๐ฌ Silence APOC3, Slash Triglycerides, A New Era in Triglyceride Control
Dr. Baliga's 'Podkasts for Curious Docs'
๐จ New NEJM Study on Olezarsen ๐จ In patients with moderate hypertriglyceridemia and elevated cardiovascular risk, monthly subcutaneous olezarsen reduced triglycerides by over 60% at 6 months! ๐๐ฅ โ Significant drops in APOC3, VLDL, remnant & non-HDL cholesterol โ No rise in LDL-C โ Well-tolerated with mild injection-site reactions ๐ฌ APOC3 inhibition emerges as a game-changer in lipidology. ๐ ESSENCEโTIMI 73b Trial | Funded by Ionis Pharmaceuticals #Cardiology #LipidLowering #PrecisionMedicine #NEJM #Olezarsen #TGlowering #CVRisk #TIMI...
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Dr RR Baliga's Philosophical Discourses: Dogen (Japan, 1200โ1253 CE) โ Founder of Soto Zen
Dr. Baliga's 'Podkasts for Curious Docs'
๐ธ Dลgen Zenji (1200โ1253), founder of the Sลtล Zen school in Japan, taught that true practice lies in zazenโโjust sittingโ ๐งโโ๏ธโwhere enlightenment and practice are inseparable. His Shลbลgenzล continues to inspire mindfulness & presence today. โณโจ #Zen #Mindfulness
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NSTEMI: ๐ Less Ischemia, Less Reintervention
Dr. Baliga's 'Podkasts for Curious Docs'
๐จ New Evidence in NSTEMI Care! ๐ซ The SLIM Trial shows that FFR-guided complete revascularization during the index procedure in patients with NSTEMI and multivessel disease significantly reduces death, MI, stroke, and repeat PCI compared to culprit-only PCI. ๐ฏ Key win? Fewer revascularizations, better outcomes โ physiology beats anatomy again. ๐ Published in JAMA, presented at #ESC2025 ๐ Read more: https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2025.16189 #Cardiology #NSTEMI #FFR #InterventionalCardiology #EvidenceBasedMedicine #SLIMTrial
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Real-World Rx ๐, Real Results ๐: GLP-1 Agents Slash HFpEF Risk
Dr. Baliga's 'Podkasts for Curious Docs'
๐ฅ Practice-Changing Evidence in HFpEF! ๐ฅ In a real-world cohort of 97,000+ patients with obesity & type 2 diabetes, semaglutide and tirzepatide reduced risk of heart failure hospitalization or death by over 40% ๐ โ๏ธ No meaningful difference between the two agents. ๐ง Findings reinforce STEP-HFpEF & SUMMIT trials and highlight GLP-1 therapiesโ expanding role in cardiometabolic HFpEF ๐ซ #Cardiology #HFpEF #GLP1 #Semaglutide #Tirzepatide #T2DM #RealWorldEvidence #JAMA #HeartFailure
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The AMALFI AF Screening Trial-๐ Atrial Fibrillation Unmasked: A Modest Win for Mailed Monitors
Dr. Baliga's 'Podkasts for Curious Docs'
๐ข Just read the #AMALFI trial in JAMA ๐ฐ โ a landmark remote RCT of AF screening using 14-day ECG patches mailed to older adults at stroke risk ๐ฆ๐ซ. At 2.5 years, the patch group had a modestly higher AF detection rate (6.8% vs 5.4%, p=0.03) and increased anticoagulation use ๐๐ง . Stroke rates were similar โ๏ธ. ๐ฏ Key takeaway: Remote, mail-based AF screening is feasible and nudges diagnosis rates โ but will it move the needle on outcomes? #AFib #StrokePrevention #RemoteMonitoring #ECG #Cardiology #RCT #JAMA #DigitalHealth #Geriatrics ๐ง๐
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๐ AFib Gone, OAC Gone? ALONE-AF Challenges Lifelong Therapy
Dr. Baliga's 'Podkasts for Curious Docs'
๐จ New Trial Alert ๐จ Can we safely stop anticoagulation after AF ablation? The ALONE-AF Trial ๐ซ suggests yesโin selected patients with no AF recurrence, stopping DOACs reduced major bleeding ๐ without increasing stroke risk ๐ง . ๐ 0.3% vs 2.2% for the composite outcome (P = .02) ๐ Carefully monitored, low-risk patients may benefit most. ๐ Editorial: Recommends shared decision-making ๐ค & individualized rhythm monitoring. ๐ A potential shift in post-ablation care. ๐ #AFib #Anticoagulation #EPTrials #CardioTwitter #StrokePrevention #JAMA...
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๐ฆ ๐Bugged After the Heartbreak? Does H. pylori Screening After MI Prevent GI Bleeds?
Dr. Baliga's 'Podkasts for Curious Docs'
๐จ New Findings from the HELP-MI Trial! ๐ธ๐ช๐งช Can routine Helicobacter pylori screening during acute myocardial infarction (MI) hospitalization prevent upper gastrointestinal bleeding (UGIB)? ๐ Over 18,000 patients across 35 Swedish hospitals ๐ Result: No significant reduction in UGIB overall (RR 0.90; P=0.18) ๐ BUT: Clear benefit in patients with anemia (RR 0.44โ0.64) and chronic kidney disease (RR 0.75) ๐ง Key Takeaway: Routine screening isnโt broadly warrantedโbut targeted testing in high-risk AMI patients may be the smarter path forward. ๐...
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๐งฌ Risk, Recurrence, Relief: Apixabanโs Edge in VTE ๐ก๏ธ Emphasizes the risk stratification, recurrence data, and therapeutic benefit
Dr. Baliga's 'Podkasts for Curious Docs'
๐ฉบ New Insights on Apixaban for VTE! ๐ข The HI-PRO trial challenges the old 3-month rule for provoked VTE. ๐ Extended low-dose apixaban (2.5 mg BID) reduced recurrent VTE from 10.0% โก๏ธ 1.3% with minimal major bleeding. ๐ฏ Editorial in NEJM urges a shift from binary labels (โprovoked vs unprovokedโ) to a patient-centered, risk-adapted approach. ๐ง Art meets evidence in the decision to extend anticoagulation. ๐ฌ Letโs rethink how we label, risk-stratify, and treat. ๐ #VTE #Apixaban #Anticoagulation #NEJM #HI_PRO #Thrombosis #PrecisionMedicine...
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Dr RR Baliga's Philosophical Discourses: Zhu Xi (China, 1130โ1200 CE) โ Neo-Confucian Philosopher
Dr. Baliga's 'Podkasts for Curious Docs'
๐ Zhu Xi (1130โ1200), a master of Neo-Confucianism, reshaped Chinese philosophy with his focus on rationality, self-cultivation & education. His commentaries on the Four Books guided civil service exams for centuries across East Asia. ๐โจ #Leadership #Philosophy #History #Confucianism
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Gait Speed. Grip Strength. Greater Life. ๐ฆต๐ค๐ A Paradigm Shift in Cardiovascular Recovery for Seniors
Dr. Baliga's 'Podkasts for Curious Docs'
Just read the latest from NEJM? The PIpELINe Trial ๐ฎ๐น changes how we approach cardiac rehab in older adults post-MI! ๐งโค๏ธ ๐ฏ A 12-month, multidomain intervention โ risk factor control, nutrition ๐ฅ, and Otago-based exercise ๐ โ cut CV death/hospitalization from 20.6% โ 12.6% (P=0.01)! ๐ Hospitalizations for heart failure dropped 7.1% โ 1.5%. No serious adverse events. And yes โ better gait speed, handgrip strength, and quality of life too. This is how we shift from survival โก๏ธ functional independence in aging populations. ๐ ๐ Would you apply this model...
info_outline๐ฌ Anemia & Folate: Key Insights
๐ฉธ Anemia is primarily caused by iron deficiency in the U.S., especially in pregnancy (30% prevalence).
๐ NHANES data shows high iron deficiency in young females (up to 77.5% at ferritin <50 ฮผg/L).
โ ๏ธ Causes include heavy menstrual loss, increased pregnancy needs, and low dietary heme iron.
๐ Iron supplements (18 mg/day) help, but >45 mg/day may cause nausea & constipation.
๐ถ Maternal iron status affects infant birth weight, and delayed cord clamping improves newborn iron stores.
๐ In low-income countries, anemia is also linked to malaria, parasites, and hemoglobinopathies.
๐ Folic acid fortification since 1998 has reduced neural-tube defects, making folate deficiency rare in the U.S.