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Dr. RR Baliga’s Philosophical Discourses: Zhuangzi (China, c. 369–286 BCE) – Taoist Philosopher show art Dr. RR Baliga’s Philosophical Discourses: Zhuangzi (China, c. 369–286 BCE) – Taoist Philosopher

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Zhuang Zhou, also known as Zhuangzi, was an influential 4th-century BCE Chinese philosopher during the Warring States period. As a foundational figure of Taoism, he authored the Zhuangzi, a text known for its profound philosophical insights, parables, and critiques of societal norms, emphasizing personal freedom and harmony with the Tao. His ideas remain central to Chinese philosophy and continue to inspire discussions on ethics, metaphysics, and human nature.

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Hands Down, Cream Wins! 🖐️🧴💥 Delgocitinib vs Alitretinoin in Chronic Eczema show art Hands Down, Cream Wins! 🖐️🧴💥 Delgocitinib vs Alitretinoin in Chronic Eczema

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧴 Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. 📉 Greater reduction in HECSI, 😊 better quality of life, and ⚠️ fewer side effects make it a promising non-steroidal alternative. 💊 Time to rethink systemic pills — topical wins hands down! 🖐️✅

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🧠🦴🚼 “Brains, Balance, and Birth: Cracking the Pelvic Code show art 🧠🦴🚼 “Brains, Balance, and Birth: Cracking the Pelvic Code

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧬 Human pelvic evolution reflects a tug-of-war between 🚶‍♀️ efficient walking, 🧠 growing brains, and 🚼 safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressures—not just bipedalism or birth. Larger canals ease delivery but risk 💥 pelvic floor disorders, while narrower ones boost mobility but raise ⚠️ labor complications. This study reframes the “obstetrical dilemma” as a 🔄 multifactorial evolutionary compromise.

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🫁💥 “Lung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸 show art 🫁💥 “Lung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🩸 Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin β2⁺ extracellular vesicles (sEVs) 🧬 that bind platelet GPIb 🧲, triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection 🎯, offering safer, targeted therapeutic opportunities 💉.

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Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog? show art Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog?

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Cancer cachexia isn’t just weight loss—it’s a hijacking of motivation 😔. Elevated IL-6 🔥 activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine 💊 in the nucleus accumbens, leading to effort-based apathy 💤. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway 💡.

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“🧠 Fewer Strokes, 🚫 No Bleeds, ✅ Stronger Choice: Clopidogrel After PCI? show art “🧠 Fewer Strokes, 🚫 No Bleeds, ✅ Stronger Choice: Clopidogrel After PCI?

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧪 SMART-CHOICE 3 in a Nutshell 🟣 Clopidogrel beat 🟠 aspirin post-PCI: 📉 Fewer MACCE (4.4% vs 6.6%) 🩸 Same bleeding risk 🍽️ Fewer GI events   ⚠️ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. 🎯 Verdict: Promising—but not bulletproof.

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Mitochondria. Medicine. Miracles show art Mitochondria. Medicine. Miracles

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🔋 Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving 🫀 baby hearts to protecting 🧠 stroke-affected brains, this tiny powerhouse may revolutionize medicine—one cell at a time. 🧬💉✨

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 Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy show art Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle.   He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.

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Mitochondria the Tiny Travelers, Big Impact, Bold Future show art Mitochondria the Tiny Travelers, Big Impact, Bold Future

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧬 Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells 🚀—healing neurons 🧠, boosting immunity 🛡️, and even aiding cancer cells ⚠️. Scientists are now exploring how to harness this dynamic dance for future therapies 💉.

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From Cold to Bold: The Legacy of Winter Conception show art From Cold to Bold: The Legacy of Winter Conception

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

  ❄️ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. 🔬 Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 🧬 The key factor: Temperature and its diurnal variation before conception — not birth season — predicts adult brown adipose tissue (BAT) function. 📉 Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure...

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More Episodes

🧠 Brain Aging & Research Advances

 

🔍 Key Findings:

Brain Age Gap (BAG): Difference between estimated and chronological brain age.

64 genes identified as influencing brain aging.

13 proteins in blood linked to accelerated/slowed brain aging.

 

🩺 Potential Interventions:

13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing decline.

Plasma proteomics reveals key biomarkers for early intervention.

 

🌍 Influencing Factors:

Socioeconomic status, pollution, and gender inequality impact brain aging.

Functional connectivity decline linked to cognitive disorders.

 

🚀 Future Directions:

Clinical trials needed for drug validation.

Genetic & proteomic studies should expand to diverse populations.