Why Women’s Brain Health Is at Risk in Midlife (and What You Can Do Now) with Emma Heming-Willis & Helen Christoni
The Resetter Podcast with Dr. Mindy
Release Date: 01/12/2026
The Resetter Podcast with Dr. Mindy
What if menopause isn’t something to fix, but something to understand? In this solo episode, Dr. Mindy Pelz shares Chapter One of her new book Age Like a Girl and breaks down the real purpose of menopause through neuroscience, hormones, and evolution. She explains how the decline of estrogen and progesterone reshapes the female brain, why so many women experience anxiety, mood changes, and brain fog in midlife, and how this transition may actually be designed to reconnect women with their authentic voice, clarity, and power. If this conversation resonates with you, the audiobook of Age Like...
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If you’ve been trying to lose weight and feel stuck, this episode will reframe everything you’ve been taught. In this solo episode, Dr. Mindy Pelz explains why weight loss is not a calorie problem, it’s a hormonal one. She breaks down how insulin and cortisol control fat storage, why vitamin D acts like a hormone in the body, and how one simple morning habit can help reset your circadian rhythm and support stubborn fat loss. Dr. Mindy introduces the idea of a weight loss toolbox, reminding you that no single strategy works for everyone. She also answers listener questions about weight...
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In this powerful episode, I’m joined by Emma Heming-Willis and Helen Christoni for an honest conversation about women’s brain health, dementia risk, emotional overload, and the profound changes women experience in midlife. Women are nearly twice as likely as men to develop Alzheimer’s disease, yet most are never taught how menopause, estrogen decline, chronic stress, caregiving, and emotional suppression impact the female brain. In this episode, we unpack the difference between dementia and Alzheimer’s, why brain changes can begin decades before diagnosis, and why midlife is a critical...
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Hormone Replacement Therapy is back in the spotlight, and many women are asking the same questions: Is it safe? Is it right for me? And why does it still feel so confusing? In this solo episode, Dr. Mindy Pelz breaks down what really happened after the Women’s Health Initiative study, why the black box warning was added and later removed, and what newer research has clarified about HRT, timing, hormone type, and delivery method. She explains why lifestyle and metabolic health are the missing pieces in this conversation and why HRT should never be viewed as a standalone solution. This episode...
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What actually happens inside your body when you don’t eat for 72 hours? Fasting for three days has become one of the most talked-about healing tools — but it’s also one of the most misunderstood. Some people believe it’s dangerous. Others think it’s a quick fix. The truth lives somewhere in between. In this solo episode, I walk you step-by-step through what happens in the body during a 72-hour fast, from blood sugar shifts and ketone production to autophagy, inflammation reduction, immune system renewal, and brain healing. This episode is designed to educate, not pressure. We’ll...
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Big Wellness is booming and middle-aged women are the target. In this solo episode of The Resetter Podcast, I break down why the wellness industry has exploded, why women in midlife are especially vulnerable to being sold quick fixes, and how to stop outsourcing your health to supplements, influencers, and viral advice. After reading a New York Times article titled “Big Wellness Loves Middle-Aged Women,” I wanted to give you a framework for thinking critically about what you’re being sold, whether it’s a supplement, a biohack, or even a medication. This episode is not about telling you...
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Women in midlife are questioning their marriages at record rates often feeling more independent, less willing to people-please, and deeply hungry for real emotional connection. But what is actually happening inside women (and men) during this season of life? In this timely and powerful episode, I sit down with renowned therapist and bestselling author Terry Real to unpack what’s really driving the “gray divorce” trend — and why so many long-term relationships feel strained during perimenopause and postmenopause. And if you’ve ever wondered whether midlife relationship struggles mean...
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Women in midlife are being told everywhere to “lift heavy,” “stop doing cardio,” and “hack your hormones” for better metabolic health. But what is actually TRUE for the menopausal body? In this timely re-release, I’m bringing back one of the most important and misunderstood conversations I’ve ever had — with exercise physiologist and researcher Dr. Stacy Sims. If you’ve been confused about how to work out in your 40s, 50s, 60s and beyond, this episode will give you clarity, confidence, and a science-backed plan to finally feel strong in your body again. Stacy and I walk...
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Join Dr. Mindy for an eye-opening conversation with relationship expert Jillian Turecki on what really happens to long-term relationships during women’s midlife and menopausal transition. They unpack why so many women experience an awakening between ages 40–60, why their needs change, and why this shift often collides with what their long-term partner expects. If you’ve ever wondered why your relationship feels different in midlife, this episode will give you clarity, language, and powerful tools to support your next chapter. To view full show notes, resources mentioned,...
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In this solo episode, Dr. Mindy breaks down the 12 neurochemicals that shift in menopause and why you suddenly feel different. Learn how to bring back your mood, memory, motivation, and sleep with simple lifestyle tools — and why this neurochemical reset is part of your biological design. To view full show notes, more information on our guests, resources mentioned in the episode, discount codes, transcripts, and more, visit Check out our community membership at Please note our medical disclaimer.
info_outlineIn this powerful episode, I’m joined by Emma Heming-Willis and Helen Christoni for an honest conversation about women’s brain health, dementia risk, emotional overload, and the profound changes women experience in midlife.
Women are nearly twice as likely as men to develop Alzheimer’s disease, yet most are never taught how menopause, estrogen decline, chronic stress, caregiving, and emotional suppression impact the female brain. In this episode, we unpack the difference between dementia and Alzheimer’s, why brain changes can begin decades before diagnosis, and why midlife is a critical window for awareness and prevention, not fear.
We also explore how nervous system dysregulation shows up as irritability, withdrawal, resentment, or burnout, why so many women feel disconnected from themselves in their 40s and 50s, and how telling the truth, emotionally and relationally, becomes essential for both brain and body health.
To view full show notes, resources mentioned, discount codes, transcripts, and more, visit
https://drmindypelz.com/ep322/
Check out our community membership at
https://resetacademy.drmindypelz.com
Please note our medical disclaimer.