149: Laurie Adami survived follicular non-Hodgkin Lymphoma | Yescarta CAR-T Therapy | Bexxar | Gazvya
Release Date: 07/30/2025
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Laurie Adami seemed to have it all. She was the president of her company, at age 40, she had just had a son and still found time to lead an active lifestyle. However, in 2003, her health took a turn for the worse. She felt a lump in her abdomen, experienced frequent, lengthy sinus infections and chronic fatigue. All this led to a diagnosis of Stage IV Follicular Non-Hodgkin Lymphoma. After six unsuccessful treatment regimens, she achieved complete remission on the seventh try, completing a battle that ran twelve years. When Laurie initially brought her...
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info_outlineLaurie Adami seemed to have it all. She was the president of her company, at age 40, she had just had a son and still found time to lead an active lifestyle. However, in 2003, her health took a turn for the worse. She felt a lump in her abdomen, experienced frequent, lengthy sinus infections and chronic fatigue. All this led to a diagnosis of Stage IV Follicular Non-Hodgkin Lymphoma. After six unsuccessful treatment regimens, she achieved complete remission on the seventh try, completing a battle that ran twelve years.
When Laurie initially brought her symptoms to the attention of her family doctor, they were dismissed as, at worst, a hernia, and exhaustion due to her demanding schedule; but Laurie insisted there was nothing ordinary about her symptoms and changed doctors.
She saw a hernia specialist who ordered a CT scan, which revealed a mass the size of a small watermelon on her abdomen. After a biopsy, Laurie learned she had Stage IV Follicular Non-Hodgkin Lymphoma. At that time, she had no idea of the difficulty and length of the journey awaiting her.
The first of six treatments that failed to overcome her diagnosis was in 2006 and called R-CHOP. It was a mix of Rituxan plus Cytoxan, Adriamyacin and Prednisone.
Next in 2008 was a clinical trial of Rituxan, along with an HDAC inhibitor.
In 2010, Laurie tried Bendamustin, a medication popular in Eastern Europe.
When that didn’t work, later in the year, she went with Bexxar Radioimmunotherapy.
Of the first six regimens, Laurie had the most success with a pi3 kinase inhibitor called Zydelig. For five and a half years ending in 2016, it shrunk the tumor without eliminating it.
The tumor returned and for six months ending in September 2017, she tried infusions of Gazvya.
On July 16, 2018, her tumor was still around, but Laurie qualified for a Phase II clinical trial of Yescarta CAR-T therapy. Some 29 days later, her lymphoma specialist informed her she was in full remission.
Laurie Adami has resumed an active lifestyle, and does plenty of traveling, most of it to public speaking engagements, as she serves as an advocate for the Leukemia & Lymphoma Society.
Additional Resources:
Support Group:
The Leukemia & Lymphoma Society https://www.lls.org