Menin Inhibition Shows Potential for Precision Therapy in AML with Dr. Mollie Leoni Kura Oncology
Release Date: 06/25/2024
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Empowered Patient Podcast
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Virtual Support Groups Remove Barriers Encourage Sharing Honest Experiences to Fight Misinformation with Rick Davis AnCan
Empowered Patient Podcast
Rick Davis, patient advocate and Founder of AnCan, is building and operating virtual peer-to-peer support groups to allow patients to connect with others who have direct experience with their condition. These groups can provide accurate information, foster connections among participants, and serve as a check on medical misinformation. With the growing acceptance of virtual meetings, this approach overcomes geographic, physical, and psychosocial barriers that might otherwise prevent participants from attending on-site meetings. Rick explains, "The mission is to make each person and each...
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Empowered Patient Podcast
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Healthcare Plans Using Analytics to Improve Health Literacy Patient Engagement and Outcomes with Bob Farrell mPulse
Empowered Patient Podcast
Bob Farrell, CEO of mPulse, is using digital technology, data analytics and AI to improve the relationship between health plans and their members in order to improve health outcomes and operational efficiency. Bob introduces the concept of HXI, Health Experience and Insights, as a framework that unites data, intelligence, and personalized communication to provide tools to enage members at the best time and by the preferred methods with appropriate information at the right time. Analyzing claims data enables plans to identify high-risk patients, promote preventive care, and build health...
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AI-Powered Drug Discovery Platform Transforms Broad Antiviral Development with Rick Pierce Decoy Therapeutics TRANSCRIPT
Empowered Patient Podcast
Rick Pierce, Co-Founder and CEO of Decoy Therapeutics. is using AI and machine learning to accelerate drug discovery and is developing broad-acting antivirals using peptide conjugates that target a shared invasion mechanism of hundreds of viruses. The company is using small language models and a high-speed peptide synthesizer to dramatically reduce drug creation time. Rick predicts that the future of drug discovery will combine AI-driven design with advanced biological models, such as organoids, to better predict drug toxicity and efficacy. Rick explains, "Decoy Therapeutics was founded...
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AI-Powered Drug Discovery Platform Transforms Broad Antiviral Development with Rick Pierce Decoy Therapeutics
Empowered Patient Podcast
Rick Pierce, Co-Founder and CEO of Decoy Therapeutics. is using AI and machine learning to accelerate drug discovery and is developing broad-acting antivirals using peptide conjugates that target a shared invasion mechanism of hundreds of viruses. The company is using small language models and a high-speed peptide synthesizer to dramatically reduce drug creation time. Rick predicts that the future of drug discovery will combine AI-driven design with advanced biological models, such as organoids, to better predict drug toxicity and efficacy. Rick explains, "Decoy Therapeutics was founded...
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Concierge Healthcare Services for Employees of Self-Insured Companies with Dr. Kumar Dharmarajan World Class Health TRANSCRIPT
Empowered Patient Podcast
Dr. Kumar Dharmarajan, cardiologist and geriatrician and Co-Founder and Chief Medical Officer at World Class Health, is bringing concierge healthcare to employees of self-insured companies. The platform includes a global network of top-tier doctors and nurse navigators. Directly negotiating with providers reduces costs and reduces administrative and financial friction for patients seeking planned procedures. The model also reduces friction for physicians by providing them with complete patient records and ensuring prompt payment. Kumar explains, "We are a global,...
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Concierge Healthcare Services for Employees of Self-Insured Companies with Dr. Kumar Dharmarajan World Class Health
Empowered Patient Podcast
Dr. Kumar Dharmarajan, cardiologist and geriatrician and Co-Founder and Chief Medical Officer at World Class Health, is bringing concierge healthcare to employees of self-insured companies. The platform includes a global network of top-tier doctors and nurse navigators. Directly negotiating with providers reduces costs and reduces administrative and financial friction for patients seeking planned procedures. The model also reduces friction for physicians by providing them with complete patient records and ensuring prompt payment. Kumar explains, "We are a global,...
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Direct-to-Consumer Health Tools and AI Making Medical Information Accessible with Brent Dial Beek Health TRANSCRIPT
Empowered Patient Podcast
Brent Dial, Founder and CEO of Beek Health, has built a platform that addresses patient information fragmentation by aggregating data from patient portals and providing direct access to lab testing. Health literacy is key to preventing chronic diseases, and AI is being used to scale the delivery of personalized health information. Identifying relevant biomarkers and early warning signs supports proactive health management that can alter long-term health outcomes. Brent explains, "Beek Health is re-imagining healthcare by finally putting the individual at the center of their health journey....
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Direct-to-Consumer Health Tools and AI Making Medical Information Accessible with Brent Dial Beek Health
Empowered Patient Podcast
Brent Dial, Founder and CEO of Beek Health, has built a platform that addresses patient information fragmentation by aggregating data from patient portals and providing direct access to lab testing. Health literacy is key to preventing chronic diseases, and AI is being used to scale the delivery of personalized health information. Identifying relevant biomarkers and early warning signs supports proactive health management that can alter long-term health outcomes. Brent explains, "Beek Health is re-imagining healthcare by finally putting the individual at the center of their health journey....
info_outlineDr. Mollie Leoni, Executive Vice President for Clinical Development of Kura Oncology, discusses the company's ziftomenib program, a menin inhibitor for acute myeloid leukemia (AML). The company initially allowed all AML patients to participate in the clinical study, but later found that specific subtypes, such as those with NPM1 mutation or KMT2A rearrangement, were more likely to respond to the menin inhibitor. They also discovered other subtypes that were responsive, expanding the potential patient population. Understanding the role of menin and menin inhibitors in addressing abnormal gene expression and promoting healthy cell development opens the door to potential combination therapy, where menin inhibitors could be layered onto existing treatments for various cancers related to menin independence.
Mollie explains, "In oncology, we have gotten good at treating the end state, but cancer has many, many causes with a common final endpoint to the way the cells look. So, it's many, many different diseases all at once. We've learned and are learning that with better technology and a better understanding of cancer in general we can identify not just how to stop the end state but how to stop it from starting."
"That's where ziftomenib comes in. Ziftomenib addresses key mutations that when they occur, are what cause the development of cancer. So you're able to shut down the development and force the cells to develop normally rather than waiting until they're already diseased and killing them with chemotherapy or some other cytotoxic agent."
"There is a protein complex that we refer to as the menin MLL complex, which goes rogue when something unusual happens in the cell. For example, that could be an NPM1 mutation. That could be a KMT2A rearrangement. Those are two things that are well-known to happen within AML diseases. It could also be a SETD2 RUNX1 mutation. So many types of mutations could happen that could cause this machinery to go rogue within the cell. And that complex causes genes to become active at levels and at times that are abnormal."
#KuraOncology #Ziftomenib #MeninInhibitors #PrecisionMedicine #BTD #AML
