Transthyretin Cardiac Amyloid: 'Dr RR Baliga's "Got Knowledge Doc" Podcasts
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Release Date: 02/07/2024
Vitamin B12: The Brain & Blood Booster? 🩸🧠💪
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Vitamin B12: Essential for Health 🩸🧠 Vitamin B12 is crucial for red blood cell formation, brain function, and DNA synthesis. Found in animal-based foods 🥛🍳🐟, those on vegan diets need fortified foods or supplements 💊. Deficiency can cause anemia, neurological issues, and cognitive decline ⚠️. High-risk groups include vegans, vegetarians, older adults, and individuals with malabsorption conditions 🏥. Maternal deficiency affects fetal development 🤰👶. Absorption declines with age, and severe cases (e.g., pernicious anemia) may require high-dose supplements or...
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☀️ Vitamin D: The Sunshine Nutrient for Strong Bones & Immunity? 🦴🛡️”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Vitamin D is essential for bone health 🦴, immune function 🛡️, and muscle strength 🏋️. Deficiency is common and affects women 👩⚕️, young adults 🧑🎓, and non-Hispanic Black Americans. Main sources include sunlight ☀️, oily fish 🐟, eggs 🥚, and fortified foods 🥛. Recommended intake is 600-800 IU/day 💊. Studies show mixed results 📊, but it may help with cancer prevention 🎗️, autoimmune diseases 🧬, and cognitive function 🧠. Excessive intake ⚠️ can cause kidney stones 🩺 and hypercalcemia.
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🔥 Vitamin D & Multiple Sclerosis: Defending the Nervous System 🧠🛡️
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧠 High-dose Vitamin D (100,000 IU biweekly) reduced disease activity in Clinically Isolated Syndrome (CIS) of MS 🌞📉. Patients had fewer MRI lesions 🖥️, longer time to disease activity ⏳, but no significant impact on relapses ❌. Well-tolerated with minimal side effects ⚕️, These findings support further research on Vitamin D as an MS therapy 🔬🚀.
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BEAM-302: Rewriting Genes, Restoring Health – A Breakthrough in AATD Therapy! 🔬🚀
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🔬 BEAM-302 is a liver-targeting gene therapy using base editing to correct the PiZ mutation in Alpha-1 Antitrypsin Deficiency (AATD). 🧬 I t increases functional AAT 🫁 while reducing toxic Z-AAT, showing up to 78% reduction at the 60 mg dose. 📊 The Phase 1/2 trial demonstrated dose-dependent efficacy, a well-tolerated safety profile, and no serious adverse events (SAEs). 🛡️ With ongoing dose escalation and expansion to liver disease patients, BEAM-302 could be a one-time curative therapy 🚀, with further data expected in late 2025. 📅
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Dr. RR Baliga’s Philosophical Discourses: Confucius (China, 551–479 BCE) – Founder of Confucianism
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Confucius (c. 551–479 BCE), a renowned Chinese philosopher and teacher, founded Confucianism, emphasizing morality, family loyalty, social harmony, and virtuous governance. His teachings, compiled in the Analects, profoundly influenced Chinese culture, ethics, and education.
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“The Brain’s Switchboard 🔄: How MRN Controls Perseverance 🛑, Exploration 🚀 & Disengagement ❌”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
This study identifies the Median Raphe Nucleus (MRN) 🧠 as a behavioral switchboard 🔄, regulating perseverance 🛑, exploration 🚀, and disengagement ❌ through distinct neuron types. GABAergic neurons 🟢 promote perseverance, Glutamatergic neurons 🔵 drive exploration, and Serotonergic neurons 🟠 maintain engagement. Using optogenetics 💡, fiber photometry 📈, and circuit tracing 🔗, researchers demonstrated how MRN integrates signals from the lateral hypothalamus (LHA) 🌟 and lateral habenula (LHb) ⚡ to control decision-making. These findings have clinical...
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“💊 High Intensity Statins vs Smart Alternatives: A Heart-Healthy Showdown! ❤️📉”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🔬 Study Overview: A meta-analysis comparing alternative LDL cholesterol-lowering strategies (moderate-intensity statins + ezetimibe) vs high-intensity statins in patients with ASCVD. 📊 Key Findings: ✅ No significant difference in 3-year cardiovascular events (7.5% vs 7.7%) 📉 Lower LDL cholesterol in the alternative strategy (64.8 vs 68.5 mg/dL) 🩸 Reduced risk of new-onset diabetes (10.2% vs 11.9%) 💊 Fewer therapy discontinuations due to intolerance (4.0% vs 6.7%) ⚖️ Conclusion: The alternative strategy offers comparable efficacy with better tolerability and...
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“Stronger Bones, Fewer Fractures! 🦴🔍 USPSTF Osteoporosis Screening Guide”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🦴 USPSTF Osteoporosis Screening Summary 📋 🔍 Why? Prevent fractures, disability, and mortality. 👩⚕️ Who? Women 65+ ✅, at-risk postmenopausal women ✅, men ❌ (insufficient evidence). 🩻 How? DXA scan (bone density test) is the gold standard. ⚠️ Risk Factors: Age, low weight, family history, smoking, alcohol, medications. ✅ Benefits: Reduces fracture risk with moderate evidence. ⚠️ Harms: Minimal risks, rare side effects from treatment. 📌 Takeaway: Screen women 65+ and younger high-risk women!
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“🫀 Cracking the Calcium Code: How CAC Scoring Transforms Cardiovascular Risk Assessment! 🔬📊”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🫀 Cardiac CT Calcium Score: Key Insights 🔬📊 🔍 What is CAC? ✅ Measures calcified plaque in coronary arteries via cardiac CT 📸 ✅ Higher CAC = Higher cardiovascular risk ⚠️ ✅ Agatston Score: 0 (None) → >400 (Severe Atherosclerosis) 📊 Clinical Impact: ✅ Strong predictor of ASCVD events (MI, stroke, CHD death) 📉 ✅ MESA Study: CAC >300 → 10-year CHD risk: 13-25% ✅ CAC = 0 → Low risk, even for some statin-eligible patients 🚀 🎯 Guidelines & Utility: 📢 Used for risk stratification in intermediate-risk patients (7.5%-20%...
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Tirzepatide: Game Changer for Weight Maintenance 💊📉
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Tirzepatide & Weight Maintenance 💊📉 A phase 3 clinical trial (SURMOUNT-4) showed that continued use of tirzepatide helps maintain weight loss in adults with obesity. Participants on tirzepatide lost an extra 5.5%, while those on placebo regained 14%. ✅ 89.5% maintained at least 80% of their weight loss, compared to 16.6% on placebo. Common side effects were mild gastrointestinal issues 🤢. Stopping treatment led to significant weight regain, reinforcing the need for long-term therapy. 🔬
info_outline🎧 Transthyretin (TTR) Amyloid: Dr RR Baliga "Got Knowledge Doc" PodKast for Physicians
1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935
2. Treatment of Cardiac Transthyretin Amyloidosis: Emdin M, Aimo A, Rapezzi C, et al. An Update. Eur Heart J 2019;40:3699-3706.
3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC
Transthyretin (TTR) Amyloid: "Hot-off-the-Press Dr RR Baliga MUST KNOW FACTS PodKast"
1. Association of the V122I Hereditary Transthyretin Amyloidosis Genetic Variant With Heart Failure Among Individuals of African or Hispanic/Latino Ancestry Scott M. Damrauer, MD; Kumardeep Chaudhary, PhD; Judy H. Cho, MD; et al. JAMA. Dec10th, 2019;322(22):2191-2202. doi:10.1001/jama.2019.17935
2. Treatment of Cardiac Transthyretin Amyloidosis: An Update. Eur Heart J 2019;40:3699-3706.
3. Treatment of Cardiac Transthyretin Amyloidosis Dec 13, 2019 | RR. Baliga, MD, FACC