403: Ophira Eisenberg and Picking Weird Things

Ophira Eisenberg! Comedian! Writer! Story-teller! Host! Friend! Delight! More!

Ophira is taping her next 1-hour comedy special, produced by Lewis Black, at The Comedy Cellar on Nov 9, 2025 at 5pm and 7pm. 

You can follow me @ophirae everywhere except for TikTok where she is @ophiranyc.

We have a great chat! You can have a great listen!

Also, this is only the first HALF of our chat.
For part two, subscribe via Apple Podcasts OR merely click on over here to Patreon!

PS Below is more about Ophira, from the bio on her website. Enjoy that as well!

Ophira Eisenberg is a Canadian-born standup comedian, writer, and host. She hosted NPR’s comedy trivia show Ask Me Another for 9-years, where she interviewed and played silly games with hundreds of celebrities including Sir Patrick Stewart, Awkwafina, Rosie Perez, Yo-Yo Ma, Bob The Drag Queen, Nick Kroll, Chelsea Handler, Jim Gaffigan, Michael C. Hall, and so many others.

As a comic and a parent to a 6-year-old, Ophira is the host of the new comedy podcast Parenting Is A Joke co-produced by iHeart Radio and Pretty Good Friends Productions. The show launches on October 18th.

She can be seen live, regularly headlining across the United States, Canada, and Europe delivering her unique blend of standup and storytelling to a loyal fan base of smart, irreverent comedy lovers. She has appeared at Montreal’s Just for Laughs Festival, The New Yorker Festival, The New York Comedy Festival, Moontower Comedy Festival, Bumbershoot, The Nantucket Film Festival, Women in Comedy Festival and more.

Her new comedy album at special Plant-Based Jokes is available on iTunes and is streaming now on YouTube. Lauded as “hilarious, high risk, and an inspiration,” Ophira filmed her comedy special Inside Joke, when she was 8½ months pregnant. The show’s material revolves around how she told everyone that she was never going to have kids, and then unexpectedly found herself expecting at “an advanced maternal age.” Her other comedy albums, Bangs! and As Is

She has appeared on Comedy Central, This Week at The Comedy Cellar, Kevin Hart’s LOL Network, HBO’s Girls, Gotham Live, The Late Late Show, The Today Show, and VH-1. The New York Times called her a skilled comedian and storyteller with “bleakly stylish” humor. She was also selected as one of New York Magazine’s “Top 10 Comics that Funny People Find Funny,” and hailed by Forbes.com as one of the most engaging comics working today. 

Ophira is a regular host and teller with The Moth and her stories have been featured on The Moth Radio Hour and in two of The Moth’s best-selling collections, including the most recent New York Times Bestseller: How To Tell A Story: The Essential Guide to Memorable Storytelling from The Moth. 

Ophira’s first book, Screw Everyone: Sleeping My Way to Monogamy (Seal Press), is a comedic memoir about her experiments in the field as a single woman, traveling from futon to futon and flask-to-flask, gathering data, hoping to put it all together and build her own perfect Frankenmate. It was optioned for a feature film. 

She is also sought after as a brilliant interviewer and moderator, and has interviewed dozens of celebrities, writers, and actors including Neil Gaiman at New York’s Town Hall; Jane Curtain, Anne Beatts, Heather Gardner, Sudi Green, Alysia Reiner, Jeanne Tripplehorn, David Crane, Jeffrey Klerik at The Nantucket Film Festival; Eugene Levy, Catherine O’Hara, Daniel Levy and Annie Murphy at the 92nd Street Y; and Nell Scovell and Sloane Crosley at The Mark Twain House. 

Originally from Calgary, Alberta, Canada, Ophira graduated with a Cultural Anthropology and Theater degree from McGill University. She now lives in Brooklyn, NY where she is a fixture at New York City’s comedy clubs including the Comedy Cellar, Gotham Comedy Club, New York Comedy Club and Carolines, as well as Brooklyn’s famed performance venues The Bell House, Union Hall, and Littlefield. She resides with her husband and son where she can regularly be seen drinking a ton of coffee.