Menin Inhibition Shows Potential for Precision Therapy in AML with Dr. Mollie Leoni Kura Oncology
Release Date: 06/25/2024
Proactive Care and Digital Tools Are Transforming Senior Living Facilities with Kristy Yoskey PointClickCare TRANSCRIPT
Empowered Patient Podcast
Kristy Yoskey, VP and Market Leader at PointClickCare, sees the evolution of demands of those living in senior living facilities from expecting basic housing to a desire for lifestyle choices, health services, and engagement in meaningful activities. On the facilities side, there is a shift from reactive to proactive care, where technology is used to monitor residents, identify behavioral changes, support clinical decision-making, and intervene early to prevent adverse events. In addition, the complexity of resident care is increasing, blurring the line between hospitality and healthcare and...
info_outline
Proactive Care and Digital Tools Are Transforming Senior Living Facilities with Kristy Yoskey PointClickCare
Empowered Patient Podcast
Kristy Yoskey, VP and Market Leader at PointClickCare, sees the evolution of demands of those living in senior living facilities from expecting basic housing to a desire for lifestyle choices, health services, and engagement in meaningful activities. On the facilities side, there is a shift from reactive to proactive care, where technology is used to monitor residents, identify behavioral changes, support clinical decision-making, and intervene early to prevent adverse events. In addition, the complexity of resident care is increasing, blurring the line between hospitality and healthcare and...
info_outline
Using Behavioral Science to Expand Clinical Trial Participation and Patient Engagement with Sarah Smith Oracle Life Sciences TRANSCRIPT
Empowered Patient Podcast
Sarah Smith, Qualitative Specialist and Global Behavioral Science Strategy Lead at Oracle Life Sciences, is focused on the critical role of behavioral science in improving recruitment and retention in clinical trials. Oracle Life Sciences is working to address historical underrepresentation in clinical trials by combining behavioral insights with integrated technologies to identify at-risk populations and understand barriers to participation. Using nudges to encourage trial participation, conducting decentralized trials, and applying AI to reshape patient engagement are strong tools for...
info_outline
Using Behavioral Science to Expand Clinical Trial Participation and Patient Engagement with Sarah Smith Oracle Life Sciences
Empowered Patient Podcast
Sarah Smith, Qualitative Specialist and Global Behavioral Science Strategy Lead at Oracle Life Sciences, is focused on the critical role of behavioral science in improving recruitment and retention in clinical trials. Oracle Life Sciences is working to address historical underrepresentation in clinical trials by combining behavioral insights with integrated technologies to identify at-risk populations and understand barriers to participation. Using nudges to encourage trial participation, conducting decentralized trials, and applying AI to reshape patient engagement are strong tools for...
info_outline
Using Deep Brain Stimulation for Treatment-Resistant Depression with Dr. Josh Eloge Connected Neuroscience TRANSCRIPT
Empowered Patient Podcast
Dr. Josh Eloge, Associate Director for the Woman's Board Treatment Research Center, Assistant Professor of Psychiatry and Behavioral Sciences at the Rush University Medical Center, and Founder of Connected Neuroscience has a focus on treatment-resistant depression which is defined as depression that is not relieved by at least two first-line medications. Research has identified that TRD is associated with hyperactivity in a specific brain region, shifting attention from a chemical view of depression to a neurobiological one. Research on deep-brain stimulation and implantable technology...
info_outline
Using Deep Brain Stimulation for Treatment-Resistant Depression with Dr. Josh Eloge Connected Neuroscience
Empowered Patient Podcast
Dr. Josh Eloge, Associate Director for the Woman's Board Treatment Research Center, Assistant Professor of Psychiatry and Behavioral Sciences at the Rush University Medical Center, and Founder of Connected Neuroscience has a focus on treatment-resistant depression which is defined as depression that is not relieved by at least two first-line medications. Research has identified that TRD is associated with hyperactivity in a specific brain region, shifting attention from a chemical view of depression to a neurobiological one. Research on deep-brain stimulation and implantable technology...
info_outline
Addressing Health Disparities Through Workforce Diversity and Improved Access to Clinical Trials with Dr. Eugene Manley STEMM & Cancer Health Equity Foundation TRANSCRIPT
Empowered Patient Podcast
Dr. Eugene Manley, biomedical scientist turned social impact leader and Founder and CEO of the STEMM & Cancer Health Equity Foundation, is focused on increasing STEMM workforce diversity and improving outcomes for underserved cancer patients. He highlights the lack of diversity in foundational lung cancer research and the need to expand the number of cell lines being included to develop more effective therapies. Eugene also raises concerns about barriers to clinical trial participation and the need to engage local community partners and AI to raise awareness and improve...
info_outline
Addressing Health Disparities Through Workforce Diversity and Improved Access to Clinical Trials with Dr. Eugene Manley STEMM & Cancer Health Equity Foundation
Empowered Patient Podcast
Dr. Eugene Manley, biomedical scientist turned social impact leader and Founder and CEO of the STEMM & Cancer Health Equity Foundation, is focused on increasing STEMM workforce diversity and improving outcomes for underserved cancer patients. He highlights the lack of diversity in foundational lung cancer research and the need to expand the number of cell lines being included to develop more effective therapies. Eugene also raises concerns about barriers to clinical trial participation and the need to engage local community partners and AI to raise awareness and improve...
info_outline
How Community-Based Clinical Trials Can Transform Patient Access and Participation with Ro Wickramasinghe Pi Health TRANSCRIPT
Empowered Patient Podcast
Ro Wickramasinghe, Vice President and Head of Global Business at Pi Health, identifies fundamental problems plaguing clinical trials, including operational inefficiencies and limited access to trials. Pi Health is addressing these challenges by developing an integrated software platform for clinical trial sponsors, sites, and patients and partnering with community-based cancer treatment centers worldwide. The company has built a hospital in India to serve as a living laboratory to test and refine its model to democratize access and increase the ethnic diversity of trial...
info_outline
How Community-Based Clinical Trials Can Transform Patient Access and Participation with Ro Wickramasinghe Pi Health
Empowered Patient Podcast
Ro Wickramasinghe, Vice President and Head of Global Business at Pi Health, identifies fundamental problems plaguing clinical trials, including operational inefficiencies and limited access to trials. Pi Health is addressing these challenges by developing an integrated software platform for clinical trial sponsors, sites, and patients and partnering with community-based cancer treatment centers worldwide. The company has built a hospital in India to serve as a living laboratory to test and refine its model to democratize access and increase the ethnic diversity of trial...
info_outlineDr. Mollie Leoni, Executive Vice President for Clinical Development of Kura Oncology, discusses the company's ziftomenib program, a menin inhibitor for acute myeloid leukemia (AML). The company initially allowed all AML patients to participate in the clinical study, but later found that specific subtypes, such as those with NPM1 mutation or KMT2A rearrangement, were more likely to respond to the menin inhibitor. They also discovered other subtypes that were responsive, expanding the potential patient population. Understanding the role of menin and menin inhibitors in addressing abnormal gene expression and promoting healthy cell development opens the door to potential combination therapy, where menin inhibitors could be layered onto existing treatments for various cancers related to menin independence.
Mollie explains, "In oncology, we have gotten good at treating the end state, but cancer has many, many causes with a common final endpoint to the way the cells look. So, it's many, many different diseases all at once. We've learned and are learning that with better technology and a better understanding of cancer in general we can identify not just how to stop the end state but how to stop it from starting."
"That's where ziftomenib comes in. Ziftomenib addresses key mutations that when they occur, are what cause the development of cancer. So you're able to shut down the development and force the cells to develop normally rather than waiting until they're already diseased and killing them with chemotherapy or some other cytotoxic agent."
"There is a protein complex that we refer to as the menin MLL complex, which goes rogue when something unusual happens in the cell. For example, that could be an NPM1 mutation. That could be a KMT2A rearrangement. Those are two things that are well-known to happen within AML diseases. It could also be a SETD2 RUNX1 mutation. So many types of mutations could happen that could cause this machinery to go rogue within the cell. And that complex causes genes to become active at levels and at times that are abnormal."
#KuraOncology #Ziftomenib #MeninInhibitors #PrecisionMedicine #BTD #AML
