From Symptoms to Systems How Jona Gut Testing Transforms Clinical Decision Making | Helen Messier, MD, PhD, Leo Grady, PhD, & Lawrence Kosinski, MD
Release Date: 02/10/2026
Redefining Medicine with special guest Dr. Dian Ginsberg
Redefining Medicine
On the next episode of Redefining Medicine, we are excited to feature Dr. Diane Ginsberg, a leading voice in pre- and perimenopause care and a strong advocate for rethinking how we approach women’s hormonal health. IIn this episode, Dr. Ginsberg challenges the traditional reliance on standard blood testing, explaining how hormone levels - particularly estrogen - can fluctuate significantly and still appear “normal” on conventional lab results. She highlights how these fluctuations can profoundly impact the brain and overall well-being, often leaving women misdiagnosed or...
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Implementing Triple Satiety Hormone Activators for Metabolic and Weight Health | Myles Spar, MD & Edward Walker, PhD
Redefining Medicine
In this episode of Innovations in Clinical Implementation, recorded live at LongevityFest 2025, hosts Laurie Hofmann and Dr. Lexi Gonzales explore one of the most pressing challenges in metabolic and weight care: how to support meaningful weight loss without compromising lean muscle mass. They are joined by Dr. Myles Spar, a double board-certified physician specializing in integrative internal medicine, and Dr. Edward Walker, researcher at New Zealand’s Plant and Food Research and lead scientist behind Amarasate, the bitter hops extract at the center of ’s appetite control formula....
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How Clinicians Become AI Producers vs. Consumers | Sunjya Schweig, MD
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast, Dr. Lexi Gonzales and Dr. Sunjya Schweig discuss the shift for clinicians from passively consuming AI to actively building custom tools to improve patient outcomes and reduce clinical friction. Key topics include the use of custom GPTs created by uploading specific data, the potential of "vibe coding" for building apps with natural language, and the evolution of AI scribes like as a "second brain." The conversation also addresses challenges in integrating AI with legacy EMRs, the push for "health record equity," and...
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Supercharging Clinical Practice | Sunita Mohanty, MBA & Crystal Brust, PA-C
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores how AI is revolutionizing functional medicine workflows with guests Sunita Mohanty and Crystal Brust. Sunita Mohanty is the CEO and co-founder of and. Crystal Brust is a Stanford-trained functional medicine Physician Assistant and founder of Farm to Functional Medicine. The conversation highlights how the Vibrant Practice platform addresses clinician burnout by integrating AI directly into the electronic health record (EHR) to automate documentation and...
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Redefining Medicine with special guest Dr Tom O'Bryan
Redefining Medicine
On the next episode of Redefining Medicine, we are thrilled to feature Dr. Tom O'Bryan, a globally recognized expert in functional medicine and a passionate advocate for improving health outcomes through education and awareness. Dr. O'Bryan is renowned for his dedication to uncovering the root causes of chronic illness and empowering individuals to take control of their health. In this episode, Dr. O'Bryan delves into the critical role of inflammation as a key mechanism underlying many of the leading causes of death identified by the CDC. He explains how inflammation acts as a common...
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Biofilm Focused Clinical Strategies for Human Health | Jocelyn Strand, ND
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast, hosts Dr. Lexi Gonzales and Dr. Chris D'Adamo explore the critical role of biofilm management in gut health and longevity with Dr. Jocelyn Strand. Dr. Strand is a Naturopathic Doctor and the Director of Clinical Education and Research at , bringing over a decade of primary care experience specializing in GI disorders, Lyme disease, and autoimmune conditions. The discussion defines biofilms as an "invisibility cloak" that protects microorganisms from the immune system, leading to chronic inflammation and toxicity when...
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Liver Health Optimization in Clinical Practice with Dose | Kiran Krishnan, PhD
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Dr. Lexi Gonzales and Jessica Carter discuss functional liver health with Dr. Kiran Krishnan—a research microbiologist and globally recognized expert on the human microbiome and co-founded Microbiome Labs. Dr. Krishnan argues that standard enzymes like AST and ALT are late-stage markers of damage, and instead advocates for proactive support using , a clinically validated liquid therapeutic that serves as a foundational tool for metabolic health and reduces pill burden. The...
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Redefining Medicine with special guest Vincent Pedre, MD
Redefining Medicine
Dr. Vincent Pedre, a renowned expert in gut health, discusses his book The GutSMART Protocol in the upcoming episode of Redefining Medicine. In this episode, he emphasizes the importance of personalized approaches to gut health, highlighting that there is no "one-size-fits-all" solution. He delves into the connection between gut health and overall well-being, including its impact on skin health. The book also includes a quiz designed to help readers identify their specific gut-related issues, including those that may manifest as skin-related conditions. This quiz serves as a tool to...
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Building Longevity Through Immune Health with Beta Glucan | Jill Carnahan, MD
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast, hosts Jessica Carter and Dr. Chris D'Adamo interview Dr. Jill Carnahan, a functional medicine physician internationally recognized for treating complex chronic illnesses, about the critical role of beta glucans in immune resilience – which she champions as the foundation of longevity. Dr. Carnahan, discusses the importance of using high-purity beta glucans, profiling , and details their use in treating complex conditions like Lyme disease, Bartonella, and cancer where the immune system is often suppressed. The...
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Liposomal Oral Peptides for Immune Regulation, Tissue Repair, and Longevity in Clinical Practice | Christopher Shade, PhD
Redefining Medicine
In this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, hosts Dr. Lexi Gonzales and Tom Blue explore the frontier of liposomal peptide therapy with Dr. Christopher Shade—the founder and CEO of and an internationally recognized expert on environmental toxicants who pioneered the use of lipid-based nanoparticle delivery systems. Dr. Shade argues that "inflammaging" and endotoxemia often block the efficacy of standard hormone therapies by downregulating receptors, and he advocates for using specific liposomal peptides like BPC-157, KPV, and...
info_outlineIn this episode of the Innovations and Clinical Implementation podcast recorded at LongevityFest 2025, host Dr. Lexi Gonzales explores the intersection of AI and gut health with Dr. Helen Messier, a physician and molecular immunologist who serves as the Chief Medical and Science Officer at Fountain Life; Dr. Leo Grady, the founder of Jona and an AI expert who previously led the team achieving the first FDA approval for an AI product in pathology; and Dr. Lawrence Kosinski, a gastroenterologist and founder of Sonar MD who is a national leader in value-based care. The panel discusses how Jona’s AI platform processes over 220,000 studies to identify dysbiotic patterns that antedate clinical disease—ranging from metabolic liver disease and colon polyps to Parkinson’s and cardiovascular issues linked to TMAO—thereby moving clinical focus from "symptoms to systems". The experts emphasize the mechanism of the gut-brain axis, noting that metabolites like butyrate derived from soluble fiber are essential for stabilizing the blood-brain barrier and DNA, while warning that popular GLP-1 agonists, though effective for weight loss, can "collapse" microbiome diversity and require careful monitoring.
For access to episode resources, click HERE.