π‘οΈ Warriors, Watchers & Worn-Outs: Mapping Immune Identity
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠New study reveals 4 stable #Immunotypes in healthy adults! Each with unique π₯inflammatory, π¦ CMV-driven, π§quiet, or π₯aging-linked immune traits. They predict LPS response better than age or sex. Welcome to the era of immune fingerprinting! π§ͺπ§ #PrecisionMedicine #Immunology #Multiomics
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Glycemic Wisdom: π Spikes, Stats & Surprises
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π₯ Not all carbs are created equal β or digested the same! A new study shows glycemic responses vary wildly by individual ππ₯ππ Your microbiome, metabolism, and ethnicity all matter! Precision nutrition is the future π¬π§¬π #GlycemicResponse #CGM #NutritionScience #T2D π½οΈ
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π§ πͺ𧬠Aging Redefined: Cracking the Epigenome with the "Intrinsic Capacity" Clock
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠A new epigenetic clock predicts your functional age β not just birthdays! π°οΈ Built from 91 CpGs, the IC Clock outperforms GrimAge & others at predicting mortality πͺ Linked to T-cell health, π« lung function & π omega-3 intake π Nature Aging: https://doi.org/10.1038/s43587-025-00883-5 #Aging #Epigenetics #Longevity #Immunosenescence Doximity
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π― Nuts About Health: Daily Dose, Daily Gains?
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π₯ Daily almonds = big wins for metabolic health! β β LDL & total cholesterol β β Vitamin E (Ξ±-tocopherol) β β Gut inflammation (calprotectin, MPO) β No change in systemic inflammation or weight Crunch wisely, live heart-smart! β€οΈπ§ #Nutrition #MetabolicSyndrome #RCT #Almonds #GutHealth
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𧬠Age, Clocks, and Plasma: The Biology of Rejuvenation
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π§ͺ Can we turn back the clock? A new RCT shows TPE + IVIG reversed biological age by 2.6 years in older adults! π𧬠β Boosted naΓ―ve T cells β οΈ Small sample, no clinical endpoints π Personalized markers predict response #Aging #LongevityScience #Epigenetics π§πβ¨
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π Eat the Polyphenol Rainbow: Quantity + Variety = Longevity
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π₯ New study in Nature Food: Greater diversity of flavonoid intakeβnot just quantityβlinked to β risk of death, diabetes, heart disease & more πππ΅ Eat the rainbow daily: apples, tea, berries, citrus, greens = longevity boost πͺ𧬠#Nutrition #Longevity #Flavonoids
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Dr RR Baliga's Philosophical Discourses: Marcus Aurelius (Rome, 121β180 CE) β Roman Emperor and Stoic Philosopher
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Marcus Aurelius (121β180 CE), a Roman emperor and prominent Stoic philosopher, ruled from 161 to 180 CE. As the last of the Five Good Emperors, his reign marked the end of the Pax Romana, a period of relative peace in the Roman Empire. Known for his military campaigns against Parthians and Germanic tribes, he also endured the devastating Antonine Plague. His philosophical reflections, compiled in Meditations, offer insight into Stoic ethics and personal leadership. Marcus was succeeded by his son Commodus, whose rule marked a decline in Romeβs stability. His legacy endures in both...
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π©Έ Tiny Messengers, Big Damage: How RBC EVs Wreck Vascular Health in Diabetes
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
π©Έ New JCI study reveals how RBC-derived EVs 𧬠in #Type2Diabetes sneak into endothelial cells π§«, delivering arginase-1 & sparking oxidative stress π₯βa hidden cause of vascular dysfunction. Blocking EV uptake = π‘ new therapy? π https://doi.org/10.1172/JCI180900 #CardioTwitter #Diabetes #VascularBiology
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π§ From Prevention to Precision of Alzheimers Disease: New Frontiers
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
Big shift in Alzheimerβs care! We can now predict it years in advance using π©Έ biomarkers like p-tau217, 𧬠genetic risk, & π€ AI-analyzed retina scans. Prevention = lifestyle π₯¦πββοΈπ€, vaccines π, & maybe GLP-1s π. Why wait to treat when you can PREVENT? π #Alzheimers #PrecisionMedicine #AI
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π©Έ Fueling Inflammation: Haematometabolism & Heart Disease
Dr. Baliga's 'Got Knowledge Doc?' PODKASTS
𧬠Did you know your blood cell metabolism could fuel heart disease? π Disrupted haematometabolism = more inflammation, less cleanup π§Ή Efferocytosis fails β plaques grow π§ Aging + CHIP mutations = π₯ risk π₯ Fix it with fasting, fitness & future therapies! #CardioTwitter #MedEd #Haematometabolism β€οΈ
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βοΈ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults.
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π¬ Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat.
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𧬠The key factor: Temperature and its diurnal variation before conception β not birth season β predicts adult brown adipose tissue (BAT) function.
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π Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure (TEE) β even years later.
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π§ Researchers propose PfOHaD (Pre-fertilization Origins of Health and Disease) β expanding DOHaD to include paternal cold exposure as a metabolic epigenetic switch.