Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Mencius (c. 371โ289 BC) was a prominent Confucian philosopher known as the โSecond Sageโ after Confucius. He emphasized the innate goodness of human nature, advocating for humane governance, moral cultivation, and the welfare of citizens. His teachings greatly influenced Confucianism and later Neo-Confucian thought.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
๐งฌ Clonal haematopoiesis (CH)โespecially with DNMT3A-R882 mutationsโincreases with age and raises leukemia risk. ๐ New studies reveal that metformin targets mutant blood stem cells by suppressing mitochondrial metabolism, sparing healthy cells. ๐ UK Biobank data shows lower CH prevalence in metformin users. ๐ Targeting oxidative phosphorylation may offer a safe, preventative strategy against CH progression.
info_outlineDr. Baliga's 'Got Knowledge Doc?' PODKASTS
In this large real-world study ๐งช using electronic health records ๐, GLP-1RAs and SGLT2isโtwo diabetes drugs ๐โwere associated with a lower risk of Alzheimerโs and related dementias ๐ง in people with type 2 diabetes ๐ฌ. Both showed protective effects ๐ก๏ธ, with no significant difference between them, suggesting promise for drug repurposing โป๏ธ in brain health strategies.
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๐ง Regular endurance exercise boosts brain health by increasing blood flow ๐, enhancing neuroplasticity ๐, and reducing inflammation ๐ฅ. ๐โโ๏ธ High cardiorespiratory fitness (CRF) lowers dementia risk ๐งฉ, supports memory ๐, and promotes the release of powerful brain molecules like BDNF ๐งฌ and irisin ๐ช. โจ In short: Move more, age slower, think sharper!
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๐๏ธ Cataracts are a common cause of vision loss in older adults, leading to blurry vision, glare, and difficulty with daily tasks. ๐ Surgery is safe, quick, and effective โ restoring clarity, reducing fall risk, and even lowering dementia risk. ๐ฌ Advanced lenses can reduce dependence on glasses, while intraocular antibiotics help prevent rare infections. โ ๏ธ Watch out for meds like tamsulosin that may complicate surgery โ always inform your eye doctor!
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๐ฆ Staphylococcus aureus bacteremia (SAB) is a deadly bloodstream infection with high rates of complications like endocarditis and abscesses. ๐ Early detection, MRSA coverage with vancomycin/daptomycin, and source control (๐ช remove catheters, drain abscesses) are critical. ๐ Use echocardiography and VIRSTA score to guide management. โ Once susceptibilities return, de-escalate and tailor therapyโMSSA loves cefazolin!
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๐ง People often say they want big wins (like lotteries), but in practice, they choose what wins more oftenโeven if it pays less. ๐ฎ In experiments, when outcomes are shown side-by-side, we tend to favor the โfrequent winner.โ ๐ This bias can make us overlook rare, high rewardsโshaping real-world choices in money, health, and risk. ๐ Bottom line: Itโs not just what we choose, but how the choice is shown that changes everything.
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Zhuang Zhou, also known as Zhuangzi, was an influential 4th-century BCE Chinese philosopher during the Warring States period. As a foundational figure of Taoism, he authored the Zhuangzi, a text known for its profound philosophical insights, parables, and critiques of societal norms, emphasizing personal freedom and harmony with the Tao. His ideas remain central to Chinese philosophy and continue to inspire discussions on ethics, metaphysics, and human nature.
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๐งด Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. ๐ Greater reduction in HECSI, ๐ better quality of life, and โ ๏ธ fewer side effects make it a promising non-steroidal alternative. ๐ Time to rethink systemic pills โ topical wins hands down! ๐๏ธโ
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๐งฌ Human pelvic evolution reflects a tug-of-war between ๐ถโโ๏ธ efficient walking, ๐ง growing brains, and ๐ผ safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressuresโnot just bipedalism or birth. Larger canals ease delivery but risk ๐ฅ pelvic floor disorders, while narrower ones boost mobility but raise โ ๏ธ labor complications. This study reframes the โobstetrical dilemmaโ as a ๐ multifactorial evolutionary compromise.
info_outline๐ง Migraine is a complex neurological disorder affecting 1 billion people worldwide.
Historically misunderstood, it was once seen as a vascular or psychological issue but is now recognized as a brain network dysfunction involving the hypothalamus and limbic system.
๐ Gepants and CGRP blockers have revolutionized treatment, though they only work for some patients.
Triggers like stress, hormones, diet, and environmental factors play a role, and genetics influences susceptibility.
๐ค AI-driven research is helping predict attacks and personalize treatments, while new studies are shifting focus beyond headaches to cognitive and systemic symptoms.
Future research aims to uncover additional pathways and improve long-term management. ๐