🧬 Targeting Aldosterone: A New Shot at Hypertension 🎯💥
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New breakthrough in hypertension care! 💊 The Launch-HTN trial shows lorundrostat — a selective aldosterone synthase inhibitor — significantly lowers systolic BP in patients with uncontrolled or treatment-resistant hypertension. 📉 −16.9 mmHg vs −7.9 mmHg with placebo (P < .001) 🧪 Safe, well-tolerated, and effective across subgroups. A potential game-changer in aldosterone-targeted therapy! 🔄💥 #Hypertension #Cardiology #ClinicalTrials #PrecisionMedicine
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Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Our latest podcast episode unpacks the 2025 JAMA Review on Type 2 Diabetes 🔬💊 We explore: ✅ New diagnostic strategies ✅ Why GLP-1s & SGLT2is are game-changers ✅ How lifestyle change can lead to remission ✅ Individualizing A1C goals in real-world care 🎙️ Episode Title: “Diagnose, Personalize, Optimize: The 2025 Diabetes Blueprint” 📈 Essential listening for clinicians, educators, and innovators in endocrine & cardiometabolic care. 👉 Tune in now and share with your network! #Type2Diabetes #CardiometabolicCare #GLP1 #SGLT2...
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Early to Bed, Stronger Steps Ahead 💤💪👣”
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
How we sleep tonight shapes how we move tomorrow! 📉🏃♂️ In a large-scale wearable study (📱WHOOP & Fitbit data from >25,000 adults), researchers found: ✅ Sleeping earlier than usual boosts next-day physical activity ❌ Longer or later sleep = less movement 🔥 Max gains came from consistent sleep duration + early bedtime Let’s rethink our 💤 to power our 💥! 📣 Public health campaigns should promote sleep and exercise together—not in competition. 📄 PNAS, June 2025 | doi: #SleepHealth #PhysicalActivity #WearableTech #Chronobiology...
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Wrinkle, Rust, and Rewind: 17 Theories of Why We Age
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🧬 Curious why we age? 🕰️ From DNA damage to developmental programs gone rogue, this new podcast episode dives deep into 17 theories of ageing — some classic, some controversial. 🔍 We explore wear-and-tear, free radicals, telomeres, mitochondria, stem cell exhaustion, and the rising stars of epigenetic drift and hyperfunction theory. 🎙️ Whether you’re a scientist, clinician, or just fascinated by the biology of time, tune in to uncover what really drives the ageing process—and what might one day slow it down. 🧠 Listen now: “Wrinkle, Rust, and...
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💥 Beyond the Block: Cracking the Code of Chest Pain 🔬❤️
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Refractory Angina: Time to Rethink the Diagnosis 🫀💥 Chest pain that defies stents and statins? It may not be your typical obstructive CAD. This podcast unpacks the redefinition of refractory angina — spotlighting INOCA, CMD, vasospasm, and myocardial bridging 🔬⚙️ We explore PET, CMR, CFVR, and wire-based diagnostics 🔎 — and why a multidisciplinary Angina Heart Team is key to transforming care 👩⚕️👨⚕️🧠 🎧 Listen in as we chart a course from frustration to precision — because even stubborn angina has a story and a solution. ...
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Inflammaging: Myth, Marker, or Mismatch? 🧪❓🌐
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🔬🌍 New insights from Nature Aging: Inflammaging isn’t universal! A fascinating cross-cultural study comparing Italy 🇮🇹, Singapore 🇸🇬, Bolivia 🇧🇴, and Malaysia 🇲🇾 shows that age-related inflammation—long considered a hallmark of aging—may actually be a product of industrialized environments. Populations like the Tsimane (Bolivia) and Orang Asli (Malaysian), despite high infection loads, show minimal correlation between cytokines and age-related disease. 📉 Conclusion: Inflammaging is not destiny—it’s context. 🧪 Read the...
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🧠❤️ Predict. Prevent. Protect: AI’s Lifesaving Role in HCM
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 AI vs Sudden Cardiac Death in HCM 🫀🤖 Exciting new study published in Nature Cardiovascular Research showcases MAARS, a multimodal AI model that dramatically improves risk prediction for sudden arrhythmic death in hypertrophic cardiomyopathy patients. 📊 MAARS outperformed current guidelines with AUROC of 0.89 (internal) and 0.81 (external) 🧠 Integrated data: LGE-CMR 🧲, EHR 📋, and echo/CMR reports 💻 ⚖️ Demonstrated fairness across age and sex subgroups 🔍 Transparent predictions via Shapley values and attention heatmaps A leap toward...
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💡 Personalized, Precise, Powerful: The Rise of Cancer Vaccines 🧪
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
“Vax to the Future: Cancer Immunity Revolution 🧬💉” Cancer vaccines are no longer a promise — they’re a precision revolution. From HBV and HPV to cutting-edge mRNA-based neoantigen vaccines, we explore how tumor sequencing + AI + immune checkpoint inhibitors are reshaping oncology. 📈 Real data from trials in melanoma, ccRCC, and pancreatic cancer ⚔️ PD-1 inhibitors meet targeted T cells 🌍 A safer, scalable future for cancer care 🎧 Tune in to Got Knowledge Doc as we decode this game-changing viewpoint from JCI — “Vaccines in Cancer Treatment...
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🍬 Endothelium Under Attack: The Sweetener-Inflammation Link
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
🚨 New Findings on Aspartame & Heart Health! 🍬🫀 A groundbreaking study in Cell Metabolism reveals how aspartame, a common artificial sweetener, may worsen atherosclerosis via an insulin-triggered inflammatory pathway involving the CX3CL1-CX3CR1 axis. 🧪 Key insights from mice and monkeys: – Aspartame spikes insulin via vagus nerve stimulation – Elevated insulin boosts CX3CL1 expression in endothelial cells – CX3CL1 recruits inflammatory monocytes ➡️ plaque growth & instability 🧬 Blocking CX3CR1 in monocytes stopped plaque progression entirely....
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Dr RR Baliga's Philosophical Discourses: Saint Augustine of Hippo (354–430 CE)
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Saint Augustine of Hippo (354–430 CE), a prominent theologian, philosopher, and bishop in Roman North Africa, profoundly influenced Western Christianity and philosophy. Known for works like Confessions, The City of God, and On Christian Doctrine, he developed doctrines on original sin, grace, just war, and ecclesiology. His thoughts shaped medieval theology, inspired Protestant Reformers, and continue to impact Christian teachings.
info_outline🧬 Your mother’s X chromosome may shape how your brain ages.
In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory 🧠🕳️ than those with random X-inactivation. This is due to imprinted genes — some only expressed from the paternal X (Xp) — which are silent when Xm dominates.
🧠💡 Using CRISPR–Cas9, researchers reactivated 3 Xm-silent genes (Sash3, Tlr7, Cysltr1) and saw improved memory and mitochondrial function ⚡🔋.
👩🔬 This highlights inter-female variation in aging and memory — and suggests that epigenetic inheritance from mothers may shape how well we remember… or forget. 🧓🧠❓