From “It’s Just Aging” to Strong Joints Again: The Cellular Repair Playbook with Michelle Skaff
Release Date: 01/13/2026
My Personal Peptide Stack and Why I'm Taking a Break: BPC-157, TB-500, Microdosing Retatrutide, AOD-9604, GHK-Cu, NAD, Selank and Semax
Biohacking with Brittany
I'm a biohacker with a peptide fridge, and right now I am injecting absolutely nothing. That is probably not what you expected me to say. The internet makes it look like the goal is more compounds, stacked higher, forever. It is not. The goal is to use the right tool for a specific window, then come off it. In this solo episode I open my actual fridge. I walk through every peptide I have run recently, the real dose, why it went in, why it came out, and why I am on a full break right now. I cover my injury repair pair BPC-157 and TB-500, my body composition experiments with AOD-9604 and a...
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Peptides Just Got National Validation: Inside the Landmark FDA Vote on BPC-157, TB-500, KPV, MOTS-c, DSIP, Epitalon + Semax
Biohacking with Brittany
This is a landmark day for peptides! I recorded this at 6 AM the morning between day one and day two of the FDA's Pharmacy Compounding Advisory Committee (PCAC) meeting, and I'm breaking down exactly what happened, why it matters, and what it means for you depending on where you live. On day one, the committee voted YES on all four peptides they reviewed: BPC-157, TB-500, KPV, and MOTS-c. This went against the FDA scientists' own recommendation. There was an audible gasp in the room. Today they're voting on DSIP, Epitalon, and Semax, and I expect all three to pass too. If you'd like to work...
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Optimize your Blood Sugar: Belly Fat, Prediabetes, Peptides, Type 3 & 4 Diabetes, Insulin Resistance, CGMs, Inositol and GLP-1's | Her Stack Series
Biohacking with Brittany
Blood sugar is the master dial. If your energy crashes at 3pm, if the cravings run you, if the belly weight will not move no matter how clean you eat, this is not a willpower problem. It is a blood sugar problem, and it is fixable. In this episode I break down blood sugar for women from the ground up: what glucose and insulin actually do, the six levers that throw them off, the full diabetes spectrum from prediabetes through Types 1 to 4 (including the lean, skinny fat Type 4 that surprised me), and the exact labs and CGMs to run. Then I give you my full stack across four pillars: nutrition,...
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How to Glow Up in 8 Weeks: Supplements, Collagen, Biohacks and Peptides (GHK-Cu, Retatrutide, MOTS-c, AOD 9604) | Her Stack Series
Biohacking with Brittany
You have a wedding, a vacation, a babymoon, a reunion, or a big shoot in about two months, and you want to walk in glowing. In this episode I give you my full 8 week glow up protocol, the same one I build for my one on one clients, and it is all from the inside out. I break down what glow actually is on a physiological level: collagen, glycation, inflammation and puffiness, gut health, circulation and lymph, and body composition. Then I walk you through the labs to run, my three pillars of nutrition, lifestyle, and supplements, and the peptides I reach for when a client wants skin, hair, tan,...
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The Complete Sleep Protocol: Peptides, Supplements, Blood Sugar, Blue Light, Cooling Mattresses + The 3 AM Fix That Changed Everything | Her Stack Series
Biohacking with Brittany
In this episode, I'm giving you the full sleep protocol I built for myself and for the women I work with. Not just how to sleep longer, but how to make the hours you actually get deeper, more restorative, and more efficient. Even if you have a kid in your bed. Even if you are perimenopausal and running hot. Even if you have been broken for years. I share the exact protein-before-bed hack that ended my 3 AM wake-ups, the caffeine half-life math (why your 2 PM coffee is still in your system at 10 PM), why I do not recommend melatonin for most women, the 3 sleep peptides I trust the most (DSIP,...
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The Complete Perimenopause Protocol: Peptides, HRT, Labs, Nutrition, Workouts & Supplements That Actually Work | Her Stack Series
Biohacking with Brittany
Perimenopause is not a slow fade. It is a hormonal storm that lasts about a decade. Estrogen swings, progesterone slips first, testosterone quietly declines, and growth hormone falls alongside all of it. That is why the workout that worked at 25 stops working at 45. It is why women come to me saying "I am doing everything right and the scale will not budge." Your biology is changing, and your approach has to change with it. In this episode I'm giving you my top recommendations for every pillar so you walk away with a real protocol, not a pile of overwhelm. We cover the exact biomarker labs to...
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Q&A: Where Would We Raise Our Family in Central America?, Wolverine Blend vs. Singles, Selank Peptide vs. Psilocybin & GHK-Cu Body Cream
Biohacking with Brittany
This week is a Q&A episode in two parts. In Part 1, I give you the honest, real-numbers breakdown of the four Central American countries we keep weighing for our family: Nicaragua, Costa Rica, Panama, and Mexico. Rent, nannies, food, healthcare, schools, and flights from Canada. In Part 2, I answer three of the peptide questions you sent me: the Wolverine blend for an ACL tear, Selank vs psilocybin microdosing, and whether GHK-Cu actually works in a body cream. Join for women-specific guidance on peptides, hormones, and longevity. Timestamps: 04:00 - The four-country...
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Body Composition Protocol for Women: Peptides, Growth Hormone, Protein, GLP-1s & The Complete Metabolic Reset | Her Stack Series
Biohacking with Brittany
Your body after a baby was never a calorie problem. It is a metabolic one. In this Her Stack episode I am walking you through exactly how to restore your metabolism so body composition follows. The goal is not weight loss. The goal is metabolic restoration. Body comp is downstream. I am breaking down the four drivers that actually run body composition (insulin, thyroid, sleep, growth hormone), the four pillars to address them (nutrition, lifestyle, supplements, peptides), and the exact peptide sequencing for women. Plus my honest take on GLP-1s including semaglutide, tirzepatide, and...
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Q&A: Peptides for Breastfeeding, Postpartum Weight Loss, Cancer History & How to Build Your Stack | Her Stack Series
Biohacking with Brittany
In this Q&A episode of the Her Stack Series, I'm answering the peptide questions you're asking me every single day in my DMs and comments: → Can I take peptides while breastfeeding? → What if I have a personal or family history of cancer? → Why won't my postpartum belly fat budge, even when I'm doing everything "right"? → Blends vs. single peptides, which is right for me? → How do I build my own peptide stack without ending up on eight injections a day? I'm unfiltered in this one. I share why there will never be clinical trials on peptides during breastfeeding (and what...
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The Complete Maternal Mental Health Protocol: Peptides, Anxiety, Depression, Bioregulators and the Science of the Postpartum Brain | Her Stack Series
Biohacking with Brittany
In this Her Stack series episode, I open up about maternal mental health, postpartum anxiety, and the invisible biological load mothers carry long after the six-week checkup is over. This episode is not just for the newly postpartum mother. It is for the mother whose kids are four, eight, fifteen, and still asking herself why she does not feel like herself. I share why motherhood structurally changes the brain, hormones, and nervous system, and why so many mothers are left feeling anxious, foggy, depleted, or unlike themselves without ever being properly screened or supported. I walk you...
info_outlineMichelle Skaff shares how one “cellular biohack” pulled her out of chronic pain, and why she believes oxidative stress is the quiet root of aging, inflammation, and so many chronic issues.
We talk antioxidant enzymes in plain English, why most supplements don’t solve oxidative stress at the source, and how community + purpose can be as health-changing as any protocol.
WE TALK ABOUT:
04:40 - What NRF2 is and how it helps reduce oxidative stress at the cellular level
10:10 - Understanding SOD (superoxide dismutase) and why antioxidant enzymes matter for aging
12:35 - Explaining oxidative stress with the “apple browning” analogy
15:35 - Why the same intervention works differently at 20 vs 80
17:40 - Using the “cellular traffic lights” framework (NRF2, mitochondria, NAD)
20:30 - Connecting oxidative stress to inflammation and aging hallmarks
28:30 - Debunking the “it’s just aging” myth behind joint pain
31:35 - Building a simple good/better/best starting stack for inflammation + joints
37:10 - Testing gut health and why Tiny Health stood out
42:35 - Why community and purpose are emerging longevity tools
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