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๐ง Big win for brains & blood pressure! In a massive rural China trial (n=33,995), lowering BP with non-physician care โ dementia risk by 15%! A scalable, lifesaving model for LMICs. ๐พ๐๐ #Dementia #Hypertension #GlobalHealth
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๐๐ฌ๏ธ Nasal vaccines: A breath of fresh air in respiratory infection prevention! ๐ Boosts mucosal immunity (SIgA & IgG) ๐ช, reduces transmission ๐ก๏ธ, and protects against COVID-19, influenza, RSV, and more! #Vaccines #PublicHealth #Innovation ๐ฆ ๐
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๐จ New hope for high Lp(a)! ๐ Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. ๐ฌ RNA precision meets cardiac prevention. ๐ Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinA
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๐ฌ๏ธ๐ถโโ๏ธ COPD comes in many forms! From chronic bronchitis ๐ชซ to emphysema ๐จ, frequent exacerbators ๐จ, asthma-COPD overlap ๐ช๏ธ, and eosinophilic type ๐งซ. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCare
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๐ TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! ๐ โ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib ๐ช Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD
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A gut fungus ๐ (Fusarium foetens) secretes FF-C1 ๐งช, a metabolite that inhibits CerS6 and lowers ceramides ๐ฉธโshielding mice from MASH ๐ก๏ธ. Fungi arenโt just freeloadersโthey may be our next therapeutic allies! ๐๐ง #Microbiome #LiverHealth #FungalTherapy #Science
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๐ Obicetrapib: A Breakthrough in LDL Lowering! ๐ Reduced LDL by 29.9% in high-risk patients (p<0.001) ๐ก Promising adjunct to lipid-lowering therapy! #Cardiology #LipidManagement #HeartHealth ๐
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Hereโs a tweet with emojis based on the article: ๐งฌ Middle-age spread decoded! ๐ฐ๏ธ Visceral fat grows in midlife not from bigger cellsโbut new ones! ๐ฏ CP-A cells fire up fat formation via LIFRโSTAT3 ๐ฅ ๐ Targeting them may halt metabolic disease before it starts. #Aging #Obesity #CellBiology #Metabolism ๐งซ Would you like a version with a more humorous tone or one tailored for clinicians?
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๐จ New era in heart disease prediction! ๐งฌ + ๐งช + ๐ค = Meta-prediction model that beats PCE & QRISK3 ๐ Detects hidden CAD risk in young, women & โlow-riskโ groups ๐ฏ Precision prevention just got personal. ๐ซ Published in Nature Medicine #CardioTwitter #AI #Genomics #CAD
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Epicurus (341โ270 BC) was an ancient Greek philosopher who founded Epicureanism, emphasizing the pursuit of a tranquil, happy life through ataraxia (freedom from fear) and aponia (absence of pain). His teachings combined atomism, ethics, and naturalistic theology, advocating simple living, friendship, and the rejection of superstition.
info_outline๐งฌ Your motherโs X chromosome may shape how your brain ages.
In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory ๐ง ๐ณ๏ธ than those with random X-inactivation. This is due to imprinted genes โ some only expressed from the paternal X (Xp) โ which are silent when Xm dominates.
๐ง ๐ก Using CRISPRโCas9, researchers reactivated 3 Xm-silent genes (Sash3, Tlr7, Cysltr1) and saw improved memory and mitochondrial function โก๐.
๐ฉโ๐ฌ This highlights inter-female variation in aging and memory โ and suggests that epigenetic inheritance from mothers may shape how well we rememberโฆ or forget. ๐ง๐ง โ