to talk about why targeting B-cells is an attractive target, and why BAFF/APRIL might prove more promising than CD20. The two then discuss the data with two agents in development for the treatment of IgAN, atacicept (targeting BAFF/APRIL) and sibeprenlimab (targeting APRIL only). The conversation then pivots to the prospect of complement inhibition with FABHALTA® (iptacopan) in IgA nephropathy, including a comparison of the strategy to target certain complement factors/pathways over others in IgAN. Finally, the discussion takes a broader lens to the evolving IgAN treatment landscape, that may include both of these novel therapeutic mechanisms, in addition to recently approved drugs FILSPARI® (sparsentan) and TARPEYO® (budesonide), as well as other CKD therapeutic classes, such as SGLT2 inhibitors and GLP-1 receptor agonists.
Vlado Perkovic Bio
Vlado Perkovic is the Provost at UNSW Sydney and Scientia Professor at UNSW, and was previously the Dean of the Faculty of Medicine and Health as well as Professorial Fellow at The George Institute, Australia, and a Staff Specialist in Nephrology at the Royal North Shore Hospital. His research focus is clinical trials and epidemiology, in particular, in preventing the progression of kidney disease and its complications. He leads several major international clinical trials with a focus on diabetic kidney disease, IgA nephropathy and CKD more broadly, and has Chaired the Steering Committees of many trials including CREDENCE, FLOW, TESTING, PROTECT, and APPLAUSE, along with several ongoing trials.
Dr. Perkovic holds a Doctor of Philosophy from the University of Melbourne and is a Fellow of the Royal Australasian College of Physicians, of the Australian Academy of Health and Medical Sciences, and of the American Society of Nephrology.