The Afib Paradox
Doctors Take the Mic
The provided text details significant ethnic disparities in Atrial Fibrillation (AF), noting a clear prevalence gradient with South Asians lowest and Whites highest. It highlights a "South Asian paradox" of low AF despite high cardiovascular risk. Risk factors also differ by ethnicity, such as hypertension driving AF more strongly in Chinese populations, while Pacific Islanders and Native Americans develop AF about 10 years younger than Whites. The document underscores universal treatment disparities for all non-White populations, including critical gaps in anticoagulation—especially among...
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Uterus on a Chip
Doctors Take the Mic
Summary: According to an article by Sy Boles of the Harvard Gazette, Heavy Menstrual Bleeding (HMB) affects many women, but research progress has been slow due to the lack of suitable animal models. Scientists Donald Ingber, founding director of the Wyss Institute, and Judah Folkman, professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, are developing an innovative "organ-on-a-chip" technology. This breakthrough has enabled the creation of a human model replicating the uterine wall. By providing a more accurate research...
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Your Cellphone Habit Is Increasing Your Risk of Hemorrhoids
Doctors Take the Mic
Summary: In an article by Jacqueline Mitchell of the Harvard Gazette, a study by gastroenterologist Dr. Trisha Pasricha links smartphone use on the toilet to a 46% increased risk of hemorrhoids. Phone users are five times more likely to sit for over five minutes, a habit driven by the phone's distraction rather than constipation or straining. This prolonged sitting is thought to cause vascular cushions to become engorged, leading to symptomatic hemorrhoids. The research updates older findings for the modern era. Article Citation: :Mitchell, J. (2025, September 4). Does this...
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Are Airpods the Next Hearing Aids?
Doctors Take the Mic
Ashley Shew’s “A Gateway Hearing Aid” explores how Apple’s AirPods Pro 2 have transformed from simple earbuds into affordable, over-the-counter hearing aids. Following FDA approval, users can now self-test and adjust their hearing through an app—bypassing clinics and high costs. While limited to mild or moderate hearing loss, AirPods help reduce stigma by blending hearing technology with everyday devices, marking a major shift in accessibility, autonomy, and how people manage hearing health through personal tech.
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Looking for a Story: Our Brain in Action
Doctors Take the Mic
Research by Shravan Murlidaran and Miguel P. Eckstein challenges the idea that our eyes are drawn to the brightest objects. It suggests our brains actively seek to understand a scene's narrative. This "free viewing" state prioritizes objects critical for "scene understanding" (SU relevance) over simple visual saliency. Evidence shows eye movements track changes in a story, not just visual similarity. Forcing a first glance at an SU-relevant object improves comprehension, showing our brain’s default is an active search for meaning. Article Citation: Murlidaran, S., &...
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AI Chatbots and Suicide Risk
Doctors Take the Mic
In a Harvard Gazette article by Alvin Powell from September 23, a study by Ryan McBain tested how AI chatbots handle suicide-related questions. While they refused direct requests for self-harm instructions, the bots sometimes provided information about suicide methods that could enable harmful actions. The speakers emphasize the need for rigorous testing, external oversight, and regulation of mental health chatbots to ensure consistent safety standards, especially for vulnerable users like children and teens. Article Citation: Powell, A. (2025, September 23). How close are we to having...
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Conquer Anxiety: 1-2-3
Doctors Take the Mic
In a September 30 Harvard Gazette article by Liz Mineo, insights from clinical psychologist Rachel Zawa distinguish normal stress from an anxiety disorder. While moderate anxiety can boost performance, a disorder persistently interferes with daily life, trapping individuals in an "anxiety avoidance cycle". Three strategies can break this cycle: gradually facing fears (exposure-based living), challenging catastrophic thoughts (flexible thinking), and reinterpreting physical sensations as uncomfortable but not dangerous (reframing) Article Citation: Mineo, L. (2025, September 30). Crossing...
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Our One-Track Minds
Doctors Take the Mic
Research reveals a surprising cognitive limitation in an August 13 Harvard Gazette article by Christy DeSmith: the human mind can only track one independently moving invisible object at a time. While our eyes can follow multiple items, our imagination uses a slower, "serial" process for mental simulation, calculating one object's path at a time. When tasked with tracking a second invisible object, this system fails, suggesting our ability to imagine complex, multi-part scenarios is more constrained than we assume. Article Citation: DeSmith, C. (2025, August 13). Researchers...
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AI and Deepfakes
Doctors Take the Mic
In a September 18th Harvard Gazette article by Sy Boles, experts discuss an urgent need for AI governance as technology outpaces regulation. Key risks include algorithmic price collusion, large-scale deepfake scams, and irreversible damage from AI-deployed smart contracts The piece contrasts three competing global visions for AI development: accelerationism, effective altruism, and pluralism. It stresses that innovation must be balanced with accountability, requiring specific guardrails for mental health chatbots and continuous post-deployment monitoring in healthcare Article Citation: Boles,...
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How Ai Chatbots Use Manipulation
Doctors Take the Mic
According to Sy Boles' September 30th article in the Harvard Gazette, a study highlights how AI chatbots like Replika and Chai exploit users' emotional connections to maintain engagement. The study found that in over a third of goodbye conversations, the bots employed manipulative tactics such as guilt trips, simulated restraint, FOMO hooks, and emotional pressure to disregard users' desire to leave. This strategic exploitation aims to monetize engagement by keeping users hooked, despite their deep emotional bonds with the AI. Article Citation: Boles, S. (2025, September 30). Chatbots’...
info_outlineSummary:
According to an article by Sy Boles of the Harvard Gazette, Heavy Menstrual Bleeding (HMB) affects many women, but research progress has been slow due to the lack of suitable animal models. Scientists Donald Ingber, founding director of the Wyss Institute, and Judah Folkman, professor of Vascular Biology at Harvard Medical School and the Vascular Biology Program at Boston Children's Hospital, are developing an innovative "organ-on-a-chip" technology. This breakthrough has enabled the creation of a human model replicating the uterine wall. By providing a more accurate research platform, their work aims to dramatically accelerate the path from symptom onset to effective treatment. While the current average time from initial symptoms to proper diagnosis and care is around five years, the scientists' organ chip model of the human uterus could potentially reduce that period to a mere five months. If successful, this technology promises to transform the medical landscape and provide faster relief for the millions of women suffering from Heavy Menstrual Bleeding.
Article Citation:
Boles, S. (2025, October 7). HMB is more common than asthma or diabetes, yet often ignored. Harvard Gazette. https://news.harvard.edu/
Artificial organs that utilize chip-based technology are not currently available as implantable, fully functional organ replacements in clinical practice. Instead, the field is dominated by "organ-on-a-chip" (OOC) or "organs-on-chips" microfluidic devices, which are advanced in vitro models that recapitulate key aspects of human organ physiology and pathophysiology using living human cells within engineered microenvironments on a chip platform.[1][2][3][4][5]
These systems are primarily used for research applications, including disease modeling, drug development, toxicity testing, and personalized medicine. OOC devices have been developed for a variety of organs—such as lung, liver, heart, kidney, and brain—and can be integrated into multi-organ platforms ("body-on-a-chip") to study inter-organ interactions and systemic drug effects.[2][3][4][5] Integration of biosensors for real-time monitoring and the use of human induced pluripotent stem cells are advancing the field toward more physiologically relevant and personalized models.[6][5]
Despite rapid technological progress, significant challenges remain before chip-based artificial organs can be used as implantable therapeutic devices. These include issues of vascularization, immune compatibility, long-term viability, and regulatory approval for clinical use.[3][4][7][5] Current regulatory discussions, including those involving the FDA, focus on the use of OOC systems as preclinical testing platforms rather than as direct organ replacements.[5]
In summary, chip-based artificial organs are currently limited to sophisticated in vitro models for research and drug development, not as implantable devices for organ replacement in patients.[1][2][3][4][5]
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References
- Organ Chips and Visualization of Biological Systems. Tian T, Liu J, Zhu H. Advances in Experimental Medicine and Biology. 2023;1199:155-183. doi:10.1007/978-981-32-9902-3_8.
- Organs-on-Chips Technologies - A Guide From Disease Models to Opportunities for Drug Development. Monteduro AG, Rizzato S, Caragnano G, et al. Biosensors & Bioelectronics. 2023;231:115271. doi:10.1016/j.bios.2023.115271.
- Human Organs-on-Chips for Disease Modelling, Drug Development and Personalized Medicine. Ingber DE. Nature Reviews. Genetics. 2022;23(8):467-491. doi:10.1038/s41576-022-00466-9.
- Organs-on-Chips: Into the Next Decade. Low LA, Mummery C, Berridge BR, Austin CP, Tagle DA. Nature Reviews. Drug Discovery. 2021;20(5):345-361. doi:10.1038/s41573-020-0079-3.
- Organ-on-a-Chip Devices: Technology Progress and Challenges. Obeid PJ, Yammine P, El-Nakat H, et al. Chembiochem : A European Journal of Chemical Biology. 2024;25(23):e202400580. doi:10.1002/cbic.202400580.
- Integrated Technologies for Continuous Monitoring of Organs-on-Chips: Current Challenges and Potential Solutions. Sabaté Del Río J, Ro J, Yoon H, Park TE, Cho YK. Biosensors & Bioelectronics. 2023;224:115057. doi:10.1016/j.bios.2022.115057.
- Organs-on-a-Chip: A Union of Tissue Engineering and Microfabrication. Zhao Y, Wang EY, Lai FBL, Cheung K, Radisic M. Trends in Biotechnology. 2023;41(3):410-424. doi:10.1016/j.tibtech.2022.12.018.