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In the News... Infusion set recall, diabetes & sleep studies, cinnamon clinical trial and more!

Diabetes Connections | Type 1 Diabetes

Release Date: 12/01/2023

Schools are still pushing back on CGM. How you can help the legal fight for change show art Schools are still pushing back on CGM. How you can help the legal fight for change

Diabetes Connections | Type 1 Diabetes

Earlier this year, it looked like a big win for parents of kids with diabetes when the DOJ ruled that CGM can be considered standard of care.  Unfortunately, the lawyers fighting for families in this case tell me it’s not that simple, the Dept of Justice ruling may have to be litigated on the local levels across the country. They’re back to talk to me about what happened, what you need to know, and how you can make your issue known, if your child’s school is giving you a hard time about continuous glucose monitoring. Our guests this week are Bonnie Roswig, an attorney with a small...

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In the News... Hurricane aid, Medtronic recall, Mounjaro supply update, stem cell T1D success... and more! show art In the News... Hurricane aid, Medtronic recall, Mounjaro supply update, stem cell T1D success... and more!

Diabetes Connections | Type 1 Diabetes

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: Hurricane aid for people with diabetes, Medtronic safety warning, stem cell updates for type 1, new study about teens and young adults with type 1, and Ryan Reed returns to racing. Find out more about  Please visit our Sponsors & Partners - they help make the show possible! Learn more about   from extreme temperatures Learn more about  Drive  The best way to keep up with Stacey and the show is by signing up for our weekly newsletter:...

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Mental Health and T1D –  Support & Advice from a Passionate Endo show art Mental Health and T1D – Support & Advice from a Passionate Endo

Diabetes Connections | Type 1 Diabetes

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Testing for T1D has changed - what you (and your doctor) need to know about screening show art Testing for T1D has changed - what you (and your doctor) need to know about screening

Diabetes Connections | Type 1 Diabetes

We’ve been hearing a lot more about screening for type 1 diabetes – I saw my first mainstream commercial for it last week – but what does that mean? If you have type 1 or you have a child with T1D, are you thinking about screening other family members? Should you? Over the summer new guidelines were announced for health care providers – including mental health guidelines. There’s a lot to unpack here.. my guest is the director of community screening and clinical trials education with BT1D. My guest this week is Anastasia Albanese-O'Neill, the director of community screening and...

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In the News... Insulin price lawsuit, new CGM approved, diabetes camp scholarships... and more! show art In the News... Insulin price lawsuit, new CGM approved, diabetes camp scholarships... and more!

Diabetes Connections | Type 1 Diabetes

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How How "Accidental Demons" author Clare Edge keeps diabetes real, even in a fantasy novel

Diabetes Connections | Type 1 Diabetes

Clare Edge says “Diabetes is the least interesting thing about me, I don't actually like talking about it.” But she also wrote a fantastic new book all about – diabetic witch. The main character of "Accidental Demons" is a middle school aged witch with type 1 who can’t stop conjuring when she pricks her finger. We’ll talk about the book, Clare’s story of finding her way in the diabetes community, fighting the pursuit of perfection, and a lot more. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Learn ...

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A new era of CGM? Dexcom’s Jake Leach on Stelo, G7 updates and more. show art A new era of CGM? Dexcom’s Jake Leach on Stelo, G7 updates and more.

Diabetes Connections | Type 1 Diabetes

For the first time, you can buy a continuous glucose monitor over the counter, no prescription needed. This summer we went from no CGMs available this way, to now having two. This week we’re talking about the Dexcom Stelo with the company’s COO Jake Leach. We’ll talk about Stelo and get an update on G7 features including Dexcom’s plans to address concerns over Geofencing, and issues that can potentially arise if you travel outside your home country. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider. Please...

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In the News... CGM in space, diet and type 1 diabetes study, GLP-1 gel in development, and more! show art In the News... CGM in space, diet and type 1 diabetes study, GLP-1 gel in development, and more!

Diabetes Connections | Type 1 Diabetes

It’s In the News! A look at the top diabetes stories and headlines happening now. Top stories this week: Dexcom CGM is worn in space, two over-the-counter CGMs are now available, a large new study looks at potential dietary causes of type 1, and researchers are looking at a gel version of GLP-1 medications. Find out more about  Please visit our Sponsors & Partners - they help make the show possible! Learn more about   from extreme temperatures Learn more about  Drive  The best way to keep up with Stacey and the show is by signing up for our...

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Making it to the Big Leagues with T1D: Minnesota Twins draft pick Jaime Ferrer show art Making it to the Big Leagues with T1D: Minnesota Twins draft pick Jaime Ferrer

Diabetes Connections | Type 1 Diabetes

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Travel Alert: What You Need to Know About Geofencing and Dexcom G7 show art Travel Alert: What You Need to Know About Geofencing and Dexcom G7

Diabetes Connections | Type 1 Diabetes

Traveling with diabetes gives you enough to think about – especially traveling internationally: preparing, packing, going through airport security. But if you travel out of your country – not just the US – with your Dexcom G7, you also have to be aware of something called geofencing. If something goes wrong with your phone or your app.. getting it back is going to be an issue. We’ll talk about how this works, why it’s in place, and what you can do about it. This podcast is not intended as medical advice. If you have those kinds of questions, please contact your health care provider....

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More Episodes

It’s In the News, a look at the top stories and headlines from the diabetes community happening now. Top stories this week: infusion set recall, update on ViaCyte stem cell research, a few new studies look at sleep and diabetes, actual clinical research into cinnamon for type 1 and lots more.

Links & transcript below

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Episode transcript:

Hello and welcome to Diabetes Connections In the News! I’m Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now.

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In the news is brought to you by Edgepark simplify your diabetes journey with Edgepark

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Our top story this week…

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A recall of infusion sets. This is the VariSoft infusion set used with Tandem Diabetes Pumps. The recall here isn’t new.. but the FDA has changed the rating to Class 1, its most serious. The VariSoft version is flexible and can be put in place at an insertion angle anywhere between 20 and 45 degrees, it’s usually recommended for people “who are thin or who have scar tissue or limiting potential insertion sites.”

The problem is that the connector can detach from the set – which means no insulin is going in. To date, according to the FDA notice, there has only been one report of injury related to the recall.

https://www.fiercebiotech.com/medtech/fda-gives-class-i-recall-rating-infusion-sets-used-tandem-insulin-pumps

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An already existing drug may help preserve beta cell function in people with new onset type 1. It’s got a very long name, so it’s usually referred to as DFMO.  It inhibits a pathway, which plays a role in the inflammatory responses in autoimmune diseases, including type 1 diabetes. It's sold under a few names for different conditions, including Vaniqa which is a cream for unwanted hair growth in women. It also has orphan designations for treating various cancers, including neuroblastoma.

The new safety study by Sims and colleagues, which was published November 1 in Cell Medicine Reports, enrolled 41 people with type 1 diabetes that had been diagnosed within the previous 8 months, including 31 children. Participants were randomly assigned to undergo oral treatment with DFMO at one of five doses or placebo for 3 months, with 3 additional months of follow-up.

Following a mixed-meal tolerance test at 6 months, the C-peptide area under the curve ― a measure of beta-cell function ― was significantly higher with the three highest DFMO doses compared to placebo (P = .02, .03, and .02 for 125 mg/m2, 750 mg/m2, and 1000 mg/m2, respectively).

https://www.medscape.com/viewarticle/998671?form=fpf

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Despite earlier promising findings, it seems unlikely that cinnamon can improve blood sugar levels in people with type 1, or insulin-dependent, diabetes, researchers report.

Previous research has shown that cinnamon appears to help fat cells recognize and respond to insulin. In test tube experiments and in animal studies, the spice led to a noteworthy increase in the processing of glucose. Moreover, in a previous study of people with type 2, or non-insulin dependent, diabetes, those who incorporated a small amount of cinnamon each day for 40 days into their normal diets experienced a healthy drop in blood sugar levels.

But a new study of teenagers with type 1 showed cinnamon made no difference after 90 days .

In fact, "In essentially all outcomes...the trend favored the placebo group, although did not achieve statistical significance," the researchers report.

 

https://www.reuters.com/article/us-cinnamon-diabetes-idUSSIB65463020070406/

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New results from ViaCyte clinical trials – that’s a stem cell-based treatment for type 1 diabetes.  The therapy aims to replace the insulin-producing beta cells that people with type 1 diabetes lack. Dubbed VC-02, the small medical implant contains millions of lab-grown pancreatic islet cells, including beta cells. The devices—approximately the size of a Band-Aid and no thicker than a credit card—are implanted just beneath a patient's skin where it is hoped they will provide a steady, long-term regulated supply of self-sustaining insulin. The clinical trial was conducted at Vancouver General Hospital, with additional sites in Belgium and the U.S. Ten participants, each of whom had no detectable insulin production at the start of the study, underwent surgery to receive up to 10 device implants each.

 

Six months later, three participants showed significant markers of insulin production and maintained those levels throughout the remainder of the year-long study. These participants spent more time in an optimal blood glucose range and reduced their intake of externally administered insulin.

 

One participant, in particular, showed remarkable improvement, with time spent in the target blood glucose range increasing from 55% to 85%, and a 44% reduction in their daily insulin administration.

 

In another ongoing trial, the UBC-VCH team is investigating whether a version of the device containing cells that have been genetically engineered to evade the immune system, using CRISPR gene-editing technology, could eliminate the need for participants to take immunosuppressant drugs alongside the treatment.

https://medicalxpress.com/news/2023-11-stem-cell-based-treatment-blood-sugar.html

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A new look at sleep quality in people with type 1 finding that more time in range means better sleep. No surprise here, but important to quantify. Interestingly, recurrent high or low blood sugar, rather than constant or prolonged higher levels seems associated with worse sleep.

A study in adults with type 1 diabetes showed that 17.7% wake up every night, and 53.5% wake up once or twice a week1. This was a small pilot study – the researchers want to now move to a larger one.

https://www.nature.com/articles/s41598-023-47351-x

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New study looks at women, sleep and insulin sensitivity. This is a small study, only 40 women, which found that particularly post menopausal women who sleep less 7 hours per night may have impaired insulin sensitivity regardless of body fat.

Nearly 40 women were randomly assigned to either restricted sleep or adequate sleep for 6 weeks, then crossed over to the other sleep condition. During sleep restriction, women slept an average of 6.2 hours per night vs 7-9 hours per night. Both fasting insulin levels and insulin resistance were significantly increased during sleep restriction with more insulin needed to normalize glucose. These researchers say if sustained over time, it is possible that prolonged insufficient sleep among individuals with prediabetes could accelerate the progression to type 2 diabetes

https://www.medscape.com/viewarticle/insufficient-sleep-impairs-womens-insulin-sensitivity-2023a1000tlz

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Pregnant women with type 2 who use CGM saw improvement in blood glucose levels but only if they used the device more than 50% of the time during their pregnancy. This study involved high-risk women from regional and remote Australia all with type 2. No changes in diabetes metrics were seen in those who used the CGM only early or late in their pregnancies.

https://www.healio.com/news/endocrinology/20231128/greater-use-of-cgm-linked-to-glycemic-benefits-for-pregnant-women-with-type-2-diabetes

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Commercial

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When it comes to walking and type 2 diabetes risk, it’s not just how much you do it that helps — it’s also how fast you move, a new study has found.

 

Brisk walking is associated with a nearly 40% lower risk of developing type 2 diabetes later in life, according to the study published Tuesday in the British Journal of Sports Medicine.

 

“Previous studies have indicated that frequent walking was associated with a lower risk of developing type 2 diabetes in the general population, in a way that those with more time spent walking per day were at a lower risk,” said the study’s lead author Dr. Ahmad Jayedi, a research assistant at the Social Determinants of Health Research Center at the Semnan University of Medical Sciences in Iran.

The study authors reviewed 10 previous studies conducted between 1999 and 2022, which assessed links between walking speed — measured by objective timed tests or subjective reports from participants — and the development of type 2 diabetes among adults from the United States, the United Kingdom and Japan.

 

After a follow-up period of eight years on average, compared with easy or casual walking those who walked an average or normal pace had a 15% lower risk of developing type 2 diabetes, the researchers found. Walking at a “fairly brisk” pace meant a 24% lower risk than those who easily or casually walked. And “brisk/striding walking had the biggest benefit: a 39% reduction in risk.

Easy or casual walking was defined as less than 2 miles per hour. Average or normal pace was defined as 2 to 3 miles per hour. A “fairly brisk” pace was 3 to 4 miles per hour. And “brisk/striding walking” was more than 4 per hour. Each kilometer increase in walking speed above brisk was associated with a 9% lower risk of developing the disease.

https://www.cnn.com/2023/11/28/health/walking-speed-lowers-diabetes-risk-wellness/index.html

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Not a lot of events happening in December but there are two to tell you about:

Beyond Type 2 virtual summit

https://beyondtype2.org/registration-type-2-diabetes-virtual-summit/