Treating Septic Shock with Nanoparticle Formulation that Redistributes Nitric Oxide with Dr. Harven DeShield Vivacelle Bio TRANSCRIPT
Release Date: 09/23/2024
Empowered Patient Podcast
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Matt Brown, VP of Telehealth at Advisory Services at CHG Healthcare, discusses the current state and future of telehealth, including the rapid adoption during the COVID-19 pandemic, the role of technology and AI in enhancing telehealth experiences, and how telehealth can help address physician and nurse burnout. Improved internet access, mobile device usage, and consumer preferences for convenience have driven the increasing telehealth usage for initial visits, follow-up appointments, and chronic care management. Matt explains, "We are the nation's largest staffing agency. So, we're...
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Dr. Chuck Link is the Executive Chairman of Syncromune, a company developing a novel immunotherapy approach for solid tumors by delivering the therapy into the tumor and surrounding lymph nodes to stimulate a systemic immune response. Their complex drug has four different components with varying levels of activity that activate the immune system and counteract immune suppression. This in situ immunotherapy technology, SYNC-T, was tested in a phase 1 trial for metastatic castration-resistant prostate cancer, which showed high response rates and a favorable safety profile with low rates of...
info_outlineDr. Harven DeShield is the CEO and Co-Founder of Vivacelle Bio, which is developing a nanoparticle-based treatment called VBI-S to address the underlying causes of septic shock. The treatment works by efficiently redistributing nitric oxide to help regulate blood pressure and improve organ function, reducing the need for traditional vasopressor treatments. Vivacelle is also developing a product to help address hemorrhagic shock and minimize reperfusion injury.
Harven explains, "There are seven aspects to septic shock - actually eight. So, first, you have an infection. You have to have an infection, whether it is a bacterial, virus, or fungus. And then, eventually, they give you fluids—your blood pressure drops. And so, they try to correct that by giving you fluids. And when the fluids fail, then you transition from sepsis to septic shock."
"Then, you are also dealing with the fact that they put you on vasopressors once you get into septic shock. When they put you on vasopressors, that creates another whole realm of problems, which I can get into later. But, essentially, they have some serious toxicity effects, including reducing cardiac output. It causes cardiac arrhythmia and blood clots and can even lead somebody to go into hemorrhagic shock. So, you have the infection problems, you have the relative and absolute hypovolemia problem."
"Our product, for example, works within, and I’m using phase 2a - we see results in as little as 90 minutes, in terms of, at least, correcting the blood pressure. And it really can be very severe, and time is of the essence. There used to be something they called the "golden hour”. This means you have an hour, depending on how low your blood pressure is. Now, some people call it the "platinum ten minutes".
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