💥 Old Drugs, New Power: Amiloride vs Spironolactone in Resistant Hypertension
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🩺 New hope for #ResistantHypertension! A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉 Fewer side effects, similar BP drop! But spironolactone may still reign 👑 for organ protection 🫀🧠 🧪 #Hypertension #Cardiology #JAMA2025
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🧪 Precision for One, Promise for Many: CRISPR Meets the Clinic--A New Era in Rare Disease Therapy
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀 Ammonia levels down, no hospitalizations, and hope up. N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDisease
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🔥 Smoldering Systems: Staging Systemic Metabolic Disorder Before It Ignites
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New framework alert! Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬 From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯 #MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊
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Dr RR Baliga's Philosophical Discourses: Pyrrho (Greece, c. 360–270 BCE) – Founder of Pyrrhonism
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism. He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind). Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by refraining from beliefs, one could achieve tranquility. His teachings laid the foundation for later skeptical thought in philosophy and medicine.
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🧬 Target ANGPTL3, Tame the Lipids, Transform the Risk
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬 New hope for lipid warriors! Solbinsiran (siRNA) slashed apoB 🩸, TGs 🍟, LDL-C 💔 & liver fat 🫀 in just 205 pts with mixed dyslipidaemia. Safe ✅ Durable ✅ Quarterly dosing? Maybe ✅ Let’s talk outcomes! 🎯 #PROLONGANG3 #RNAtherapy #CardioTwitter #LipidLowering
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🏥 Watch, Wait, or Wage War? The Prostate Cancer Playbook
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧔♂️ Prostate cancer is the most common cancer in US men. 🧪 PSA testing? 🔍 It’s all about shared decision-making. 🧬 From Gleason scores to PSMA-PET, precision reigns. 💉 ARPIs & ADT = survival gains in advanced disease. ⚖️ Screen smart. Treat right. Save lives. #ProstateCancer #MensHealth #Oncology 🧠💪
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Triglycerides, Trials, and Triumph 🚧📉🏆: The ANGPTL4 Story
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New frontier in lipid-lowering! 🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50% 🛡️ Safe, well-tolerated, no lymph node issues 💡 Promising for residual ASCVD risk Next step? Big trials, big answers! 📊🫀 #LipidScience #CardioTwitter #PrecisionMedicine
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Cracking the Code of Short Sleepers 🧠🔍😴
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Why do some people sleep just 4 hours and feel great? 😴💪 A new study links the 🧬 SIK3-N783Y mutation to natural short sleep! Less sleep, more delta power 🧠⚡ 🚀🛌 #SleepScience #Genetics #SIK3 #ShortSleepers
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🔥 IL-6, Inflammation, and Irregular Beats: The Cytokine Cascade Driving Post-Op AFib
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🫀 Post-op AFib? Blame IL-6! New @JClinInvest study shows IL-6 ➡️ STAT3 ➡️ CaMKII ➡️ RyR2 leak triggers post-op AFib. 🧬 Macrophage IL-6Rα is the match. 🧯 TTI-101 & KN-93 douse the flame. ⚡ Targeting IL-6 signaling = future Rx? #CardioTwitter #AFib #Inflammation #JCI
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Good Carbs, Great Life, Golden Years 🥦✨👵
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🥦🍎 Want to age like fine wine? Choose high-quality carbs! In a 32-year study of 47K women, fiber-rich carbs (from 🌾, 🥗, 🌱) boosted odds of healthy aging 🧠💪🧘♀️ Refined carbs? Not so kind. #HealthyAging #NutritionMatters #WomensHealth 🧬📊💚
info_outlinePlato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle.
He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.