π« Flow vs Form π οΈ: Guiding PCI with FFR or IVUS in the FLAVOUR II Trial π―
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π¨ New from #FLAVOURII: Angio-FFR vs IVUS to guide PCI π« π― Similar outcomes π Fewer stents π§ Smarter decisions Is flow-based guidance the future? π #CardioTwitter #FFR #IVUS #Intervention π° Lancet 2025 | π RCT | π¨π³ 1839 patients
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π Next-Gen Weight Loss: Tirzepatideβs Winning Edge Over Semaglutide
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π Tirzepatide Triumphs! πͺ In a head-to-head trial, #Tirzepatide led to greater weight loss (-20.2%) compared to #Semaglutide (-13.7%) over 72 weeks! ππ Superior waist reduction too! #ObesityManagement #WeightLoss #GLP1 #GIP π©Ίπ #CardiometabolicHealth #ClinicalResearch
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Head Hits, Heart Risks: Concussions in Football Spike Cardiovascular Danger πβ€οΈ
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ππ₯ Concussions in football donβt just hit the brainβthey impact the heart too! ππ« New study shows increased BP, arterial stiffness, and cardiac risks in NCAA athletes post-concussion. π§ β‘οΈβ€οΈ #Cardiology #SportsMedicine #ConcussionRisk #HeartHealth
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π¦ Microbes, Mutations, and Malignancy: Unveiling the GutβBlood Cancer Axis π
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𧬠A molecule from aging gut bacteriaβADP-heptoseβenters the bloodstream, activates ALPK1, and triggers NF-ΞΊB signaling, driving the expansion of mutant blood stem cells. π¦ π§ This discovery links gut health to leukemia risk and reveals new targets like ALPK1 and UBE2N for cancer prevention. π₯π©Έ
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Lower Blood Pressure, Sharper Minds, Less Dementia, Longer Lives π§ ππΎ
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π§ Big win for brains & blood pressure! In a massive rural China trial (n=33,995), lowering BP with non-physician care β dementia risk by 15%! A scalable, lifesaving model for LMICs. πΎππ #Dementia #Hypertension #GlobalHealth
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π¬οΈ Breathe Easy: Nasal Vaccines to the Rescue!
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ππ¬οΈ Nasal vaccines: A breath of fresh air in respiratory infection prevention! π Boosts mucosal immunity (SIgA & IgG) πͺ, reduces transmission π‘οΈ, and protects against COVID-19, influenza, RSV, and more! #Vaccines #PublicHealth #Innovation π¦ π
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𧬠Silencing Risk: Lepodisiran vs Lp(a)
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π¨ New hope for high Lp(a)! π Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. π¬ RNA precision meets cardiac prevention. π Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinA
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π¨ Breathing Battles: Navigating COPD Phenotypes
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π¬οΈπΆββοΈ COPD comes in many forms! From chronic bronchitis πͺ« to emphysema π¨, frequent exacerbators π¨, asthma-COPD overlap πͺοΈ, and eosinophilic type π§«. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCare
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π TANDEM Triumph: Dual Power for LDL Cholesterol Reduction!
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π TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! π β -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib πͺ Safe, effective, and oral! #Cardiology #LipidManagement #ASCVD
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Fungal Pharmacists, Fatty Liver, Future Frontiers π§¬π©Έπ
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A gut fungus π (Fusarium foetens) secretes FF-C1 π§ͺ, a metabolite that inhibits CerS6 and lowers ceramides π©Έβshielding mice from MASH π‘οΈ. Fungi arenβt just freeloadersβthey may be our next therapeutic allies! ππ§ #Microbiome #LiverHealth #FungalTherapy #Science
info_outlineπ¨ New from #FLAVOURII: Angio-FFR vs IVUS to guide PCI π«
π― Similar outcomes
π Fewer stents
π§ Smarter decisions
Is flow-based guidance the future? π
#CardioTwitter #FFR #IVUS #Intervention
π° Lancet 2025 | π RCT | π¨π³ 1839 patients