Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Cancer cachexia isn’t just weight loss—it’s a hijacking of motivation 😔. Elevated IL-6 🔥 activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine 💊 in the nucleus accumbens, leading to effort-based apathy 💤. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway 💡.
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“🧠 Fewer Strokes, 🚫 No Bleeds, ✅ Stronger Choice: Clopidogrel After PCI?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧪 SMART-CHOICE 3 in a Nutshell 🟣 Clopidogrel beat 🟠 aspirin post-PCI: 📉 Fewer MACCE (4.4% vs 6.6%) 🩸 Same bleeding risk 🍽️ Fewer GI events ⚠️ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. 🎯 Verdict: Promising—but not bulletproof.
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Mitochondria. Medicine. Miracles
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🔋 Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving 🫀 baby hearts to protecting 🧠 stroke-affected brains, this tiny powerhouse may revolutionize medicine—one cell at a time. 🧬💉✨
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Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.
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Mitochondria the Tiny Travelers, Big Impact, Bold Future
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬 Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells 🚀—healing neurons 🧠, boosting immunity 🛡️, and even aiding cancer cells ⚠️. Scientists are now exploring how to harness this dynamic dance for future therapies 💉.
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From Cold to Bold: The Legacy of Winter Conception
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
❄️ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. 🔬 Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 🧬 The key factor: Temperature and its diurnal variation before conception — not birth season — predicts adult brown adipose tissue (BAT) function. 📉 Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...
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“Heart on Fire? Timing Colchicine Right ⏳🧯🏥”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Colchicine 💊, once a humble gout remedy, is now reshaping coronary care 🫀. Trials show it reduces events in stable CAD ✅, but its benefit post-MI ⛑️ depends on timing ⏰. Inflammation matters — and so does when we strike. Colchicine in CAD: Small Pill, Big Debate 💊🔥🫀 An ancient anti-inflammatory has found new life in cardiology — reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. ⏰✨
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The Kilimanjaro Cure 🌋🥬:: 🧬: How Heritage Diets Heal
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🌿 Switching to a Western diet 🍔 increased inflammation 🔥 and metabolic dysfunction. 🍌 Mbege and traditional foods calmed the immune system 🧘 and boosted IL-10 🕊️.
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“Salted Truths: 🧂❤️⚖️ Rethinking Sodium for Heart and Kidney Health”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Not all salts are created equal! 🧂 Sodium chloride raises blood pressure and harms the heart 😈, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients 🛡️🫀. Chloride channels (CLICs) play a hidden but vital role in heart health 🔌❤️. We need large RCTs 🧪📊 to guide smarter, personalized salt strategies for better cardiovascular care 🎯🌍.
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💊 Oral Semaglutide Enters the Arena — The SOUL Trial
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
The SOUL trial 🧪 showed that oral semaglutide 💊 significantly reduced major cardiovascular events ❤️ (MACE) in people with type 2 diabetes 🩸 and ASCVD/CKD 🚑. Over ~4 years, it cut heart attacks 💥, lowered HbA1c 📉, reduced weight ⚖️, and inflammation 🔥 — all with a once-daily pill 🕊️ and no rise in serious side effects.
info_outline🚨 Air traffic controllers face severe fatigue due to the 2-2-1 shift system, causing sleep loss, cognitive impairment & safety risks. 🛑 FAA & NATCA now plan to replace it with a safer schedule to enhance aviation safety. ✈️ #Fatigue #AviationSafety #ATC
The 2-2-1 shift system in air traffic control (ATC) compresses five shifts into four days, leading to severe fatigue due to counterclockwise rotation and insufficient rest periods.
The FAA’s 2024 study found that this schedule causes sleep deprivation, cognitive impairment, and increased safety risks, with 77% of controllers unintentionally falling asleep on duty and 36% falling asleep while driving home.
The FAA and NATCA have now agreed to replace this system with a new schedule that prioritizes fatigue management and aviation safety through improved rest periods and scheduling practices.