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Episode 223: Orforglipron 101: The Next Big Thing in Obesity Medications

Back on Track: Achieving Healthy Weight Loss

Release Date: 12/01/2025

Episode 250: Why Your Weight Loss Has Stalled — 7 Reasons Behind the Plateau show art Episode 250: Why Your Weight Loss Has Stalled — 7 Reasons Behind the Plateau

Back on Track: Achieving Healthy Weight Loss

I had a patient walk into my office recently looking frustrated. She sat down, crossed her arms, and said, "Dr. Shelly, my medication has stopped working. I lost 32 pounds, but for the last six weeks my weight hasn't budged. Am I immune to this medication?" If you've looked at the scale lately and wondered the same thing, this episode is for you. In this episode, I'm walking you through the seven most common reasons weight loss plateaus happen, from still being on a starting dose to hidden medical conditions like thyroid issues or PCOS that can quietly work against you. I'll also break down...

info_outline Episode 249: Do I Have to Stay on My Medication Forever? What the ATTAIN Maintain Trial Reveals show art Episode 249: Do I Have to Stay on My Medication Forever? What the ATTAIN Maintain Trial Reveals

Back on Track: Achieving Healthy Weight Loss

"Doc, do I need to take this forever?" It's one of the most common questions I hear in my office, whether it's someone's very first visit or someone who's already lost 30, 40, even 80 pounds and is feeling great. In this episode, I break down why your body fights so hard to regain weight after you lose it, and why that's biology, not failure. I walk through the new ATTAIN Maintain trial, a study of 376 adults who had already lost significant weight on tirzepatide or semaglutide, testing whether switching to an easier once-daily oral GLP-1 could help them keep the weight off, instead of just...

info_outline Episode 248: Am I Going to Go Blind on a GLP-1? Understanding the NAION Headlines show art Episode 248: Am I Going to Go Blind on a GLP-1? Understanding the NAION Headlines

Back on Track: Achieving Healthy Weight Loss

If you've seen headlines linking Ozempic and other GLP-1 medications to sudden eye strokes, I want to stop the panic right here.  In this episode, I break down what the research on NAION actually shows, who's really at risk, and why the scary relative-risk numbers you're seeing online don't tell the whole story. I walk you through what NAION is, why patients on semaglutide often already carry the underlying risk factors that get left out of the clickbait, and what the difference is between an observational study raising a signal and a randomized trial proving cause and effect. I also...

info_outline Episode 247: The Menopause Metabolism Shift: How Foundayo Changes the Game show art Episode 247: The Menopause Metabolism Shift: How Foundayo Changes the Game

Back on Track: Achieving Healthy Weight Loss

I hear this from so many of my patients: "Dr. Shelly, I haven't changed anything—not my diet, not my exercise—but I'm gaining weight and my body just doesn't respond the way it used to." If you're a woman in your 40s or 50s, you're probably nodding right now. In this episode, I'm walking you through exactly why menopause causes weight gain, why it has nothing to do with willpower, and what breakthrough new research reveals about Foundayo—an oral GLP-1 medication—and how it helps restore the biological signals that become harder to access during this life stage.  I'm sharing real...

info_outline Episode 246: Do GLP-1 Medications Affect Your Bones? show art Episode 246: Do GLP-1 Medications Affect Your Bones?

Back on Track: Achieving Healthy Weight Loss

A patient asked me this recently: "Dr. Shelley, I've heard that GLP-1 medications can cause muscle loss. Does that mean they can hurt my bones too?" It's an excellent question—and one we don't talk about nearly enough. In this episode, I'm walking you through what the research actually shows about GLP-1 medications and bone health, why weight loss itself poses a different risk to your skeleton, and the five non-negotiable steps you need to take to protect your bones while losing weight. This is the bone health conversation you need to hear before—or while—taking a GLP-1. Episode...

info_outline Episode 245: Retatrutide Delivers Bariatric-Level Weight Loss: Breaking Down the TRIUMPH-1 Trial from ADA 2026 show art Episode 245: Retatrutide Delivers Bariatric-Level Weight Loss: Breaking Down the TRIUMPH-1 Trial from ADA 2026

Back on Track: Achieving Healthy Weight Loss

Can retatrutide finally be the breakthrough obesity treatment we've been waiting for? The answer is yes—and the data is stunning. In this episode I'm walking you through the biggest obesity medicine discovery from the ADA's 86th Scientific Session: retatrutide, a triple hormone receptor agonist showing weight loss results that rival bariatric surgery. You'll learn what makes retatrutide different from Wegovy and Zepbound, the stunning results from the Triumph 1 trial, what the side effects actually look like, and when this medication will finally be available. Weight loss medications are...

info_outline Episode 244: How to Restart a GLP-1s show art Episode 244: How to Restart a GLP-1s

Back on Track: Achieving Healthy Weight Loss

Can I restart my GLP-1? The answer is yes — but it requires a strategic plan.  In this episode I'm walking you through exactly what happens to your body when you restart a GLP-1, why the timing of your break matters more than you think, how to restart safely without landing yourself in misery, the biggest mistakes I see patients make, and how to get back on track without shame or guilt. Restarting doesn't have to mean starting completely over. But how you restart matters. Listen now!   Episode Highlights: Why restarting at your previous dose will make you seriously sick What...

info_outline Episode 243: Why people stop taking GLP-1s show art Episode 243: Why people stop taking GLP-1s

Back on Track: Achieving Healthy Weight Loss

You stopped your GLP-1 and now you're wondering can I just restart where I left off? Why am I so hungry again? Why are the side effects back? Did the medication stop working? These are questions I hear all the time in my practice. And the answer is not as simple as picking back up where you stopped. In this episode I am walking you through exactly what happens biologically when you stop a GLP-1, why restarting feels different than when you first started, how to restart safely, the common mistakes I see patients make, and how to get back on track mentally without shame. A pause does not erase...

info_outline Episode 242: Self-Pay, Savings Programs, and Smarter Strategies for GLP-1 Medications show art Episode 242: Self-Pay, Savings Programs, and Smarter Strategies for GLP-1 Medications

Back on Track: Achieving Healthy Weight Loss

A patient finally decides to prioritize their health. They wait weeks for an appointment. We talk, we plan, and they leave with hope. Then the pharmacy calls with a price tag over $1,000 a month and that hope disappears. If that's happened to you, I made this episode for you. Because what most patients don't know is that there are real, legitimate ways to make this work and I'm breaking all of them down today. An insurance denial is not a verdict on your health or your worth. It just means we need to get strategic. Listen now!   Episode Highlights: Why I never let my patients stop at...

info_outline Episode 241: Which Weight Loss Medication Is Right for You? show art Episode 241: Which Weight Loss Medication Is Right for You?

Back on Track: Achieving Healthy Weight Loss

People keep asking the same question: what’s actually the difference between all these weight loss medications?  Ozempic. Wegovy. Mounjaro. Zepbound. Foundayo. Wegovy pill. Some of these medications are injections, some are pills, some are FDA-approved for diabetes, others for weight loss, and some are actually the same medication with completely different brand names. So I'm breaking it all down for you today — in plain language — because the confusion alone is keeping people from getting the treatment they need. The real problem isn't just the brand names. It's that without...

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More Episodes

If you've been waiting for a GLP-1 weight loss medication that doesn't require injections, special timing, or refrigeration—this episode is for you. Learn about the groundbreaking oral pill that could hit the market as early as 2026.

For years, effective obesity medications have meant needles. But Orforglipron could change everything. In this episode, I break down the science, clinical trial results, and approval timeline for this first-of-its-kind once-daily pill that delivers GLP-1 benefits without the injection barriers.

Whether you're needle-averse, struggle with injection site reactions, or simply want more convenient options, this new medication could expand access to life-changing obesity treatment.

 

Episode Highlights:

  • What makes Orforglipron different from Wegovy, Zepbound, and oral semaglutide

  • Clinical trial results: 12.4% average weight loss over 72 weeks

  • Why this oral pill doesn't require fasting or special timing like other oral GLP-1s

  • The FDA accelerated review process and potential 2026 approval timeline

  • Who benefits most: patients with needle phobia, injection site reactions, or seeking maintenance therapy

  • What to expect regarding insurance coverage and access once approved

 

Connect with Dr. Alicia Shelly:

 

About Dr. Alicia Shelly

Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.

 

Resources:

FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!) 👉 Click