Dr RR Baliga's Philosophical Discourses: Zeno of Citium (Greece, c. 334โ262 BCE) โ Founder of Stoicism
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Zeno of Citium (c. 334 โ c. 262 BC) was a Hellenistic philosopher from Cyprus and the founder of Stoicism. His philosophy emphasized living in harmony with nature and practicing virtue to attain peace of mind (ataraxia). Zenoโs teachings influenced ethics, logic, and natural philosophy, laying the foundation for Stoicismโs prominence during the Roman era and beyond. Despite losing his original writings, Zenoโs ideas survived through the works of later Stoics like Cleanthes and Chrysippus.
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๐ซ Flow vs Form ๐ ๏ธ: Guiding PCI with FFR or IVUS in the FLAVOUR II Trial ๐ฏ
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๐จ New from #FLAVOURII: Angio-FFR vs IVUS to guide PCI ๐ซ ๐ฏ Similar outcomes ๐ Fewer stents ๐ง Smarter decisions Is flow-based guidance the future? ๐ #CardioTwitter #FFR #IVUS #Intervention ๐ฐ Lancet 2025 | ๐ RCT | ๐จ๐ณ 1839 patients
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๐ Next-Gen Weight Loss: Tirzepatideโs Winning Edge Over Semaglutide
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๐ Tirzepatide Triumphs! ๐ช In a head-to-head trial, #Tirzepatide led to greater weight loss (-20.2%) compared to #Semaglutide (-13.7%) over 72 weeks! ๐๐ Superior waist reduction too! #ObesityManagement #WeightLoss #GLP1 #GIP ๐ฉบ๐ #CardiometabolicHealth #ClinicalResearch
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Head Hits, Heart Risks: Concussions in Football Spike Cardiovascular Danger ๐โค๏ธ
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๐๐ฅ Concussions in football donโt just hit the brainโthey impact the heart too! ๐๐ซ New study shows increased BP, arterial stiffness, and cardiac risks in NCAA athletes post-concussion. ๐ง โก๏ธโค๏ธ #Cardiology #SportsMedicine #ConcussionRisk #HeartHealth
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๐ฆ Microbes, Mutations, and Malignancy: Unveiling the GutโBlood Cancer Axis ๐
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๐งฌ A molecule from aging gut bacteriaโADP-heptoseโenters the bloodstream, activates ALPK1, and triggers NF-ฮบB signaling, driving the expansion of mutant blood stem cells. ๐ฆ ๐ง This discovery links gut health to leukemia risk and reveals new targets like ALPK1 and UBE2N for cancer prevention. ๐ฅ๐ฉธ
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Lower Blood Pressure, Sharper Minds, Less Dementia, Longer Lives ๐ง ๐๐พ
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๐ง Big win for brains & blood pressure! In a massive rural China trial (n=33,995), lowering BP with non-physician care โ dementia risk by 15%! A scalable, lifesaving model for LMICs. ๐พ๐๐ #Dementia #Hypertension #GlobalHealth
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๐ฌ๏ธ Breathe Easy: Nasal Vaccines to the Rescue!
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๐๐ฌ๏ธ Nasal vaccines: A breath of fresh air in respiratory infection prevention! ๐ Boosts mucosal immunity (SIgA & IgG) ๐ช, reduces transmission ๐ก๏ธ, and protects against COVID-19, influenza, RSV, and more! #Vaccines #PublicHealth #Innovation ๐ฆ ๐
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๐งฌ Silencing Risk: Lepodisiran vs Lp(a)
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๐จ New hope for high Lp(a)! ๐ Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. ๐ฌ RNA precision meets cardiac prevention. ๐ Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinA
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๐จ Breathing Battles: Navigating COPD Phenotypes
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๐ฌ๏ธ๐ถโโ๏ธ COPD comes in many forms! From chronic bronchitis ๐ชซ to emphysema ๐จ, frequent exacerbators ๐จ, asthma-COPD overlap ๐ช๏ธ, and eosinophilic type ๐งซ. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCare
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๐ TANDEM Triumph: Dual Power for LDL Cholesterol Reduction!
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๐ TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! ๐ โ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib ๐ช Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD
info_outlineCancer cachexia isnโt just weight lossโitโs a hijacking of motivation ๐. Elevated IL-6 ๐ฅ activates a brainstem-to-basal ganglia circuit ๐ง that suppresses dopamine ๐ in the nucleus accumbens, leading to effort-based apathy ๐ค.
Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway ๐ก.