How Cryocompression is Fast Becoming the Future of CIPN Treatment
Release Date: 04/12/2023
What’s Next? The Future of Scalp Cooling Trials and Research
Changing the Face of Cancer
"We need more peer to peer sharing through conferences and grand rounds. We need to look at research into increasing efficacy in under-served populations, different head shapes, and anthracyclines." Richard Paxman sits down with oncology thought leaders and renowned clinical trial experts, to review scalp cooling trial data and results from the past decade, and consider what needs to be looked at next to improve efficacy within under-served populations. The group argue that scalp cooling tolerability and efficacy is well established and now is the time to look at more specific...
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Why Equity Matters in Cancer Care
Changing the Face of Cancer
"Always offer, it is up to patient to figure out whether or not they can afford something, and not up to us to assume whether they can afford something" Diversity and equity are currently high on the healthcare agenda - however there are still noticeable inconsistencies when it comes to side effect management in cancer care. Maimah Karmo, Founder of Tigerlily Foundation, sits down with oncologists and patient advocates to discuss why having appropriate individualized care is incredibly important for minority populations, with many chemotherapy side effects centred on skin...
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Back to Basics: Why Protocols are the KEY to Efficacious Side-Effect Management
Changing the Face of Cancer
"We talk to our patients a lot about being self-empowered – this is your opportunity to really self-manage this and take some responsibility in terms of the outcome." Dr Lindsay Peterson sits down with a multidisciplinary group of physicians, to discuss the wider picture surrounding protocols within chemotherapy side-effect management. They consider the often challenging integration of practices such as scalp cooling, and discuss their tried and tested approaches, detailed workflows, and the importance of interdisciplinary buy-in within their medical institutions, which has had a real impact...
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The Age of the Oncodermatologist: Championing Preventative Side-Effect Management
Changing the Face of Cancer
"Just about every single patient entering a cancer center who is likely to undergo treatment is a potential patient where an onco-dermatologist has a role" Dr Nicole LeBoeuf, Dr Beth McLellan, and Dr Ian Tattersall, have all chosen to specialise in the skin toxicity side effects of patient’s undergoing cancer treatment. In a discussion led by Dr Corina van den Hurk, they talk about being embedded within their respective oncology units, the side effects they witness daily affecting the skin, hair, and nails of patients receiving chemotherapy and radiation therapy, and the lasting impact this...
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The Clinicians Breaking Away from the ‘Taxanes Only’ Mentality
Changing the Face of Cancer
"Increased hair regrowth rates really was our pitch to help some of our oncologists who were less optimistic about scalp cooling with anthracyclines." Oncologist Dr Julie Nangia sits down with oncology thought leaders from Japan, Germany, and South Korea, to discuss what unites their cancer care practice – prescribing scalp cooling for patients on anthracycline regimens. Despite hair retention with scalp cooling on anthracycline regimens generally being lower in comparison to taxanes, the group discuss why having a ‘taxanes only’ mentality is limiting patient choice. They argue...
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How Cryocompression is Fast Becoming the Future of CIPN Treatment
Changing the Face of Cancer
"In using cryocompression to prevent CIPN, we have several advantages in terms that there is a huge need being driven by the patients themselves, and we have the physicians who are open to adopting newer technologies and try them out in clinical trials than there were a few years ago." Chemotherapy-induced peripheral neuropathy is an unseen, but lifelong and potentially debilitating chemotherapy side effect. With very few treatment interventions, prevention and reversal of CIPN has been largely unsuccessful to this point. Clinicians have witnessed patients using off the shelf cryotherapy...
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Why We Should Be Talking About the Psychosocial Impacts of Chemotherapy
Changing the Face of Cancer
"The changes are so rapid and so quick. The mental effects of hair loss is huge – the passion and the empathy from our clinicians is imperative." Professor Catherine Paterson sits down with Dr Amy Comander, RN Trisha Marsolini, Dr Eleonora Teplisnky, and patient advocate Asha Miller, to discuss why cancer treatment is not only physically challenging, but how the psychosocial side-effects of chemotherapy can send tidal waves through a patient’s life for many years. They discuss their own holistic approaches to patient-centred care, Maricia recounts where she felt the support was...
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Introducing: The Summit Series
Changing the Face of Cancer
For Season 2 of the podcast, you can hear some of the best bits from our Summit Series. Launches 29th March 2023. For more visit
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Managing hair loss in a metastatic setting: Investigating scalp cooling with Enhertu | Elahe Salehi DNP
Changing the Face of Cancer
In this episode, Rich sits down with Elahe Salehi, who is involved in the ground-breaking clinical trial currently being carried out at the Dana Farber Cancer Institute, comparing hair retention rates with scalp cooling in the metastatic setting. The chemotherapy drug regimens in question are Sacituzumab govitecan, Eribulin, and the highly anticipated Trastuzumab deruxtecan, also known as Enhertu. They discuss the motivations behind the trial and its design, and the outcome measures decided upon which look closely at the impact on patient quality of life. They also ask, why is it that...
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Getting Involved in the International Scalp Cooling Registry
Changing the Face of Cancer
In this bonus episode, Corina van den Hurk of the Netherlands Comprehensive Cancer Organisation discusses the expansion of the Dutch Scalp Cooling Registry to include international data, following the success of the database of over 7,000 Dutch patients scalp cooling results, which has provided a vital insight into scalp cooling efficacy. Maryam Lustberg, Chief of Breast at Yale Cancer Centre, also expresses her support for the registry, as it continues to drive the movement towards precision symptom management within cancer care. As well as providing an insight on how Corina and her team are...
info_outline"In using cryocompression to prevent CIPN, we have several advantages in terms that there is a huge need being driven by the patients themselves, and we have the physicians who are open to adopting newer technologies and try them out in clinical trials than there were a few years ago."
Chemotherapy-induced peripheral neuropathy is an unseen, but lifelong and potentially debilitating chemotherapy side effect. With very few treatment interventions, prevention and reversal of CIPN has been largely unsuccessful to this point. Clinicians have witnessed patients using off the shelf cryotherapy options, but they are unmeasured, untested, and often ineffective.
Dr Charles Loprizini sits down with oncologists and researchers to discuss what we already know about CIPN’ its impact on physical and psychological quality of life, and why the development of a new cryocompression device is showing real promise in preventing the condition as the next stage of trials begins.
Shownotes:
- Loprinzi C, et al. Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update. Journal of Clinical Oncology 2020 38:28, 3325-3348
- Jordan B, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO-EONS-EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct;31(10):1306-1319.
- Kanbayashi Y, et al. Comparison of the efficacy of cryotherapy and compression therapy for preventing nanoparticle albumin-bound paclitaxel-induced peripheral neuropathy: A prospective self-controlled trial. Breast. 2020 Feb;49:219-224.
- Shigematsu H, et al. Cryotherapy for the prevention of weekly paclitaxel-induced peripheral adverse events in breast cancer patients. Support Care Cancer. 2020 Oct;28(10):5005-5011.
- Schmid P et al. Pembrolizumab for Early Triple-Negative Breast Cancer. N Engl J Med 2020; 382:810-821.
- Filter by ‘Chemotherapy Side Effect’ on the Scalp Cooling Studies Website for more clinical studies on the use of cryotherapy for CIPN: www.scalpcoolingstudies.com