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Episode 238: CagriSema: The Next Generation of Obesity Treatment

Back on Track: Achieving Healthy Weight Loss

Release Date: 04/27/2026

Episode 239: Why did my GLP-1 get denied? show art Episode 239: Why did my GLP-1 get denied?

Back on Track: Achieving Healthy Weight Loss

Your weight loss medication was denied. That moment of hope is gone. But this is not a ‘you’ problem. It's a system problem. In this episode, I break down why insurance denials for weight loss medications happen so frequently, and more importantly, what you can actually do about it. From formulary exclusions to step therapy requirements to the documentation timing that can reset your entire approval clock the barriers are real, but they are navigable. A denial does not mean you failed. It means you hit a wall in a system built with gaps. Understanding how that system works is the first...

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Episode 238: CagriSema: The Next Generation of Obesity Treatment show art Episode 238: CagriSema: The Next Generation of Obesity Treatment

Back on Track: Achieving Healthy Weight Loss

Weight loss plateaus on GLP-1 therapies such as Wegovy and Zepbound are increasingly understood as a function of biological adaptation rather than patient noncompliance. In this episode I will be discussing CagriSema, an investigational combination therapy expected to launch between late 2026 and early 2027. The treatment combines semaglutide and cagrilintide, targeting complementary mechanisms that regulate appetite and satiety. Clinical trial data indicate weight reduction of up to 22.7%, suggesting improved efficacy relative to existing monotherapies. The development reflects a broader...

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Episode 237: Foundayo Weight Loss Pill Explained: New GLP-1 Alternative to Wegovy show art Episode 237: Foundayo Weight Loss Pill Explained: New GLP-1 Alternative to Wegovy

Back on Track: Achieving Healthy Weight Loss

If you’re looking for weight loss options but don’t want injections, things just changed in a big way. In this episode, I break down a new class of weight loss pills, including Foundayo (orforglipron), the newest GLP-1 option that was just approved. Unlike older treatments, this pill is designed to be simple. No fasting. No strict timing. You can take it with food or even coffee. We also look at how it compares to the oral Wegovy pill and what that means for people who want real results without shots. There are now two real pill options in the weight loss space, and choosing the right one...

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Episode 236: Wegovy HD medication show art Episode 236: Wegovy HD medication

Back on Track: Achieving Healthy Weight Loss

If Wegovy has helped you — but not enough — the answer may not be more willpower. It may be a higher dose. The FDA just approved a new 7.2mg version of Wegovy, and the clinical data is turning heads. In this episode, I break down everything you need to know about this new higher dose — what the research shows, who it's designed for, and what it actually means for your weight loss journey. Weight loss medicine just crossed a new threshold. This isn't just a bigger dose, it's a meaningful new option for people who need more help reaching goals that can transform their health. Listen now!...

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Episode 235: How Does PCOS Make Me Gain Weight? show art Episode 235: How Does PCOS Make Me Gain Weight?

Back on Track: Achieving Healthy Weight Loss

You're doing everything right — watching what you eat, trying to stay active — and still the weight won't budge. If you have PCOS, this isn't a willpower problem. It's biology. And once you understand the cycle driving it, you can finally start to break it. PCOS creates a vicious cycle between high androgens, insulin resistance, and weight gain and each one feeds into the others. Your body isn't working against you randomly. There are real mechanisms at play, and understanding them is the first step to taking back control. In this episode, I break down exactly what's happening inside your...

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Episode 234: Is My Thyroid Making Me Gain Weight? show art Episode 234: Is My Thyroid Making Me Gain Weight?

Back on Track: Achieving Healthy Weight Loss

If you've been struggling to lose weight and your thyroid came back abnormal, it's natural to connect the dots. But here's what I need you to know, the thyroid is not the whole story. In this episode, I break down exactly what your thyroid does and doesn't do when it comes to your weight. Yes, hypothyroidism affects your weight. But research shows it typically causes only 5 to 10 pounds of gain — and most of that is water retention, not body fat. Treating it will help you feel better, but it won't magically melt the weight away. And please, do not ask your doctor for extra thyroid medication...

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Episode 233: Why Am I Not Losing Weight? The Surprising Problem of Undereating show art Episode 233: Why Am I Not Losing Weight? The Surprising Problem of Undereating

Back on Track: Achieving Healthy Weight Loss

If you've been eating barely anything and the scale still won't move, the problem might not be that you're eating too much. It might be that you're not eating enough.  And there's science behind why. "Why am I not losing weight?" It's the most frustrating question in my clinic. And the answer often surprises people.  Today, I'm answering it publicly — with research, not guesswork. In this episode, I break down exactly what happens inside your body when you undereat, why cutting calories too aggressively can backfire, and the six practical steps to get your metabolism working for...

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Episode 232: Five Things You Need to Know About the New Wegovy Pill show art Episode 232: Five Things You Need to Know About the New Wegovy Pill

Back on Track: Achieving Healthy Weight Loss

You've heard about the Wegovy shot. Now there's a pill — and the confusion is already spreading. Is it the same? Does it work as well? Can you take it with your other medications? In December, the FDA approved an oral form of semaglutide specifically for weight management and cardiovascular risk reduction. That's a game-changer — but only if you know how to use it correctly. Take it wrong and it won't work at all. In this episode, I will break down the five things you need to know about the new Wegovy pill. I will talk about the science behind SNAC technology, why this medication goes...

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Episode 231: What happens when you stop your GLP-1? show art Episode 231: What happens when you stop your GLP-1?

Back on Track: Achieving Healthy Weight Loss

If you're on Wegovy, Zepbound, Ozempic, or Mounjaro — and worried about what happens when you stop — this episode is for you. The fear of gaining it all back is real. But weight regain is not inevitable. It's manageable. And I'm going to show you how. “What happens when you stop your GLP-1?” This is one of the most common questions I get in my clinic every single week. It's time I answered it publicly — with science, not fear. In this episode, I break down exactly what happens in your body when you stop your GLP-1, why weight regain happens, and the five pillars you need to protect...

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Episode 230: Top 5 Weight Loss Myths Your Doctor Wishes You’d Stop Believing show art Episode 230: Top 5 Weight Loss Myths Your Doctor Wishes You’d Stop Believing

Back on Track: Achieving Healthy Weight Loss

Every single week in my clinic, I see smart, motivated people stuck in their weight loss journey not because they're doing something wrong, but because they believe something wrong. The myths surrounding weight loss are so deeply embedded in our culture that even some physicians still repeat them. And the cost? Shame, delayed treatment, and people giving up on themselves unnecessarily. I've spent over a decade watching these myths do real damage and I'm done staying quiet about it. In this episode, I'm breaking down the top 5 weight loss myths I wish my patients would stop believing and...

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More Episodes

Weight loss plateaus on GLP-1 therapies such as Wegovy and Zepbound are increasingly understood as a function of biological adaptation rather than patient noncompliance.

In this episode I will be discussing CagriSema, an investigational combination therapy expected to launch between late 2026 and early 2027. The treatment combines semaglutide and cagrilintide, targeting complementary mechanisms that regulate appetite and satiety.

Clinical trial data indicate weight reduction of up to 22.7%, suggesting improved efficacy relative to existing monotherapies.

The development reflects a broader shift toward combination-based treatment models, consistent with approaches used in managing chronic conditions such as diabetes and hypertension. 

Listen to the episode for a closer look at what this could mean for treatment pathways and patient outcomes.

Episode Highlights:

  • Why plateaus happen and what your body is actually doing

  • What CagriSema is and how its two-ingredient formula works

  • What the REDEFINE trials show including how it stacks up against Tirzepatide

  • Who this medication is most likely to help

  • Why the best plan is still the one that's working for you right now

Connect with Dr. Alicia Shelly:

About Dr. Alicia Shelly

Dr. Alicia Shelly was raised in Atlanta, GA. She received her Doctorate of Medicine from Case Western Reserve University School of Medicine in Cleveland, OH.  Dr. Shelly has been practicing Primary Care and Obesity medicine since 2014.  In 2017, she became a Diplomat of the American Board of Obesity Medicine. She is the lead physician at the Wellstar Medical Center Douglasville. She started a weekly podcast & Youtube channel entitled Back on Track: Achieving Healthy Weight loss,  where she discusses how to get on track and stay on track with your weight loss journey. She has spoken for numerous local and national organizations, including the Obesity Medicine Association, and the Georgia Chapter of the American Society of Metabolic and Bariatric Surgeons. She has been featured on CNN, Fox 5 News, Bruce St. James Radio show, Upscale magazine, and Shape.com. She was named an honoree of the 2021 Atlanta Business Chronicle's 40 under 40 award. She also is a collaborating author for the, “Made for More: Physician Entrepreneurs who Live Life and Practice Medicine on their own terms''.

 

Resources:

FREE! Discover the 5 Reasons Your Weight-Loss Journey Has Gotten Derailed (And How To Get Back On Track!) 👉 Click