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How Epigenetics and AI Are Transforming Cancer Care

MD Newsline

Release Date: 03/16/2025

Beyond the Delivery Room: Data, Doulas, and Patient-Centered OB-GYN show art Beyond the Delivery Room: Data, Doulas, and Patient-Centered OB-GYN

MD Newsline

In this episode of MD Newsline, Dr. Dillon Bannis, an OB-GYN practitioner based in the South Side of Chicago, shares his insights on the evolving challenges and innovations in obstetric and gynecological care. Dr. Bannis explores how listening, collaboration, and technology are reshaping the patient experience—from prenatal care and delivery practices to addressing health disparities and integrating AI into medicine.

With a strong emphasis on patient-centered communication, interdisciplinary col

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Infant Feeding, Early Habits & Childhood Obesity: What Parents Need to Know show art Infant Feeding, Early Habits & Childhood Obesity: What Parents Need to Know

MD Newsline

In this episode of MD Newsline, Dr. Wanda Averhart, a general pediatrician and obesity medicine specialist, explores the complex causes and lifelong impacts of childhood obesity, emphasizing how early feeding practices, maternal health, and social disparities shape children's long-term outcomes.

Dr. Averhart provides a comprehensive look at how environmental, cultural, and biological factors contribute to rising obesity rates among children—especially in underrepresented communities. She discuss

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The Future of Myeloma: Quadruplets, CAR-T & Beyond show art The Future of Myeloma: Quadruplets, CAR-T & Beyond

MD Newsline

In this episode of MD Newsline, Dr. Shaina A. Rozell, a hematologist-oncologist at Affiliate Oncology in Chicago, Illinois, explores the rapidly advancing field of multiple myeloma treatment. She discusses how quadruplet therapies, MRD monitoring, and novel immunotherapies like bispecific antibodies and CAR-T are transforming outcomes for patients. Dr. Rozell also examines disparities in access to care, the growing role of community practices in clinical trials, and the balance between extending survival

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HPV Throat Cancer Misdiagnoses And How Technology Shapes ENT Health show art HPV Throat Cancer Misdiagnoses And How Technology Shapes ENT Health

MD Newsline

In this episode of MD Newsline, Dr. Tonia L. Farmer, a board-certified otolaryngologist and head & neck surgeon, discusses the gaps in ENT care, the growing impact of HPV-related cancers, and the importance of education and early detection in improving outcomes—particularly for underserved communities. Drawing from years of practice, Dr. Farmer explores how social, behavioral, and environmental factors shape ENT health and shares insights on emerging research and technologies revolutionizing the field.

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Personalized Approaches to Metabolic Liver Disease and MASH Management show art Personalized Approaches to Metabolic Liver Disease and MASH Management

MD Newsline

In this episode of MD Newsline, Dr. Christopher Kaisa, Assistant Professor of Medicine in the Section of Gastroenterology, Hepatology, and Nutrition at the University of Chicago Medicine, provides an in-depth discussion on Metabolic Dysfunction-Associated Steatohepatitis (MASH) and the evolving strategies for its management. He explains the latest non-invasive diagnostic tools, pharmacologic advancements, and the importance of multidisciplinary care in improving outcomes for patients with metabolic liver

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What's Next in Diabetes Care: New Treatments and Tech Insights show art What's Next in Diabetes Care: New Treatments and Tech Insights

MD Newsline

In this episode of MD Newsline, Dr. Rachael Sood, a diabetes nurse practitioner and certified diabetes care and education specialist from New Orleans, Louisiana, shares her insights from the 85th American Diabetes Association Scientific Sessions. As the founder of The Diabetes Collective, Dr. Sood discusses the evolution of diabetology—a specialized field focused solely on the identification, treatment, and management of diabetes across all patient populations.

info_outline High-Risk Multiple Myeloma & Personalized Treatment show art High-Risk Multiple Myeloma & Personalized Treatment

MD Newsline

In this episode of MD Newsline, Dr. Martin Kaiser, Consultant Hematologist at the Royal Marsden Hospital and Professor of Hematology at the Institute of Cancer Research, London, discusses groundbreaking advances in the diagnosis and management of high-risk multiple myeloma. Drawing insights from the OptiMUM trial and related studies, Dr. Kaiser explores how genetic profiling, long-term treatment intensity, and personalized approaches are transforming patient outcomes. He also examines the challenges of t

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Clinical Trials vs Real World Practice in Leukemia Treatment show art Clinical Trials vs Real World Practice in Leukemia Treatment

MD Newsline

In this episode of MD Newsline, Dr. Mark R. Litzow, Professor of Medicine at the Mayo Clinic in Rochester, Minnesota, discusses the groundbreaking findings from the ECOG-ACRIN E1910 trial and the evolving role of immunotherapy in acute lymphoblastic leukemia (ALL). He explores how real-world evidence complements clinical trials, the challenges of standardizing measurable residual disease (MRD) testing, and the future of personalized treatment strategies in hematologic malignancies.

Dr. Litzow shares deep

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MD Newsline

In this episode of MD Newsline, Dr. Sassan Mirfakhraee, adult endocrinologist and associate professor at the University of Texas Southwestern Medical Center, shares groundbreaking insights into the management of adrenal insufficiency. At the Endocrine 2025 conference, Dr. Mirfakhraee presented his research on utilizing insulin pumps to deliver hydrocortisone—an innovative off-label approach that is showing promising results for patients who remain symptomatic on oral therapy.

He explains how thi

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Fighting Bone Metastasis in Breast Cancer show art Fighting Bone Metastasis in Breast Cancer

MD Newsline

In this episode of MD Newsline, we welcome Dr. Emily Zboril, a PhD candidate at Virginia Commonwealth University, to discuss her groundbreaking research on ER-positive breast cancer with bone metastasis. Emily sheds light on the unique challenges of treating this condition, the role of the bone microenvironment, and how novel therapies like lazophoxifene may change the landscape of care.

She explains how endocrine therapies currently used to block estrogen signaling often worsen bone fragility, leading t

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In this episode of MD Newsline, Dr. Diego Marzese, a breast cancer researcher specializing in epigenetics, explores how gene expression changes impact tumor behavior, treatment response, and disease progression. He discusses groundbreaking findings on how tumors activate or deactivate genetic alterations at different stages, the role of ethnicity in epigenetic variations, and how AI and machine learning are accelerating cancer research. Dr. Marzese also highlights the shift toward population-based health recommendations and the future of truly personalized cancer treatment.

Episode Highlights:

The Role of Epigenetics in Breast Cancer

Epigenetics refers to how environmental and lifestyle factors influence gene expression without altering DNA sequences. Dr. Marzese's research focuses on how tumors evolve over time, particularly in triple-negative breast cancer and ductal carcinoma in situ (DCIS). By identifying key epigenetic markers, researchers can predict which pre-cancerous conditions may progress to invasive cancer, enabling earlier and more precise treatment strategies.

Ethnicity and Tumor Behavior

Dr. Marzese's recent study found significant epigenetic differences across ethnic groups, particularly in young African American women with breast cancer. These patients exhibited unique hormone-related and muscle development pathway alterations, which may explain their poorer treatment response and higher disease aggressiveness. These findings emphasize the need for ethnicity-specific health recommendations and a more tailored approach to cancer prevention and treatment.

AI and the Future of Personalized Medicine

With the rise of AI and big data analysis, oncology research is progressing faster than ever. Scientists can now rapidly analyze entire genomes, identifying patient-specific treatment strategies that were once impossible. Dr. Marzese envisions a future where cancer treatment is no longer based on broad subtypes but tailored to each patient's unique genetic and epigenetic profile. However, he stresses that education for healthcare providers is crucial to integrating these advances into clinical practice. Key Takeaway Epigenetics is reshaping breast cancer treatment by revealing how tumors evolve and respond to therapy. AI and personalized medicine are paving the way for patient-specific, ethnicity-informed treatment strategies.

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