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📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction show art 📊 Polygenic Risk Scores, 💉 Biomarkers, ❤️ Prevention: A New Era in CAD Prediction

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Insights on Heart Attack Risk! 🧬❤️   A must-read from Circulation: Genomic and Precision Medicine—Bhattacharya et al. show that Polygenic Risk Score (PRS) rivals traditional giants like hypertension in predicting MI! 💥   📊 With an R² loss of 12.4% and PAR of 38.4%, PRS isn’t just academic—it’s actionable. Add in hsCRP and Lp(a), and we’re entering a new era of CAD risk stratification.   🔍 From base to full model: ➡️ R²: 0.021 → 0.053 ➡️ C-statistic: 0.65 → 0.73 ➡️ PAR: 84.3%   Let’s embrace the fusion of clinical +...

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💪🍊 “Flavonoid Fightback: Apigenin Saves Muscle, Not Waistlines” show art 💪🍊 “Flavonoid Fightback: Apigenin Saves Muscle, Not Waistlines”

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Research Alert! 💡 Just explored a fascinating preclinical study on apigenin 🧪—a flavonoid found in parsley & chamomile 🌿—that prevents muscle loss in aging, obese rats 🐀💪.   📉 While it didn’t stop weight gain or fat buildup, apigenin boosted muscle mass, reduced fibrosis 🦵, and activated anabolic signaling (p70S6K) 🔁.   💊 Could this be a future nutraceutical for sarcopenic obesity and healthy aging? More clinical research needed—but the signal is strong. 🚦   #Apigenin #Flavonoids #Sarcopenia #Obesity #MuscleHealth #Aging...

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“Shock, Sync, Save 🫀: 2025 AUC Updates Explained” show art “Shock, Sync, Save 🫀: 2025 AUC Updates Explained”

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New in 2025! The ACC/AHA Appropriate Use Criteria for ICDs, CRT, and Pacing just got a major upgrade! 🫀📊 Covering 335 real-world scenarios, this document is your go-to guide for when (and when not) to implant. 💡   What’s 🔥 in the update? ⚡ Leadless & conduction system pacing 🔁 CRT refined for better outcomes 🧠 Smart use in LVADs, post-transplant, & more   👩‍⚕️ Clinicians: Make device decisions with clarity, confidence, and evidence. 📥 Download our podcast + slides to stay ahead.   #Cardiology #ICD #CRT #Pacing #AUC #HeartFailure #EP...

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Dr. RR Baliga’s Philosophical Discourses: : Adi Shankaracharya (India, 788–820 CE) - – Advaita Vedanta Philosopher show art Dr. RR Baliga’s Philosophical Discourses: : Adi Shankaracharya (India, 788–820 CE) - – Advaita Vedanta Philosopher

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧘‍♂️📿 Discover the timeless wisdom of Adi Shankaracharya (788–820 CE) — the master of Advaita Vedanta who redefined spirituality with concepts like Atman, Brahman & Sanyasa. His teachings on non-duality still inspire seekers worldwide. 🌍📚 #Philosophy #Vedanta #Spirituality

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Coronary Plaque Rupture. Erosion. Revelation. 🔬🫀🧠 show art Coronary Plaque Rupture. Erosion. Revelation. 🔬🫀🧠

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🫀 New insights from Covani et al. and Ben-Yehuda’s editorial reveal a striking paradox: more cardiovascular risk factors 🔥 = more plaque rupture, but less erosion! 🧊   Using OCT imaging, they show how traditional risks drive inflammatory, rupture-prone plaques, while erosion may follow a different path altogether—less lipid, less inflammation, more mystery. 🧬   🎯 Takeaway: Precision prevention must evolve. Not all plaques (or patients) follow the same script.   🔗 Dive into this convergence of epidemiology & imaging 👉 #PlaqueVulnerability #STEMI...

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🌫️ The Exposome Effect: What’s in Your Air, Food, and Life? 🍔🧪🚦 Everything but DNA — The New Frontier in Health show art 🌫️ The Exposome Effect: What’s in Your Air, Food, and Life? 🍔🧪🚦 Everything but DNA — The New Frontier in Health

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🌍🔬 What’s shaping your health beyond your genes?   Introducing our latest Got Knowledge Doc podcast episode: “Beyond Genes, Beneath the Skin 🧬🌫️” — a deep dive into the exposome, the totality of your environmental exposures from womb to tomb.   From microplastics to sleep, PFAS to social stress, we’re mapping the missing link in precision medicine. 🎧 Tune in to explore why the future of health might depend less on your DNA and more on your data trail.   🧠 Prevention. 📊 Policy. 💊 Personalization.   #Exposome #PrecisionMedicine...

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💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart show art 💓 TREGs, Fibrosis & Hope: Rewiring the HCM Heart

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Insights in Hypertrophic Cardiomyopathy (HCM)! 💓 Groundbreaking research shows that regulatory T cells (TREGs) can reduce fibrosis, suppress inflammation, and even improve heart function in HCM 🧬🛡️   From adoptive TREG transfer to IL-2 therapy, immunomodulation is emerging as a promising strategy alongside genetic and myosin-targeted treatments 💉📉   🧠 A must-read for cardiologists, immunologists & translational researchers! 📄 Wang et al., Sci. Transl. Med. 2025 🔗 #Cardiology #HCM #TREG #Immunotherapy #Fibrosis #PrecisionMedicine...

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💤🧠 Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease show art 💤🧠 Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🧠💤 Just dropped our latest Got Knowledge Doc podcast: “Flush, Sleep, Forget: The Glymphatic Code in Alzheimer’s Disease” 🧬🎧   We explore how the brain’s nighttime rinse cycle clears toxic proteins like amyloid β and tau—and what happens when that system breaks down. From rodent models to human MRI, it’s a story of sleep, science, and hope. 🌙🔬   Listen in to learn how advancing glymphatic research might open doors to early detection and prevention of Alzheimer’s. 🧪🧩   #AlzheimersDisease #GlymphaticSystem #Neuroscience #SleepScience...

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Gut Talks to the Heart 🥗💓🧠: The Incretin Connection show art Gut Talks to the Heart 🥗💓🧠: The Incretin Connection

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

🚨 New Podcast Episode! 🎙️ “Gut Talks to the Heart 🥗💓🧠: The Incretin Connection”   Did you know that GLP-1 and GIP do far more than control blood sugar? These humble gut hormones orchestrate perfusion, reduce inflammation, protect the brain, heart, kidneys—and may even slow cognitive decline.   💊 From diabetes care to cardio-renal-neuro protection, incretin-based therapies are rewriting the rules of metabolism.   🔗 Tune in to learn how your next meal could be triggering an endocrine symphony.   #Cardiology #Endocrinology #Incretins #GLP1 #GIP...

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👄 Mouths Heal Better: What Your Skin Can Learn from Oral Wounds show art 👄 Mouths Heal Better: What Your Skin Can Learn from Oral Wounds

Dr. Baliga's 'Got Knowledge Doc?' PODKASTS

Exciting new insights from Science Translational Medicine (2025)!   Researchers uncovered how the GAS6–AXL–FAK axis determines whether wounds heal with scars or regeneration. 🧬💉   💡 Activating AXL with GAS6 rewires fibrotic healing into scarless repair — especially in the oral mucosa. 💥 Blocking AXL flips the script, leading to fibrosis even in normally regenerative tissues.   This could revolutionize how we approach scar prevention and tissue regeneration. 🩹✨   #RegenerativeMedicine #WoundHealing #Fibrosis #AXL #FAK #PrecisionMedicine #GAS6 #scRNAseq...

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More Episodes

⚡Gatekeepers of Strength: Allopurinol, Calcium & the RyR Revolution”!

 

Did you know that an old gout drug might hold the key to reversing age-related muscle weakness and heart failure? Using cryo-EM, researchers found that allopurinol and xanthine derivatives directly activate ryanodine receptors—calcium channels essential for muscle contraction.

 

💡 This could change how we think about cardiac therapeutics and sarcopenia. Tune in for the full story—explained for med students, researchers, and curious minds alike.

 

🎧 Listen. Learn. Share. Let’s unlock the power within. 💪🧠 #PrecisionMedicine #Cardiology #MuscleScience #Allopurinol #RyR #MedicalEducation #GotKnowledgeDoc